Browsing by Subject "Tauopathies"

Now showing items 1-3 of 3

    • Mechanisms of tau self-aggregation and neurotoxicity 
      Farías,; Cornejo,; Jiménez,; Guzmán,; Maccioni, (2011)
      Pathological tau protein aggregates can be found in brain of patients with some of the neurodegenerative diseases collectively known as tauopathies, which include Alzheimer's disease (AD). Since tau post-translational ...
    • Neuroimmune tau mechanisms: their role in the progression of neuronal degeneration 
      Cortes, Nicole; Andrade, Victor; Guzmán Martínez, Leonardo; Estrella, Matías; Maccioni Baraona, Ricardo (MDPI, 2018-04)
      Progressive neurodegenerative pathologies in aged populations are an issue of major concern worldwide. The microtubule-associated protein tau is able to self-aggregate to form abnormal supramolecular structures that include ...
    • The fumarprotocetraric acid inhibits tau covalently, avoiding cytotoxicity of aggregates in cells 
      González, Camila; Cartagena, Constanza; Caballero, Leonardo; Melo, Francisco; Areche Medina, Carlos Alberto; Cornejo, Alberto (MDPI, 2021)
      Neurodegenerative disorders, including Tauopathies that involve tau protein, base their pathological mechanism on forming proteinaceous aggregates, which has a deleterious effect on cells triggering an inflammatory ...