| Author | dc.contributor.author | Vidal, René L. | |
| Author | dc.contributor.author | Ramírez, Alfredo | es_CL |
| Author | dc.contributor.author | Castro, Maite | es_CL |
| Author | dc.contributor.author | Concha, Ilona I. | es_CL |
| Author | dc.contributor.author | Couve Correa, Andrés | es_CL |
| Admission date | dc.date.accessioned | 2010-01-28T19:22:01Z | |
| Available date | dc.date.available | 2010-01-28T19:22:01Z | |
| Publication date | dc.date.issued | 2008-02-15 | |
| Cita de ítem | dc.identifier.citation | JOURNAL OF CELLULAR BIOCHEMISTRY Volume: 103 Issue: 3 Pages: 886-895 Published: FEB 15 2008 | en_US |
| Identifier | dc.identifier.issn | 0730-2312 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/128407 | |
| Abstract | dc.description.abstract | Marlin-1 is a GABAB receptor and Jak tyrosine kinase-binding protein that also associates with RNA and
microtubules. In humans and rodents, expression of Marlin-1 is predominantly restricted to the brain, but expression in
lymphoid cells has also been reported. Here, we have studied the distribution of Marlin-1 in testis and spermatozoa. Our
results indicate that Marlin-1 is highly expressed in testis. The protein is abundant in spermatogonia, spermatocytes,
spermatozoa, and Sertoli cells.Wealso have studied the subcellular distribution in spermatozoa. Marlin-1 is present in the
tail and to a lesser degree in the head of the sperm cell. Finally, we have explored two protein interactions. Our findings
demonstrate that Marlin-1 associates with a microtubule fraction and withGABAB receptors in testis suggesting that the set
of protein interactions of Marlin-1 are conserved in different tissues. | en_US |
| Patrocinador | dc.description.sponsorship | R.L.V and A.R. were funded by PhD fellowships
from CONICYT and MECESUP, respectively.
A.C. was funded by FONDECYT 1071001 and
Iniciativa Científica Milenio ICM-P04-068-F.
I.I. Concha funded by FONDECYT 1060135. | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | WILEY-LISS, DIV JOHN WILEY & SONS INC | en_US |
| Keywords | dc.subject | testis | en_US |
| Título | dc.title | Marlin-1 is expressed ion testis and associates to the cytoskeleton and GABA(B) receptors | en_US |
| Document type | dc.type | Artículo de revista | |
