Browsing by Author "Quest, Andrew Frederick Geoffery"

Now showing items 1-8 of 8

    • Extracellular vesicles as mediators of cancer disease and as nanosystems in theranostic applications 
      Burgos Ravanal, Renato Alberto; Campos González, América Vanessa; Díaz Vesga, Magda Carolina; González, María Fernanda; León, Daniela; Lobos González, Lorena; Leyton Campos, Lisette; Kogan, Marcelo Javier; Quest, Andrew Frederick Geoffery (MDPI, 2021)
      Simple Summary Cancer is the second leading cause of death in humans, and in 2020, 9.8 million cancer-related deaths were reported worldwide. In the last 20 years, it has become apparent that small vesicles released by ...
    • Mitochondrial dysfunction and the glycolytic switch induced by caveolin-1 phosphorylation promote cancer ... 
      Díaz Valdivia, Natalia; Simón, Layla; Díaz, Jorge; Martínez Meza, Samuel; López Contreras, Pamela; Burgos Ravanal, Renato; Pérez, Viviana; Frei, Balz; Leyton Campos, Lisette; Quest, Andrew Frederick Geoffery (MDPI, 2022)
      Simple Summary Caveolin-1 (CAV1) is a membrane protein that has been attributed a dual role in cancer, acting at early stages as a tumor suppressor and in later stages of the disease as a promoter of metastasis. In the ...
    • Papel de la Policistina-1 en la regulación de BIN1 y la formación de la ultraestructura de los túbulos ... 
      Díaz Vesga, Magda Carolina (Universidad de Chile, 2022)
      La Insuficiencia cardíaca (IC) es la incapacidad del corazón de generar un adecuado gasto cardíaco de acuerdo a la demanda requerida por el organismo. Uno de los cambios estructurales que presenta el corazón durante la ...
    • Perspectives on organelle interaction, protein dysregulation, and cancer disease 
      Díaz, Paula; Sandoval Bórquez, Alejandra María Loreto; Bravo Sagua, Roberto Francisco; Quest, Andrew Frederick Geoffery; Lavandero González, Sergio Alejandro (Frontiers Media, 2021)
      In recent decades, compelling evidence has emerged showing that organelles are not static structures but rather form a highly dynamic cellular network and exchange information through membrane contact sites. Although ...
    • Porphyromonas gingivalis-Helicobacter pylori coincubation enhances Porphyromonas gingivalis virulence and ... 
      Soto Mendoza, Cristopher; Rojas, Victoria; Yáñez, Lucas; Hidalgo, Antonio; Olivera, Marcela; Pacheco, Martín; Venegas Díaz, Darna Angelina; Salinas, Daniela; Bravo, Denisse; Quest, Andrew Frederick Geoffery (Taylor & Francis, 2022)
      Background: Porphyromonas gingivalis is part of the subgingival biofilm and a keystone species in the development of periodontitis. Interactions between P.gingivalis and other bacteria in biofilms have been shown to ...
    • Role of the pro-inflammatory tumor microenvironment in extracellular vesicle-mediated transfer of therapy ... 
      Simón, Layla Yamila; Sanhueza, Sofía; Gaete Ramírez, Belén; Varas Godoy, Manuel Alejandro; Quest, Andrew Frederick Geoffery (Frontiers Media, 2022)
      Advances in our understanding of cancer biology have contributed to generating different treatments to improve the survival of cancer patients. However, although initially most of the therapies are effective, relapse and ...
    • Small RNA expression profiling reveals hsa-miR-181d-5p downregulation associated with TNF-α overexpression ... 
      Castro Masso, Isabel Verónica; Carvajal Garcés, Patricia Alejandra; Jara, Daniela; Aguilera, Sergio; Heathcote Pérez, Benjamín Norman; Barrera, María José; Aliaga Tobar, Víctor Manuel; Maracaja Coutinho, Vinicius; Urzúa Tobar, Ulises; Quest, Andrew Frederick Geoffery; González, Sergio; Claudio, Molina; Hermoso, Marcela Alejandra; González Burgos, María Julieta (Frontiers Media, 2022)
      MicroRNAs (miRNAs) are small non-coding RNAs (sRNA), that alter gene expression by binding to target messenger RNAs (mRNAs) and repressing translation. Dysregulated miRNA expression has been implicated in the pathogenesis ...
    • Thy-1 (CD90)-induced metastatic cancer cell migration and invasion are β3 integrin-dependent and involve a ... 
      Brenet Rivas, Marianne del Pilar; Martínez, Samuel; Pérez Núñez, Ramón; Pérez González, Leonardo Andrés; Contreras, Pamela; Díaz, Jorge; Ávalos, Ana María; Schneider, Pascal; Quest, Andrew Frederick Geoffery; Leyton Campos, Lisette (Frontiers Media, 2021)
      Cancer cell adhesion to the vascular endothelium is an important step in tumor metastasis. Thy-1 (CD90), a cell adhesion molecule expressed in activated endothelial cells, has been implicated in melanoma metastasis by ...