Browsing by Author "Soto Rifo, Ricardo"

Now showing items 1-13 of 13

    • Análisis de la interacción entre el ARN genómico de VIH-1 y proteínas lectoras de N6-metiladenosina (m6A) ... 
      Thadani Acosta, Alvaro (Universidad de Chile, 2018)
      La epitranscriptomica es considerada una nueva rama de las ciencias biológicas que tiene como finalidad comprender la regulación de la expresión génica mediada por modificaciones químicas en el ARN. La N6-metiladenosina o ...
    • DISC1 promotes translation maintenance during sodium arsenite-induced oxidative stress 
      Fuentes Villalobos, Francisco; Farkas, Carlos; Riquelme Barrios, Sebastián; Armijo, Marisol E.; Soto Rifo, Ricardo; Pincheira, Roxana; Castro, Ariel F. (Elsevier B.V., 2019)
      Variation in Disrupted-in-Schizophrenia 1 (DISC1) increases the risk for neurodegenerative diseases, schizophrenia, and other mental disorders. However, the functions of DISC1 associated with the development of these ...
    • Emerging roles of N - 6 - methyladenosine on HIV - 1 RNA metabolism and viral replication 
      Riquelme Barrios, Sebastián; Pereira Montecinos, Camila; Valiente Echeverría, Fernando Andrés; Soto Rifo, Ricardo (Frontiers Media, 2018)
      N-6-methyladenosine (m(6)A) is the most abundant internal modification present in Eukaryotic mRNA. The functions of this chemical modification are mediated by m(6)-Abinding proteins (m(6)A readers) and regulated by ...
    • Epitranscriptomic regulation of HIV-1 full-length RNA packaging 
      Pereira Montecinos, Camila; Toro Ascuy, Daniela; Ananías Sáez, Catarina; Gaete Argel, Aracelly; Rojas Fuentes, Cecilia; Riquelme Barrios, Sebastián; Rojas Araya, Bárbara; García de Gracia, Francisco; Aguilera Cortés, Paulina; Chnaiderman Figueroa, Jonas; Acevedo Acevedo, Mónica; Valiente Echeverría, Fernando; Soto Rifo, Ricardo (Oxford University Press, 2022)
      During retroviral replication, the full-length RNA serves both as mRNA and genomic RNA. However, the mechanisms by which the HIV-1 Gag protein selects the two RNA molecules that will be packaged into nascent virions remain ...
    • Epitranscriptomic regulation of viral replication 
      Pereira-Montecinos, Camila; Valiente-Echeverría, Fernando; Soto Rifo, Ricardo (Elsevier B.V., 2017)
      © 2017 RNA plays central roles in biology and novel functions and regulation mechanisms are constantly emerging. To accomplish some of their functions within the cell, RNA molecules undergo hundreds of chemical modifications ...
    • HIV-2 genomic RNA accumulates in stress granules in the absence of active translation 
      Soto Rifo, Ricardo; Valiente Echeverría, Fernando Andrés; Rubilar, Paulina S.; Garcia-de-Gracia, Francisco; Ricci, Emiliano P.; Limousin, Taran; Décimo, Didier; Mouland, Andrew J.; Ohlmann, Théophile (2014)
      During the post-transcriptional events of the HIV-2 replication cycle, the full-length unspliced genomic RNA (gRNA) is first used as an mRNA to synthesize Gag and Gag-Pol proteins and then packaged into progeny virions. ...
    • Interactions between the HIV-1 unspliced mRNA and host mRNA decay machineries 
      Toro-Ascuy, Daniela; Rojas-Araya, Bárbara; Valiente-Echeverría, Fernando; Soto Rifo, Ricardo (MDPI AG, 2016)
      © 2016 by the authors; licensee MDPI, Basel, Switzerland. The human immunodeficiency virus type-1 (HIV-1) unspliced transcript is used both as mRNA for the synthesis of structural proteins and as the packaged genome. Given ...
    • Rol de la lectora de m6A YTHDC2 en la síntesis de Gag de VIH-1 
      León Díaz, Felipe Ignacio (Universidad de Chile, 2020)
      Una vez integrado en un cromosoma celular, el VIH-1 genera un transcrito único de 9-kb o ARN mensajero completo (ARNmc) que es procesado por corte y empalme para generar los transcritos de 2-kb (completamente procesados) ...
    • Rol de la maquinaria celular de m6A en la replicación y expresión génica del virus respiratorio sincicial humano 
      Figueroa Ahumada, Fabian (2019-04)
      N6-Metiladenosina (m6A) es la modificación química más abundante encontrada en los ARN mensajeros (ARNm) de células eucariontes. Esta modificación regula el metabolismo de los ARNm a diferentes niveles incluidos el corte ...
    • Rol de los componentes del complejo nuclear de unión al cap, CBP80 y CTIF, en la síntesis de la proteína ... 
      García de Gracia, Francisco Javier (Universidad de Chile., 2019-04)
      El virus de la inmunodeficiencia humana de tipo 1 (VIH-1) es un gran problema de salud a nivel mundial. Durante años se ha estudiado su ciclo replicativo con el objeto de generar estrategias que permitan inhibir ...
    • Salmon cells SHK-1 internalize infectious pancreatic necrosis virus by macropinocytosis 
      Levicán-Asenjo, Jorge; Soto Rifo, Ricardo; Aguayo, Francisco; Gaggero Brillouet, Aldo; Leon, Oscar (Blackwell Publishing Ltd, 2019)
      We have previously shown that infectious pancreatic necrosis virus (IPNV) enters the embryo cell line CHSE-214 by macropinocytosis. In this study, we have extended our investigation into SHK-1 cells, a macrophage-like cell ...
    • Seroconversion and abundance of IgG antibodies against S1-RBD of SARS-CoV-2 and neutralizing activity in ... 
      González Stegmaier, R.; Cereceda, K.; Briones, J. L.; Beltrán Pavez, C.; Oyarzún Arrau, A.; Riquelme Barrios, S.; Selman, C.; Yarad, F.; Mahave, M.; Caglevic, C.; Morales, R.; Aguirre, A.; Valiente Echeverría, Fernando Andrés; Soto Rifo, Ricardo; Marsiglia, H.; Gazitúa, R.; Villarroel Espíndola, F. (Hindawi, 2021)
      COVID-19 is a pandemic caused by SARS-CoV-2. In Chile, half a million people have been infected and more than 16,000 have died from COVID-19. As part of the clinical trial NCT04384588, we quantified IgG against S1-RBD of ...
    • Tobacco smoke activates human papillomavirus 16 p97 promoter and cooperates with high-risk E6/E7 for oxidative ... 
      Peña, Nelson; Carrillo, Diego; Muñoz, Juan P.; Chnaiderman, Jonás; Urzúa, Ulises; León, Oscar; Tornesello, Maria L.; Corvalán, Alejandro H.; Soto Rifo, Ricardo; Aguayo, Francisco (Public Library of Science, 2015)
      We have previously shown a functional interaction between human papillomavirus type 16 (HPV-16) E6 and E7 oncoproteins and cigarette smoke condensate (CSC) in lung cells suggesting cooperation during carcinogenesis. The ...