Browsing by Subject "Alzheimer’s disease"
Now showing items 1-20 of 26
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(Frontiers Media, 2020)Synaptic loss induced by soluble oligomeric forms of the amyloid beta peptide (sA beta os) is one of the earliest events in Alzheimer's disease (AD) and is thought to be the major cause of the cognitive deficits. These ...
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(Frontiers Media, 2020)Periodontal disease is a disease of tooth-supporting tissues. It is a chronic disease with inflammatory nature and infectious etiology produced by a dysbiotic subgingival microbiota that colonizes the gingivodental sulcus. ...
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(IOS Press, 2020)Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most common neurodegenerative early-onset dementias. Despite the fact that both conditions have a very distinctive clinical pattern, they present with an ...
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(Elsevier, 2021)The increased oxidative stress in the acceleration of the aging process and development of the neuronal disorder are the common feature detected in neurodegenerative illness, such as Alzheimer’s disease, Parkinson’s ...
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(COMPANY OF BIOLOGISTS LTD, 2006-10-30)A number of psychiatric and neurodegenerative disorders, such as Alzheimer’s disease, are characterized by abnormalities in the neuronal cytoskeleton. Here, we find that the enhancement in actin polymerization induced ...
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(MDPI, 2021)The role of docosahexaenoic acid (DHA) and arachidonic acid (AA) in neurogenesis and brain development throughout the life cycle is fundamental. DHA and AA are long-chain polyunsaturated fatty acids (LCPUFA) vital for ...
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(International Society for Neurochemistry, 2014)Dynamin-2 is a pleiotropic GTPase whose best-known function is related to membrane scission during vesicle budding from the plasma or Golgi membranes. In the nervous system, dynamin-2 participates in synaptic vesicle ...
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(Elsevier, 2020)Accurate early diagnosis of neurodegenerative diseases represents a growing challenge for current clinical practice. Promisingly, current tools can be complemented by computational decision-support methods to objectively ...
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(BMC, 2022)Background Alzheimer's disease is the most prevalent cause of dementia in the elderly. Neuronal death and synaptic dysfunctions are considered the main hallmarks of this disease. The latter could be directly associated to ...
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(BMC, 2020)There is an increasing role for biological markers (biomarkers) in the understanding and diagnosis of neurodegenerative disorders. The application of imaging biomarkers specifically for the in vivo investigation of ...
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(MDPI, 2021)Iron accumulation and neuroinflammation are pathological conditions found in several neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Iron and inflammation are intertwined in a ...
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(Soc Neuroscience, 2021)Recent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of negative emotions. However, the field lacks experimental designs manipulating the priming of ...
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(Dr. Dietrich Steinkopff Verlag GmbH and Co. KG, 2019)Background: Impairments in activities of daily living (ADL) are a criterion for Alzheimer’s disease (AD) dementia. However, ADL gradually decline in AD, impacting on advanced (a-ADL, complex interpersonal or social ...
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(IOP Publishing, 2020)Background: A major drawback in Alzheimer's disease (AD) is the lack of validated biomarkers for routine clinical diagnostic. We have reported earlier a novel blood biomarker, named Alz-tau (R), based on variants of platelet ...
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(MDPI, 2021)Alzheimer’s disease (AD), considered a common type of dementia, is mainly characterized by a progressive loss of memory and cognitive functions. Although its cause is multifactorial, it has been associated with the ...
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(BLACKWELL, 2009)The idea that alterations in the brain immunomodulation are critical for Alzheimer’s disease (AD) pathogenesis provides the most integrative view on this cognitive disorder, considering that converging research lines ...
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(Frontiers Research Foundation, 2017)© 2017 SanMartín, Veloso, Adasme, Lobos, Bruna, Galaz, García, Hartel, Hidalgo and Paula-Lima. Amyloid β peptide oligomers (AβOs), toxic aggregates with pivotal roles in Alzheimer’s disease, trigger persistent and low ...
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(MDPI, 2022)Recent studies suggest that cellular senescence plays a role in Alzheimer’s Disease (AD) pathogenesis. We hypothesize that cellular senescence markers might be tracked in the peripheral tissues of AD patients. Senescence ...
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Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line (SOC BIOLGIA CHILE, 2008)We have previously characterized a number of small molecule organic compounds that prevent the aggregation of the β-amyloid peptide and its neurotoxicity in hippocampal neuronal cultures. We have now evaluated the effects ...
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(Elsevier, 2020)During the last decade, the one drug-one target strategy has resulted to be inefficient in facing diseases with complex ethiology like Alzheimer's disease and many others. In this context, the multitarget paradigm has ...