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Ischemia Enhances Activation by Ca2+ and Redox Modification of Ryanodine Receptor Channels from Rat Brain Cortex
(2008)
on endoplasmic reticulum (ER) Ca 2� re-
lease have received less attention (Herna´ndez-Fonseca and
Massieu, 2005). The ER has an important role as a regulator of
intracellular [Ca 2�] in neurons (Berridge et al., 1998; Pape et
al., 2004; Verkhratsky, 2005...
12 binding to type 1 calcium re- lease channels. Antioxid Redox Signal 7:870 – 881. Aracena-Parks P, Goonasekera SA, Gilman CP, Dirksen RT, Hidalgo C, Hamilton SL (2006) Identification of cysteines involved in S-nitrosylation, S...
12 binding to type 1 calcium re- lease channels. Antioxid Redox Signal 7:870 – 881. Aracena-Parks P, Goonasekera SA, Gilman CP, Dirksen RT, Hidalgo C, Hamilton SL (2006) Identification of cysteines involved in S-nitrosylation, S...
Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation
(NATL ACAD SCIENCES, 2011-02-15)
). In particular, RyR-mediated Ca+2-induced Ca+2 re-
lease (CICR) provides amajor fraction of theCa+2 increase induced
in hippocampalCA1 spines by synaptic activity (17).High-frequency
field stimulation of primary hippocampal neurons produces Ca+2
signals primarily...
Calcium microdomains and gene expression in neurons and skeletal muscle cells
(CHURCHILL LIVINGSTONE, 2006-12)
IP3R-mediated
lease generates slower and long-lasting calcium
ins of smaller amplitude that do not induce con-
are especially prominent in cell nuclei [65–69].
muscle cells express all three IP3R isoforms;
m exhibits a particular intracellular...
S-glutathionylation decreases Mg2+ inhibition and S-nitrosylation enhances Ca2+ activation of RyR1 channels
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003-10-31)
different responses. Glutathi-
one disulfide significantly reduces the inhibitory effect
of Mg2� without altering Ca2� activation of release ki-
netics, whereas NOR-3 enhances Ca2� activation of re-
lease kinetics without altering Mg2� inhibition. Incuba...
High-Frequency Field Stimulation of Primary Neurons Enhances Ryanodine Receptor-Mediated Ca2+ Release and Generates Hydrogen Peroxide, Which Jointly Stimulate NF-kB Activity
(2011)
RyR redox modification promotes Ca2þ re-
lease, which in turn enhances extracellular-signal related ki-
nases 1/2 (ERK1=2) and cAMP response element-binding
protein (CREB) phosphorylation (45).
Primary hippocampal cells exposed to electrical field...
Glucose-Dependent Insulin Secretion in Pancreatic beta-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors
(Public Library Science, 2015)
, where addition of exogenous
H2O2 promotes RyR redox modifications and specifically stimulates RyR-mediated Ca
2+ re-
lease [30, 59].
Additionally, we found that 100 μMH2O2 disrupted GSIS, confirming previous reports in
rat islets [29] and mouse...
Amyloid beta-Peptide Oligomers Stimulate RyR-Mediated Ca(2+) Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF
(MARY ANN LIEBERT INC, 2011-04)
via RyR-mediated
CICR. In addition, the stimulation of RyR-mediated Ca2þ re-
lease by 4-CMC was completely prevented by preincubation
of primary cultures with 10 mM NAC for 60 min (Supple-
mentary Fig. S3C). These results confirm that reducing agents...