Browsing by Author "Troncoso Cotal, Rodrigo"

Now showing items 1-18 of 18

    • Activity of metalloproteinase-9 is related to oxidative stress in the acute coronary syndrome 
      Bittner, Alex; Castro Agüero, Pablo; Pérez, Osvaldo; Alcaíno Olivares, Hernán Alejandro; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (OXFORD UNIV PRESS, 2006-08)
      Meeting Abstract
    • Atrial Function Assessed by Speckle Tracking Echocardiography Is a Good Predictor of Postoperative Atrial ... 
      Verdejo, Hugo E.; Becerra, Elia; Zalaquett Sepúlveda, Ricardo; Campo, Andrea del; García Nannig, Lorena; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Marín, Arnaldo; Castro, Pablo F.; Lavandero González, Sergio; Gabrielli, Luigi A.; Corbalán, Ramón (Wiley & Sons, 2016)
      ObjectiveAdvanced age is an independent predictor of postoperative atrial fibrillation (POAF) in patients undergoing coronary artery bypass surgery. We evaluated whether left atrial (LA) dysfunction assessed by strain ...
    • Beta(2)-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation 
      Aránguiz Urroz, Pablo Daniel; Canales Urriola, Jimena Andrea; Copaja, Miguel; Troncoso Cotal, Rodrigo; Vicencio Bustamante, José Miguel; Carrillo Ballesteros, Constanza Carolina; Lara Peñaloza, Hernán; Lavandero González, Sergio; Díaz Araya, Guillermo (ELSEVIER SCIENCE BV, 2011-01)
      Autophagy is a physiological degradative process key to cell survival during nutrient deprivation, cell differentiation and development. It plays a major role in the turnover of damaged macromolecules and organelles, and ...
    • Differential Participation of Angiotensin II Type 1 and 2 Receptors in the Regulation of Cardiac Cell Death ... 
      Aránguiz Urroz, Pablo Daniel; Soto Muñoz, Dagoberto; Contreras Ferrat, Ariel Eduardo; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Montenegro Obregón, José Joaquín; Venegas Pino, Daniel Esteban; Smolic Smolic, Christian; Ayala Jeria, Pedro Segundo; Thomas, W. G.; Lavandero González, Sergio; Díaz Araya, Guillermo (NATURE PUBLISHING GROUP, 2009-05)
      The Angiotensin II (Ang II) type 1 (AT(1)R) and type 2 (AT(2)R) receptors are increased in the heart following myocardial infarction and dilated cardiomyopathy, yet their contribution at a cellular level to compensation ...
    • Efectos del carvedilol en la capacidad funcional, función ventricular izquierda, catecolaminas y estrés ... 
      Castro, Pablo; Pérez, Osvaldo; Greig, Douglas; Díaz Araya, Guillermo; Moraga, Francisco; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Padilla, Ivonne; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Lavandero González, Sergio (Sociedad Española de Cardiología, 2004)
      El carvedilol es un antagonista adrenérgico con acción antioxidante y un demostrado beneficio sobre la mortalidad en insuficiencia cardíaca (IC). El objetivo de este estudio es evaluar, en pacientes con insuficiencia ...
    • Effects of carvedilol on functional capacity, left ventricular function, catecholamines and oxidative stress ... 
      Castro Agüero, Pablo; Pérez, Osvaldo; Greig, Douglas; Díaz Araya, Guillermo; Moraga, Francisco; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Padilla, Ivonne; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Lavandero González, Sergio (EDICIONES DOYMA S/L, 2004-11)
      Introduction and objective. Carvedilol is an antioxidant and adrenergic antagonist with demonstrated benefits in terms of mortality from heart failure (HF). The aim of the present study was to evaluate clinical parameters, ...
    • Effects of carvedilol on oxidative stress and chronotropic response to exercise in patients with chronic ... 
      Castro, Pablo; Mc-Nab, Pablo; Quintana, Juan Carlos; Bittner, Alex; Greig, Douglas; Vergara, Ismael; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Copaja, Miguel; Díaz Araya, Guillermo; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Alcaíno Gálvez, Hernán Alejandro; Lavandero González, Sergio (ELSEVIER SCIENCE BV, 2005-10)
      Background: Our previous studies suggest that the increase in heart rate from rest to peak exercise is reduced in patients with chronic heart failure (CHF) and this is associated with increased oxidative stress, as determined ...
    • Effects of Carvedilol upon intra- and interventricular synchrony in patients with chronic heart failure 
      Castro, Pablo; Mac Nab, Paul; Quintana, Juan Pablo; Bittner, Alex; Greig, Douglas; Vergara, I.; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Copaja, Miguel; Díaz Araya, Guillermo; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Alcaíno Olivares, Hernán Alejandro; Lavandero González, Sergio (EXCERPTA MEDICA INC, 2005-07-15)
      Radionuclide isotopic ventriculography with phase analysis was performed in 30 patients with stable heart failure (HF), determining left ventricular (LV) and interventricular contraction synchrony at baseline and after 6 ...
    • FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes 
      Oyarzún, Alejandra P.; Westermeier, Francisco; Pennanen, Christian; López Crisosto, Camila; Parra, Valentina; Sotomayor Flores, Cristian; Sánchez, Gina; Pedrozo Cibils, Zully; Troncoso Cotal, Rodrigo; Lavandero González, Sergio (Elsevier, 2015)
      Aim: FK866 is an inhibitor of the NAD(+) synthesis rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT). Using FK866 to target NAD(+) synthesis has been proposed as a treatment for inflammatory diseases and ...
    • Gln(27)-> Glu beta(2)-Adrenergic Receptor Polymorphism in Heart Failure Patients: Differential Clinical and ... 
      Troncoso Cotal, Rodrigo; Moraga, Francisco; Chiong Lay, Mario; Roldán S., Juan; Bravo Méndez, Roberto; Valenzuela, Rodrigo; Díaz Araya, Guillermo; Campo Sfeir, Andrea Estefanía del; Sanhueza Muñoz, Carlos Joaquín; Rodríguez Villarroel, Andrea Elizabeth; Vukasovic Ramírez, José Luis; Mellado, Rose Marie; Greig, Douglas; Castro, Pablo; Lavandero González, Sergio (WILEY-BLACKWELL PUBLISHING, 2009-05)
      We investigated the clinical response of chronic heart failure patients with beta(2)- adrenergic receptor Gln(27)-> Glu polymorphism treated for 6 months with carvedilol, a alpha/beta-antagonist with antioxidant properties. ...
    • IGF-1: Un factor de crecimiento con acciones cardiovasculares pleiotrópicas. 
      Contreras Ferrat, Ariel Eduardo; Aránguiz Urroz, Pablo Daniel; Díaz Elizondo, Jessica; Chiong Lay, Mario; Muñoz, Juan Pablo; Parra Ortíz, María Valentina; Ibarra, Cristián; Rojas Rivera, Diego; Troncoso Cotal, Rodrigo; Eisner, Verónica; Salas, Daniela; Rodríguez Villarroel, Andrea Elizabeth; Carrasco Alarcón, Loreto del Pilar; Díaz Araya, Guillermo; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2006)
      El factor de crecimiento análogo a insulina tipo 1 (IGF-1) es un péptido relacionado estructural y funcionalmente con insulina que posee efectos mitogénicos y citoprotectores. Sus efectos biológicos dependen de la activación ...
    • Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases ... 
      Bravo Méndez, Roberto; Vicencio Bustamante, José Miguel; Parra Ortíz, María Valentina; Troncoso Cotal, Rodrigo; Muñoz, Juan Pablo; Bui, Michael; Quiroga Lagos, Clara; Rodríguez Villarroel, Andrea Elizabeth; Verdejo, Hugo; Ferreira Parker, Jorge; Iglewski, Miriam; Chiong Lay, Mario; Simmen, Thomas; Zorzano, Antonio; Hill, Joseph A.; Rothermel, B. A.; Szabadkai, G.; Lavandero González, Sergio (COMPANY OF BIOLOGISTS LTD, 2011-07-15)
    • La inducción de la proteína de respuesta a estrés FKBP51 produce desensibilación de la señalización de ... 
      Bustos Barriento, Stacy (Universidad de Chile, 2021)
      Introducción: La enfermedad del hígado graso no alcohólico (NAFLD) es la enfermedad hepática más común, donde la resistencia a la insulina (RI) juega un papel fundamental en su patogénesis. Por otro lado, los glucocorticoides ...
    • Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide 
      Muñoz, Juan Pablo; Chiong Lay, Mario; García Nannig, Lorena; Troncoso Cotal, Rodrigo; Toro, Barbra; Pedrozo Cibils, Zully; Díaz Elizondo, Jessica; Salas, Daniela; Parra Ortíz, María Valentina; Núñez González, Marco; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2010-02-15)
      We investigate here the role of reactive oxygen species and nitric oxide in iron-induced cardiomyocyte hypertrophy or cell death Cultured rat cardiomyocytes incubated with 20 mu M iron (added as FeCl3-Na nitrilotriacetate, ...
    • Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through ... 
      Campo Sfeir, Andrea Estefanía del; Parra Ortíz, María Valentina; Vásquez Trincado, César Alonso; Gutiérrez, Tomás; Morales, Pablo E.; López Crisosto, Camila; Bravo Sagua, Roberto; Navarro Márquez, Mario F.; Verdejo, Hugo E.; Contreras Ferrat, Ariel Eduardo; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Lavandero González, Sergio (American Physiological Society, 2014)
      Insulin is a major regulator of glucose metabolism, stimulating its mitochondrial oxidation in skeletal muscle cells. Mitochondria are dynamic organelles that can undergo structural remodeling in order to cope with these ...
    • Organelle communication: Signaling crossroads between homeostasis and disease 
      Bravo Sagua, Roberto; Torrealba Cárdenas, Natalia Belén; Paredes, Felipe; Morales, Pablo E.; Pennanen Saavedra, Christian; López Crisosto, Camila; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Chiong Lay, Mario; Hill, Joseph A.; Simmend, Thomas; Quest, Andrew F. G.; Lavandero González, Sergio (Elsevier, 2014)
      Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are ...
    • Regulation of cardiomyocyte autophagy by calcium 
      Shaikh, Soni; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Bravo Sagua, Roberto; García Nannig, Lorena; Morselli, Eugenia; Cifuentes, Mariana; Quest, Andrew F. G.; Hill, Joseph A.; Lavandero González, Sergio (Amer Physiological Soc, 2016)
      Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion ...
    • Unsaturated fatty acids induce non-canonical autophagy 
      Niso Santano, Mireia; Malik, Shoaib; Pietrocola, Federico; Bravo San Pedro, José; Mariño, Guillermo; Cianfanelli, Valentina; Ben-Younès, Amena; Troncoso Cotal, Rodrigo; Markaki, Maria; Sica, Valentina; Izzo, Valentina; Chaba, Kariman; Bauvy, Chantal; Dupont, Nicolas; Kepp, Oliver; Rockenfeller, Patrick; Wolinski, Heimo; Madeo, Frank; Lavandero González, Sergio; Codogno, Patrice; Harper, Francis; Pierron, Gérard; Tavernarakis, Nektarios; Cecconi, Francesco; Maiuri, Maria Chiara; Galluzzi, Lorenzo; Kroemer, Guido (Wiley-Blackwell, 2015)
      To obtain mechanistic insights into the cross talk between lipolysis and autophagy, two key metabolic responses to starvation, we screened the autophagy-inducing potential of a panel of fatty acids in human cancer cells. ...