Browsing by Author "Vidal, René L."

Now showing items 1-8 of 8

    • A phenolic-rich extract from ugni molinae berries reduces abnormal protein aggregation in a cellular model ... 
      Pérez Arancibia, Rodrigo Nicolás; Ordóñez, José Luis; Rivas, Alexis; Pihán, Philippe; Sagredo, Alfredo; Ahumada, Ulises; Barriga, Andrés; Seguel, Ivette; Cárdenas, César; Vidal, René L.; Hetz Flores, Claudio Andres; Delporte Vergara, Carla Luz (Public Library Science, 2021)
      Accumulation of misfolded proteins in the brain is a common hallmark of most age-related neurodegenerative diseases. Previous studies from our group identified the presence of anti-inflammatory and antioxidant compounds ...
    • ALS-linked protein disulfide isomerase variants cause motor dysfunction 
      Woehlbier, Ute; Colombo Flores, Alicia; Saaranen, Mirva J.; Pérez, Viviana; Ojeda, Jorge; Bustos, Fernando J.; Andreu, Catherine; Torres, Mauricio; Valenzuela, Vicente; Medinas Bilches, Danilo; Rozas, Pablo; Vidal, René L.; López González, Rodrigo; Salameh, Johnny; Fernández Collemann, Sara; Muñoz, Natalia; Matus, Soledad; Armisen Yáñez, Ricardo; Sagredo, Alfredo; Palma, Karina; Irrázabal, Thergiory; Almeida, Sandra; González Pérez, Paloma; Campero, Mario; Gao, Fen-Biao; Henny, Pablo; Van Zundert, Brigitte; Ruddock, Lloyd W.; Concha, Miguel L.; Henríquez, Juan P.; Brown, Robert H.; Hetz Flores, Claudio (Wiley-Blackwell, 2016)
      Disturbance of endoplasmic reticulum (ER) proteostasis is a common feature of amyotrophic lateral sclerosis (ALS). Protein disulfide isomerases (PDIs) are ER foldases identified as possible ALS biomarkers, as well as ...
    • Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1 
      Valdés, Pamela; Mercado, Gabriela; Vidal, René L.; Molina, Claudia; Parsons, Geoffrey; Court, Felipe A.; Martínez, Alexis; Galleguillos, Danny; Armentano, Donna; Schneider, Bernard L.; Hetz Flores, Claudio (CrossMark, 2014)
      Parkinson disease (PD) is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta (SNpc). Although growing evidence indicates that endoplasmic reticulum (ER) stress is a hallmark ...
    • Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration 
      Castillo, Valentina; Oñate, Maritza G.; Woehlbier, Ute; Rozas, Pablo; Andreu, Catherine; Medinas Bilches, Danilo; Valdés, Pamela; Osorio, Fabiola; Mercado, Gabriela; Vidal, René L.; Kerr, Bredford; Court, Felipe A.; Hetz Flores, Claudio (Public Library Science, 2015)
      ERp57 (also known as grp58 and PDIA3) is a protein disulfide isomerase that catalyzes disulfide bonds formation of glycoproteins as part of the calnexin and calreticulin cycle. ERp57 is markedly upregulated in most common ...
    • Marlin-1 and conventional kinesin link GABA(B) receptors to the cytoskeleton and regulate receptor transport 
      Vidal, René L.; Ramírez, Omar A.; Sandoval, Lisette; Koenig Robert, Roger; Haertel, Steffen; Couve Correa, Andrés (2007)
      The cytoskeleton and cytoskeletal motors play a fundamental role in neurotransmitter receptor trafficking, but proteins that link GABA(B) receptors (GABA(B)Rs) to the cytoskeleton have not been described. We recently ...
    • Marlin-1 is expressed ion testis and associates to the cytoskeleton and GABA(B) receptors 
      Vidal, René L.; Ramírez, Alfredo; Castro, Maite; Concha, Ilona I.; Couve Correa, Andrés (WILEY-LISS, DIV JOHN WILEY & SONS INC, 2008-02-15)
      Marlin-1 is a GABAB receptor and Jak tyrosine kinase-binding protein that also associates with RNA and microtubules. In humans and rodents, expression of Marlin-1 is predominantly restricted to the brain, but expression ...
    • Neuronal rubicon represses extracellular APP/amyloid beta deposition in Alzheimer's disease 
      Espinoza, Sandra; Grunenwald, Felipe; Gomez, Wileidy; García, Felipe; Abarzúa Catalán, Lorena; Oyarce Pezoa, Sebastián; Hernández, María Fernanda; Cortés, Bastián I.; Uhrig, Markus; Ponce de la Vega, Daniela Paz; Durán Aniotz, Claudia; Hetz Flores, Claudio Andres; San Martín Rovirosa, Carol Dazil; Cornejo Corona, Víctor Hugo; Ezquer, Fernando; Parra Ortiz, Valentina María; Behrens Pellegrino, María Isabel Ofelia; Manque, Patricio A.; Rojas Rivera, Diego; Vidal, René L.; Woehlbier, Ute; Nassif, Melissa (MDPI, 2022)
      Alzheimer's disease (AD) is the most prevalent age-associated neurodegenerative disease. A decrease in autophagy during aging contributes to brain disorders by accumulating potentially toxic substrates in neurons. Rubicon ...
    • Therapeutic potential of insulin-like growth factor 2 in Huntington's disease: controlling proteostasis to ... 
      Troncoso Escudero, Paulina Beatriz; Hetz Flores, Claudio Andrés; Vidal, René L. (Wolters Kluwer Medknow, 2021)