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Marlin-1 is expressed ion testis and associates to the cytoskeleton and GABA(B) receptors

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2008-02-15
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Vidal, René L.
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Marlin-1 is expressed ion testis and associates to the cytoskeleton and GABA(B) receptors
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Author
  • Vidal, René L.;
  • Ramírez, Alfredo;
  • Castro, Maite;
  • Concha, Ilona I.;
  • Couve Correa, Andrés;
Abstract
Marlin-1 is a GABAB receptor and Jak tyrosine kinase-binding protein that also associates with RNA and microtubules. In humans and rodents, expression of Marlin-1 is predominantly restricted to the brain, but expression in lymphoid cells has also been reported. Here, we have studied the distribution of Marlin-1 in testis and spermatozoa. Our results indicate that Marlin-1 is highly expressed in testis. The protein is abundant in spermatogonia, spermatocytes, spermatozoa, and Sertoli cells.Wealso have studied the subcellular distribution in spermatozoa. Marlin-1 is present in the tail and to a lesser degree in the head of the sperm cell. Finally, we have explored two protein interactions. Our findings demonstrate that Marlin-1 associates with a microtubule fraction and withGABAB receptors in testis suggesting that the set of protein interactions of Marlin-1 are conserved in different tissues.
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R.L.V and A.R. were funded by PhD fellowships from CONICYT and MECESUP, respectively. A.C. was funded by FONDECYT 1071001 and Iniciativa Científica Milenio ICM-P04-068-F. I.I. Concha funded by FONDECYT 1060135.
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URI: https://repositorio.uchile.cl/handle/2250/128407
ISSN: 0730-2312
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JOURNAL OF CELLULAR BIOCHEMISTRY Volume: 103 Issue: 3 Pages: 886-895 Published: FEB 15 2008
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