Browsing by Subject "Inhibitors"

Now showing items 1-7 of 7

    • Anthraquinone Derivative Reduces Tau Oligomer Progression by Inhibiting Cysteine-Cysteine Interaction 
      Areche, Carlos; Zapata, Francisca; González, Mathias; Díaz, Esteban; Montecinos, Rubén; Hernández, Marcos; Melo, Francisco; Cornejo, Alberto (Wiley-VCH Verlag, 2019)
      Tau protein is a natively unfolded protein whose primary role is to participate in axonal transport closely associated with microtubules. Neurodegenerative disorders including Alzheimer's disease and Tauopathies involved ...
    • Autophagy mediates tumor necrosis factor-alpha-induced phenotype switching in vascular smooth muscle A7r5 cell line 
      García Miguel, Marina; Riquelme, Jaime A.; Norambuena Soto, Ignacio; Morales, Pablo E.; Sanhueza Olivares, Fernanda; Núñez Soto, Constanza Belén; Mondaca Ruff, David; Cancino Arenas, Nicole; San Martín, Alejandra; Chiong Lay, Mario (Public library science, 2018)
      Vascular smooth muscle cells (VSMC) dedifferentiation from a contractile to a synthetic phenotype contributes to atherosclerosis. Atherosclerotic tissue has a chronic inflammatory component with high levels of tumor necrosis ...
    • Estudio de costo-efectividad de profilaxis con emicizumab versus agentes hemostáticos alternativos en ... 
      Bitrán, Ricardo; Peña Ojeda, Camila Isidora; Arpóna, Paula; Loayzac, Nancy; Salasd, Katia; Villare, Carmen del; Chumpitazf, Gloria; Salinas, Virgilio (Medwave, 2022)
      Contexto La hemofilia es un trastorno hemorrágico de la coagulación que ocurre en uno de cada 5000 nacimientos masculinos. Los pacientes con hemofilia A grave no tratados tienen complicaciones hemorrágicas, incluyendo ...
    • Inhibition of RAGE axis signaling: A pharmacological challenge 
      Rojas, Armando; Morales, Miguel; Gonzalez, Ileana; Araya, Paulina (Bentham Science Publishers B.V., 2019)
      The Receptor for Advanced Glycation End Products (RAGE) is an important cell surface receptor, which belongs to the IgG super family and is now considered as a pattern recognition receptor. Because of its relevance in many ...
    • Pharmacokinetics, efficacy prediction indexes, and residue depletion of ribavirin in Atlantic salmon’s ... 
      San Martín Núñez, Betty; Muñoz Obregón, Rubén; Cornejo Kelly, Javiera; Martínez, M. A.; Araya Jordán, C.; Maddaleno Toledo, Aldo; Anadón, A. (Wiley, 2016)
      Ribavirin is an antiviral used in human medicine, but it has not been authorized for use in veterinary medicine although it is effective against infectious salmon anemia (ISA) virus, between others. In this study, we present ...
    • The fumarprotocetraric acid inhibits tau covalently, avoiding cytotoxicity of aggregates in cells 
      González, Camila; Cartagena, Constanza; Caballero, Leonardo; Melo, Francisco; Areche Medina, Carlos Alberto; Cornejo, Alberto (MDPI, 2021)
      Neurodegenerative disorders, including Tauopathies that involve tau protein, base their pathological mechanism on forming proteinaceous aggregates, which has a deleterious effect on cells triggering an inflammatory ...
    • The use of drugs in the study of vacuole morphology and trafficking to the vacuole in arabidopsis thaliana 
      Tejos, Ricardo; Osorio Navarro, Claudio; Norambuena Morales, Lorena (Humana Press, 2018)
      Chemical compounds are useful to perturb biological functions in the same way as classical genetic approaches take advantage of mutations at the DNA level to perturb gene function. The use of bioactive chemicals currently ...