Browsing by Author "Zapata Torres, Gerald Amilcar"
Now showing items 1-20 of 27
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(SOCIEDAD CHILENA DE QUIMICA, 2004-03)The conformational preferences of a series of 1-benzyl-1,2,3,4-tetrahydroisoquinolines (norlaudanosine and coclaurine analogues) were investigated with the aid of their H-1 NMR spectra and NOESY experiments, coupled with ...
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(Socieda Chilena de Quìmica, 1997-08-01)The conformational properties of ten ring-methylated N-methyl- and N,Ndimethylanilines have been studied using 13C-NMR chemical shifts and spin-Iattice relaxation times in CDCI3, and semi-empírical (AM1) quantum-chemical ...
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(Universidad de Chile, 2023)La colitis ulcerosa (CU) es uno de los principales tipos de enfermedades inflamatorias intestinales (EII), que tiene una incidencia creciente en Chile durante los últimos años, y una etiología multifactorial que involucra: ...
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(PERGAMON-ELSEVIER SCIENCE LTD, 2008-05-01)The slightly water-soluble 5-nitroindazole derivative (5-NI) and its inclusion with either beta-cyclodextrin (beta CD) or Heptakis (2,6-di-O-methyl)-beta- cyclodextrin (DM beta CD) were investigated. The stoichiometric ...
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(Universisdad de Chile, 2002)En esta tesis, los receptores serotoninergicos 5-HT2A y 5HT2c fueron escogidos como modelos de familia mas amplia de receptores insertos en membranas y acoplados a proteínas G con el propósito de estudiar las interacciones ...
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(AMER CHEMICAL SOC, 2004-03)A number of natural and synthetic flavonoids have been assessed previously with regard to their effects on the activity of cyclin-dependent kinases (Cdk1 and -2) related to the inhibition of cell cycle progression. On the ...
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(Universidad de Chile, 2013)Los puentes de halógeno son interacciones estables entre un átomo de halógeno y otro átomo electronegativo cercano. Esta interacción se produce por la presencia del denominado agujero σ; una región positiva originada ...
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(Universidad de Chile, 2012)Estudios de funcionalización del 1H-indol, condujeron a la familia de N-{4-[4-(1H-Indol-3-carbonil)-1-piperazinil]-fenil}-arilamidas 6(a-h) (Familia I) como potenciales ligandos provistos de acción serotoninérgica en el ...
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(Universidad de Chile, 2013)Estudios de funcionalización del 1H-indol-2-acido carboxílico, condujeron a la síntesis de una familia de compuestos N-{4-[4-(1H-Indol-2-carbonil)-1-piperazinil]-fenil}- arilamidas 4(a-h) con potencial actividad ...
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(Universidad de Chile, 2009)FE65 es una proteína adaptadora que actualmente se ha relacionado con la formación del péptido β-amiloide y la hiperfosforilación de tau, procesos que se ven incrementados en pacientes con Alzheimer, probablemente como ...
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(Universidad de Chile, 2023)La síntesis orgánica ha jugado un rol fundamental en nuestra sociedad, en áreas como lo son la química médica, productos naturales, farmacéutica, entre otros. Por esto, se han tenido que desarrollar procesos que sean cada ...
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(Universidad de ChileCyberDocs, 2010)
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(SOCIEDAD CHILENA DE QUIMICA, 2004-09)Condensation of 4-methylthiobenzaldehyde with 1-nitropropane unexpectedly afforded separable amounts of both (E)- and (Z)-1-(4-methylthiophenyl)-2-nitrobutene. The H-1 and C-13 NMR spectra allowed the unequivocal assignment ...
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(SPRINGER/PLENUM PUBLISHERS, 2010-10)The formation of the complexes of galangin (GAL) with native β-cyclodextrin (βCD), and with its substituted counterparts such as dimethyl-βCD (DMβCD) and hydroxypropyl-βCD (HPβCD), was studied by fluorescence spectra in ...
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(Frontiers Media, 2021)Gastric cancer (GC) is the fifth most prevalent type of cancer worldwide. Gastric tumor cells express MICA protein, a ligand to NKG2D receptor that triggers natural killer (NK) cells effector functions for early tumor ...
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(AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, 2010-06-14)(DH E) are potent and selective competitive inhibitors of 4 2 nicotinic acetylcholine receptors (nAChRs), but little is known about the molecular determinants of the sensitivity of this receptor subtype to inhibition ...
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(Elsevier Ltd., 2008-10-25)This study reports the comparative molecular modeling, docking and dynamic simulations of human a9a10 nicotinic acetylcholine receptors complexed with acetylcholine, nicotine and a-conotoxin RgIA, using as templates the ...
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(F P GRAHAM PUBLISHING CO, 2006-08)The clinical utility of amphetamine and amphetamine analogues has been jeopardized by a number of side effects and toxicity, partly due to complex mechanisms of action. While some of the analogues have been individually ...
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(Elsevier Inc, 2008-06)Time-averaged conformations of ( )-1-[3,4-(methylenedioxy)phenyl]-2-methylaminopropane hydrochloride (MDMA, ‘‘ecstasy’’) in D2O, and of its free base and trifluoroacetate in CDCl3, were deduced from their 1H NMR spectra ...
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(Elsevier, 2013)Diels–Alder cycloaddition of 8,8-dimethylnaphthalene-1,4,5(8H)-trione with diastereomeric hydroxysulfinyldienes proceeded with high yields and good p-facial and regioselectivities. The hydroxysulfoxide moiety controls ...
