Now showing items 1-16 of 16

    • Salgado, Francisco; Areche, Carlos; Sepúlveda, Beatriz; Simirgiotis, Mario J.; Cáceres, Fátima; Quispe, Cristina; Quispe, Lina; Cano, Teresa (Medknow Publications, 2014)
      Background: Azorella compacta is a rare yellow-green compact resinous cushion shrub growing from the high Andes of southern Peru to northwestern Argentina, and which is a producer of biologically active and unique diterpenoids. ...
    • Brito, Anghel; Areche, Carlos; Sepúlveda, Beatriz; Kennelly, Edward J.; Simirgiotis, Mario J. (MDPI AG, 2014)
      The anthocyanin composition and HPLC fingerprints of six small berries endemic of the VIII region of Chile were investigated using high resolution mass analysis for the first time (HR-ToF-ESI-MS). The antioxidant features ...
    • Quesada, Luisa; Areche Medina, Carlos; Astudillo, Luis; Gutiérrez, Margarita; Sepúlveda, Beatriz; San Martín Barrientos, Aurelio (Natural Products, 2012)
      Four isoflavones, isolated from the whole plant of Azorella madreporica, were identified as angustone C (1), alpinumisoflavone (2), licoisoflavone A (3) and isolupalbigenin (4) by spectroscopic studies. The compounds were ...
    • San Martín Barrientos, Aurelio; Rovirosa, Juana; Astudillo, Luis; Sepúlveda, Beatriz; Ruiz, Daniela; San Martín Rovirosa, Carol (TAYLOR & FRANCIS LTD, 2008-01-09)
      Continued investigation of the marine alga Laurencia claviformis has led to the isolation of pacifenol, a halogenated sesquiterpene as the major metabolite. The microbial transformation of pacifenol is reported. It was ...
    • Simirgiotis, Mario J.; Vallejos, Javier; Areche, Carlos; Sepúlveda, Beatriz (MDPI AG, 2014)
      © 2014 by the authors; licensee MDPI, Basel, Switzerland. An enantioselective total synthesis of the natural amino acid (2S,4R,5R)-4,5-dihydroxy-pipecolic acid starting from D-glucoheptono-1, 4-lactone is presented. The ...
    • Simirgiotis, Mario J.; Quispe, Cristina; Borquez, Jorge; Areche Medina, Carlos; Sepúlveda, Beatriz (MDPI AG, POSTFACH, CH-4005 BASEL, SWITZERLAND, 2016)
      A small Chilean variety of pears growing in the town of Toconao, an oasis located at the northeastern edge of the Salar de Atacama, northern Chile, was studied by means of modern PDA and high resolution mass spectral data ...
    • Areche Medina, Carlos; Rojas-Álvarez, Francisca; Campos-Briones, Carolina; Lima, Carlos; Pérez, Edwin G.; Sepúlveda, Beatriz (Royal Pharmaceutical Society, 2013-04-11)
      The chemical study of a dichloromethane extract from Azorella compacta was directed to the isolation of characteristic mulinane and azorellane diterpenoids in order to determine their gastroprotective activity. Methods ...
    • Parra, Teresa; Benites, Julio; Ruiz, Lina M.; Sepúlveda, Beatriz; Simirgiotis, Mario; Areche Medina, Carlos (Elsevier, 2015)
      Seventeen compounds (2-18) synthetized from the diterpenoid ent-beyer-15-en-18-ol (1) isolated from aerial part of Baccharis tola were tested for their gastroprotective activity on the model of HCl/EtOH-induced gastric ...
    • Areche, Carlos; San Martín Barrientos, Aurelio; Rovirosa, Juana; Sepúlveda, Beatriz (2011)
      The effects of epitaondiol (1) and sargaol (2), isolated from the brown alga Stypopodium flabelliforme on HCl/ethanol-induced gastric lesions in mice were evaluated and compared with that of lansoprazole. Epitaondiol and ...
    • Ardiles, Alejandro; Barrientos, Ruth; Simirgiotis, Mario J.; Bórquez, Jorge; Sepúlveda, Beatriz; Areche, Carlos (MDPI AG, 2018)
      © 2018 MDPI AG. All rights reserved. Forty-three metabolites including several methoxylated flavonoids, tremetones, and ent-clerodane diterpenes were accurately identified for the first time in the ethanolic extract of P. ...
    • Sepúlveda, Beatriz; Quispe, Cristina; Simirgiotis, Mario; García Beltrán, Olimpo; Areche Medina, Carlos (Elsevier, 2016)
      Mulinane diterpenoids isolated from Azorella species have displayed gastroprotective effects in animal models. In this study we have transformed the main constituent, mulin-11,13-dien-20 oic acid from this plant using the ...
    • Brito, Anghel; Ramirez, Javier E.; Areche, Carlos; Sepúlveda, Beatriz; Simirgiotis, Mario J. (MDPI AG, 2014)
      © 2014 by the authors; licensee MDPI.Peels and edible pulp from three species of citrus including Citrus aurantifolia (varieties pica and sutil) and Citrus x lemon var. Genova widely cultivated and consumed in Northern ...
    • Torres-Benítez, Alfredo; Rivera-Montalvo, Mariá; Sepúlveda, Beatriz; Castro, Olivio N.; Nagles, Edgar; Simirgiotis, Mario J.; Garciá-Beltrán, Olimpo; Areche, Carlos (MDPI AG, 2017)
      © 2017 by the authors. Lichens are symbiotic associations of fungi with microalgae and/or cyanobacteria. Lichens belonging to the Parmeliaceae family comprise 2700 species of lichens, including the Parmotrema genus which ...
    • Areche Medina, Carlos; Benites, Julio; Cornejo, Alberto; Ruiz, Lina M.; García Beltrán, Olimpo; Simirgiotis, Mario J.; Sepúlveda, Beatriz (2015)
      Ten known meroterpenoids and the new meroterpenoid 7 were isolated from the Chilean seaweed Stypopodium flabelliforme as their acetylated derivatives. Furthermore, the known metabolite taondiol has been isolated for the ...
    • Simirgiotis, Mario J.; Quispe, Cristina; Mocan, Andrei; Villatoro, José Miguel; Areche, Carlos; Bórquez, Jorge; Sepúlveda, Beatriz; Echiburu-Chau, Carlos (Sociedade Brasileira de Farmacognosia, 2017)
      © 2016 Sociedade Brasileira de Farmacognosia. High-resolution mass spectrometry is currently used to determine the mass of biologically active compounds in plants and UHPLC-Orbitrap is a relatively new technology that ...
    • Areche Medina, Carlos Alberto; Romero Parra, Javier Hernán; Sepúlveda, Beatriz; García Beltrán, Olimpo; Simirgiotis, Mario J. (MDPI, 2022)
      Himantormia lugubris is a Chilean native small lichen shrub growing in the Antarctica region. In this study, the metabolite fingerprinting and the antioxidant and enzyme inhibitory potential from this species and its four ...