Browsing by Subject "Immunotherapy"

Now showing items 1-12 of 12

    • A heat-shocked melanoma cell lysate vaccine enhances tumor infiltration by prototypic effector T cells ... 
      Gleisner Muñoz, María Alejandra; Pereda Ramos, Cristián; Tittarelli Elaskar, Andrés; Navarrete Sánchez, Mariela; Fuentes Villegas, Camila; Ávalos, Ignacio; Tempio Sepúlveda, Fabián; Araya, Juan Pablo; Becker, María Inés; González Bergas, Fermín; López Nitsche, Mercedes; Salazar Onfray, Flavio (BMJ, 2020)
      Background Immune checkpoint blocker (ICB) therapy has shown survival benefits for some patients with cancer. Nevertheless, many individuals remain refractory or acquire resistance to treatment, motivating the exploration of ...
    • COVID-19 in MS and NMOSD: A multicentric online national survey in Chile 
      Ciampi, Ethel; Uribe San Martín, Reinaldo; Soler, Bernardita; Fernández, Ramiro; García, Pía; Navarrete Asenjo, Claudio; Tirapegui, José Miguel; Torres, Rubén; Polanco, Juan; Suárez, Felipe; Cuello, María José; Cárcamo, Claudia B. (Elsevier, 2020)
    • Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote Antigen-Specific Tolerogenic ... 
      Maggi, Jaxaira; Schinnerling, Katina; Pesce Reyes, Bárbara; Hilkens, Catharien M.; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (Frontiers Media, 2016)
      Tolerogenic dendritic cells (DCs) are a promising tool to control T cell-mediated autoimmunity. Here, we evaluate the ability of dexamethasone-modulated and monophosphoryl lipid A (MPLA)-activated DCs [MPLA-tolerogenic DCs ...
    • Enzymatic protein biopolymers as a tool to synthetize eukaryotic messenger Ribonucleic Acid (mRNA) with ... 
      Urbina Donoso, Fabiola; Morales Pison, Sebastián; Maldonado Maldonado, Edio (MDPI, 2020)
      Multi-subunit enzymes are protein biopolymers that are involved in many cellular processes. The enzyme that carries out the process of transcription of mRNAs is RNA polymerase II (RNAPII), which is a multi-subunit enzyme ...
    • Immunodominant role of CCHA subunit of Concholepas hemocyanin is associated with unique biochemical properties 
      Becker, María Inés; Fuentes, Alejandra; Del Campo, Miguel; Manubens, Augusto; Nova, Esteban; Oliva, Harold; Faunes, Fernando; Valenzuela, María Antonieta; Campos Vallette, Marcelo; Aliaga, Alvaro E.; Ferreira, Jorge; Ioannes, Alfredo de; Ioannes, Pablo de; Moltedo, Br (2009)
      Hemocyanin, the oxygen transporter metallo-glycoprotein from mollusks, shows strong relationship between its notable structural features and intrinsic immunomodulatory effects. Here we investigated the individual contribution ...
    • Neoadjuvant immunotherapy for muscle invasive urothelial bladder carcinoma: will it change current standards? 
      Renner, Alex; Burotto, Mauricio; Valdés, José Miguel; Román Sobarzo, Juan Carlos; Walton Díaz, Annerleim Nylsello (SAGE, 2021)
      Immunotherapy, in the form of immune checkpoint inhibitors (ICI), has shown activity in metastatic urothelial bladder carcinoma, resulting in the approval of several ICI agents in the first- and second-line settings. ...
    • Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases 
      Mackern-Oberti, Juan Pablo; Llanos, Carolina; Vega, Fabián; Salazar Onfray, Flavio; Riedel, Claudia A.; Bueno, Susan M.; Kalergis, Alexis M. (Elsevier, 2015)
      Dendritic cells (DCs) play a key role in the activation of the immune response against pathogens, as well as in the modulation of peripheral tolerance to self-antigens (Ags). Furthermore, an imbalance in the activating/inhibitory ...
    • The role of regulatory T lymphocytes in the induced immune response mediated by biological vaccines 
      López, Mercedes; Aguilera, Raquel; Pérez Núñez, Claudio; Mendoza Naranjo, Ariadna; Pereda, Cristian; Ramirez, Marcos; Ferrada, Carlos; Aguillón Gutiérrez, Juan Carlos; Salazar Onfray, Flavio (Elsevier GmbH, 2006)
      Immunotherapy has become a novel therapeutic alternative for various kinds of tumours. Recently, we have finalized the first phase I clinical study in Chile for the treatment of advanced malignant melanoma, using dendritic ...
    • Therapeutic potential of hyporesponsive CD4(+) T cells in autoimmunity 
      Maggi, Jaxaira; Schafer, Carolina; Ubilla Olguín, Gabriela; Catalán Martina, Diego; Schinnerling, Katina; Aguillón Gutiérrez, Juan Carlos (Frontiers Media, 2015)
      The interaction between dendritic cells (DCs) and T cells is crucial on immunity or tolerance induction. In an immature or semi-mature state, DCs induce tolerance through T-cell deletion, generation of regulatory T cells, ...
    • Therapeutic potential of hyporesponsive CD4+ T cells in autoimmunity 
      Maggi, Jaxaira; Schafer, Carolina; Ubilla Olguín, Gabriela; Catalán Martina, Diego; Schinnerling, Katina; Aguillón Gutiérrez, Juan Carlos (Frontiers Media S.A., 2015)
      © 2015 Maggi, Schafer, Ubilla-Olguín, Catalán, Schinnerling and Aguillón. The interaction between dendritic cells (DCs) and T cells is crucial on immunity or tolerance induction. In an immature or semi-mature state, DCs ...
    • Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes ... 
      Tittarelli, Andrés; González, Fermín E.; Pereda, Cristián; Mora, Gabriela; Muñoz, Leonel; Saffie, Carlos; García, Tamara; Díaz, David; Falcón, Cristián; Hermoso, Marcela; López, Mercedes N.; Salazar Onfray, Flavio (2012)
      Toll-like receptor 4 (TLR4) is expressed on dendritic cells (DCs), sensing environmental danger molecules that induce their activation and maturation. Recently, we reported a method for the production of therapeutic DCs ...
    • Tumor lysate-based vaccines: on the road to immunotherapy for gallbladder cancer 
      Rojas-Sepúlveda, Daniel; Tittarelli, Andrés; Gleisner, María Alejandra; Ávalos, Ignacio; Pereda, Cristián; Gallegos, Iván; González, Fermín Eduardo; López, Mercedes Natalia; Butte, Jean Michel; Roa, Juan; Fluxá, Paula; Salazar Onfray, Flavio (Springer Science and Business Media Deutschland GmbH, 2018)
      © 2018, The Author(s). Immunotherapy based on checkpoint blockers has proven survival benefits in patients with melanoma and other malignancies. Nevertheless, a significant proportion of treated patients remains refractory, ...