Now showing items 1-11 of 11

    • Paula Lima, Andrea; Adasme, Tatiana; San Martín Rovirosa, Carol; Sebollela, Adriano; Hetz Flores, Claudio; Carrasco Friz, María Angélica; Ferreira, Sergio T.; Hidalgo Tapia, María Cecilia (MARY ANN LIEBERT INC, 2011-04)
      Soluble amyloid beta-peptide oligomers (A beta Os), increasingly recognized as causative agents of Alzheimer's disease (AD), disrupt neuronal Ca(2+) homeostasis and synaptic function. Here, we report that A beta Os at ...
    • Paula Lima, Andrea; Adasme, Tatiana; San Martín Rovirosa, Carol; Sebollela, Adriano; Hetz Flores, Claudio; Carrasco, M. Angélica; Ferreira, Sergio T.; Hidalgo Tapia, María Cecilia (2011)
      Soluble amyloid β-peptide oligomers (AβOs), increasingly recognized as causative agents of Alzheimer's disease (AD), disrupt neuronal Ca2+ homeostasis and synaptic function. Here, we report that AβOs at sublethal concentrations ...
    • San Martín Barrientos, Aurelio; Rovirosa, Juana; Astudillo, Luis; Sepúlveda, Beatriz; Ruiz, Daniela; San Martín Rovirosa, Carol (TAYLOR & FRANCIS LTD, 2008-01-09)
      Continued investigation of the marine alga Laurencia claviformis has led to the isolation of pacifenol, a halogenated sesquiterpene as the major metabolite. The microbial transformation of pacifenol is reported. It was ...
    • San Martín Rovirosa, Carol; Garri, Carolina; Pizarro Aguirre, Fernando; Walter, Tomas; Theil, Elizabeth C.; Núñez González, Marco (2008)
      Iron deficiency, a condition currently affecting similar to 3 billion people, persists in the 21st century despite half a millennium of medical treatment. Soybean ferritin (SBFn), a large, stable protein nanocage around a ...
    • San Martín Rovirosa, Carol; Garri, Carolina; Pizarro Aguirre, Fernando; Walter, Tomas; Theil, Elizabeth C.; Núñez González, Marco (Journal of Nutrition, 2008-05)
      Iron deficiency, a condition currently affecting ;3 billion people, persists in the 21st century despite half a millennium of medical treatment. Soybean ferritin (SBFn), a large, stable protein nanocage around a mineral ...
    • Cuesta Astroz, Yesid; Gischkow Rucatti, Guilherme; Murgas, Leandro; San Martín Rovirosa, Carol; Sanhueza, Mario; Martin, Alberto J. M. (Frontiers Media, 2021)
      Gene Regulatory Networks (GRNs) allow the study of regulation of gene expression of whole genomes. Among the most relevant advantages of using networks to depict this key process, there is the visual representation of large ...
    • Ponce, Daniela P.; Salech Morales, Felipe; San Martín Rovirosa, Carol; Silva, Monica; Xiong, Chengjie; Roe, Catherine M.; Henríquez, Mauricio; Quest, Andrew F. G.; Behrens Pellegrino, María Isabel (Bentham Science Publishers B.V., 2014)
      © 2014 Bentham Science Publishers.We previously reported on enhanced susceptibility to death of lymphocytes from Alzheimer’s disease (AD) patients when exposed to hydrogen peroxide (H2O2)-induced oxidative stress and an ...
    • San Martín Rovirosa, Carol; Paula Lima, Andrea; García, Alejandra; Barattini, Pablo; Hartel, Steffen; Núñez González, Marco; Hidalgo Tapia, María Cecilia (Gaiti Hasan,Tata Institute of Fundamental Research, 2014)
      Mountingevidenceindicatesthatironaccumulationimpairsbrainfunction.Wehavereportedpreviouslythatadditionofsub-lethalconcentrationsofirontoprimaryhippocampalneuronsproducesCa2+signalsandpromotescytoplasmicgenerationofreacti ...
    • San Martín Rovirosa, Carol; Paula Lima, Andrea; García, Alejandra; Barattini, Pablo; Hartel, Steffen; Núñez González, Marco; Hidalgo Tapia, María Cecilia (2014)
      Mounting evidence indicates that iron accumulation impairs brain function. We have reported previously that addition of sub-lethal concentrations of iron to primary hippocampal neurons produces Ca2+ signals and promotes ...
    • San Martín Rovirosa, Carol; Veloso, Pablo; Adasme, Tatiana; Lobos, Pedro; Bruna, Barbara; Galaz, Jose; García, Alejandra; Hartel, Steffen; Hidalgo Tapia, María Cecilia; Paula Lima, Andrea (Frontiers Research Foundation, 2017)
      © 2017 SanMartín, Veloso, Adasme, Lobos, Bruna, Galaz, García, Hartel, Hidalgo and Paula-Lima. Amyloid β peptide oligomers (AβOs), toxic aggregates with pivotal roles in Alzheimer’s disease, trigger persistent and low ...
    • San Martín Rovirosa, Carol; Paula Lima, Andrea; Hidalgo Tapia, María Cecilia; Núñez González, Marco (2012)
      Two major lesions are pathological hallmarks in Alzheimer's disease (AD): the presence of neurofibrillary tangles formed by intracellular aggregates of the hyperphosphorylated form of the cytoskeletal tau protein, and of ...