Browsing by Author "Varela Figueroa, Nelson"

Now showing items 1-12 of 12

    • As3MT and GST Polymorphisms Influencing Arsenic Metabolism in Human Exposure to Drinking Groundwater 
      González Martínez, Farith; Sánchez Rodas, Daniel; Varela Figueroa, Nelson; Sandoval, Christopher A.; Quiñones Sepúlveda, Luis; Johnson Restrepo, Boris (MDPI, 2020)
      The urinary arsenic metabolites may vary among individuals and the genetic factors have been reported to explain part of the variation. We assessed the influence of polymorphic variants of Arsenic-3-methyl-transferase and ...
    • Asociación de polimorfismos genéticos en NAT2 con el daño hepático inducido por isoniacida, en pacientes ... 
      Moreno Peñaloza, Paulina Andrea (Universidad de Chile, 2020)
      La tuberculosis es una enfermedad infectocontagiosa producida principalmente por la bacteria Mycobaterium tuberculosis. Actualmente, según la OMS, tiene a un tercio de la población mundial contagiada. En Chile, se estima ...
    • CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer ... 
      Quiñones Sepúlveda, Luis; Lucas, D.; Godoy, J.; Cáceres Lillo, Dante; Berthou, F.; Varela Figueroa, Nelson; Lee, K.; Acevedo, C.; Martínez, L.; Aguilera, A. M.; Gil, Lionel (Elsevier, 2001)
      CYP1A1, CYP2E1 and GSTM1 polymorphisms were evaluated in Chilean healthy controls and lung cancer patients. In the Chilean healthy group, frequencies of CYP1A1 variant alleles for MspI (m2 or CYP1A1*2A) and ile/val (val ...
    • Efecto de angiotensina II sobre los niveles de mRNA de citoquinas y moléculas de adhesión en fibroblastos cardiacos 
      Bruggendieck Caru, Francisca Antonieta (Universidad de Chile, 2019)
      Cuando ocurre un daño tisular o infeccioso en el corazón se inicia un conjunto de respuestas que llevarán a la reparación del tejido dañado. En esta situación, adquiere protagonismo un tipo celular cardiaco llamado fibroblasto ...
    • Ethnic susceptibility to lung cancer: differences in CYP2E1, CYP1A1 and GSTM1 genetic polymorphisms between ... 
      Quiñones Sepúlveda, Luis; Berthou, F.; Varela Figueroa, Nelson; Simon, B.; Gil, Lionel; Lucas, D. (Elsevier, 1999)
      Many investigators have reported an association between genetic polymorphisms of cytochromes P-450 CYP2E1, CYP1A1 or glutathione S-transferase Mu (GSTM1) and susceptibility to lung cancer. However, pronounced interethnic ...
    • Farmacogenética del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer ... 
      Quiñones Sepúlveda, Luis; Lee, Kuen; Varela Figueroa, Nelson; Escala, Mario; García, Karen; Godoy, Loreto; Castro, Andrés; Soto Labbé, Jorge; Saavedra Saavedra, Iván; Cáceres Lillo, Dante (2006)
      Pharmacogenetics is the study of genetically determined variations in the response to drugs and toxic agents, and their implications on disease. Recently, the discipline has acquired great relevancy due to the development ...
    • Farmacogenómica como herramienta fundamental para la medicina personalizada: aplicaciones en la práctica clínica 
      Quiñones Sepúlveda, Luis; Roco Arriagada, Ángela; Cayún Pellizaris, Juan; Escalante, Paula; Miranda Melo, Carla; Varela Figueroa, Nelson; Meneses, Francisca; Gallegos, Bastián; Zaruma Torres, Fausto; Lares Asseff, Ismael (Sociedad Médica de Santiago, 2017)
      Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, ...
    • Pharmacogenomics: basis and milestones 
      Cerpa Castro, Leslie; Varela Figueroa, Nelson; Martínez Olguín, Matías; Quiñones Sepúlveda, Luis (Springer, 2021)
      The genomic interindividual heterogeneity for proper pharmacotherapy remains a significant challenge for research, clinical decision-making, and the design of clinical trials. Translation of the obtained genomic information ...
    • Pharmacogenomics: challenges and future perspectives 
      Quiñones Sepúlveda, Luis; Martínez Olguín, Matías; Cerpa Castro, Leslie; Varela Figueroa, Nelson (Springer, 2021)
      Pharmacogenetics is the science of understanding how genetic variability influences drug treatment outcomes and generally refers to the effects of a single genetic marker on pharmacokinetics and pharmacodynamics of ...
    • Pharmacogenomics: genetic polymorphisms 
      Varela Figueroa, Nelson; Cerpa Castro, Leslie; Martínez Olguín, Matías; Quiñones Sepúlveda, Luis (Springer, 2021)
      It has been estimated that the human genome harbors about 30,000 protein-coding genes. Within these proteins we find transporters, metabolizing enzymes, and therapeutic drug targets. The analysis of human genomic ...
    • Pharmacokinetic polymorphisms 
      Martínez Olguín, Matías; Cerpa Castro, Leslie; Varela Figueroa, Nelson; Quiñones Sepúlveda, Luis (Springer, 2021)
      A polymorphism is a genetic variant that leads to at least two non-rare phenotypes with a frequency of 1% or greater in a population. When the variant is in a gene that codifies proteins involved in drug absorption, ...
    • Relative bioavailability study with two oral formulations of topiramate using a validated UPLC-MS/MS method 
      Saavedra Saavedra, Iván; Tamayo Carrillo, Evelyn; Gamboa, A.; Sasso Aguirre, Jaime Alfredo; Varela Figueroa, Nelson; Moreno, Iván; Marchant Lavín, Dafne; Cáceres Lillo, Dante; Quiñones Sepúlveda, Luis (2010)
      Changes in bioavailability of anticonvulsant drugs such as topiramate may cause loss of or worsened seizure control. Thus, the purpose of this study was to evaluate, in a double-blind crossover design, the bioavailability ...