Browsing by Author "López Alarcón, Camilo"
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Valenzuela, V.; Santander, P.; Camargo Grandón, Rodrigo; Squella Serrano, Juan; López Alarcón, Camilo; Núñez Vergara, Luis (TAYLOR & FRANCIS, 2004-07)In the present paper, a direct quenching of radical species by a number of synthesized nitrosoaryl 1,4-dihydropyridines and their parent nitroaryl 1,4-dihydropyridines was determined in aqueous media at pH 7.4. These two ...
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Bridi, R.; Troncoso, M. J.; Folch Cano, Christian; Fuentes, J. Rodrigo; Speisky Cosoy, Hernán; López Alarcón, Camilo (Springer New York LLC, 2014)© 2014, Springer Science+Business Media New York. The use of a Folin–Ciocalteu (FC) assay to assess total phenolics in certain foods may be limited by the inability of this assay to discriminate between phenolics and ...
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Atala, E.; Aspée, Alexis; Speisky Cosoy, Hernán; Lissi Gervaso, Eduardo A.; López Alarcón, Camilo (2013)A novel ORAC (oxygen radical absorbance capacity) assay to assess antioxidant capacity of phenolic compounds in near-gastric conditions (pH 2.0) is presented. AAPH (2,2'-azo-bis(2-amidinopropane)dihydrochloride) was used ...
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López Alarcón, Camilo; Speisky Cosoy, Hernán; Lissi Gervaso, Eduardo (Society of Biology of Chile, 2007)The antioxidant effect of 5-Aminosalicylic acid (5-ASA) on copper-mediated LDL oxidation was followed either by the emitted chemiluminiscence (CL) or by UV-vis spectroscopy. 5-ASA addition extends the lag phase in a ...
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Speisky Cosoy, Hernán; Rocco, Claudia; Carrasco, Catalina; Lissi Gervaso, Eduardo A.; López Alarcón, Camilo (JOHN WILEY, 2006-06)Herbal tea consumption is deeply and widely rooted amongst South-American populations. In view of the involvement of oxygen- and nitrogen-reactive species in the ethiogenesis of several diseases, the antioxidant properties ...
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Atala, E.; Vásquez, L.; Speisky Cosoy, Hernán; Lissi Gervaso, Eduardo A.; López Alarcón, Camilo (2009)An oxygen radical absorbance capacity (ORAC) method based on pyrogallol red bleaching (ORAC-PGR) was used to evaluate the scavenging activity of berry extracts (blackberry, blueberry, and raspberry). Among berry extracts, ...
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Arenas, Andrea; López Alarcón, Camilo; Kogan Bocian, Marcelo; Lissi Gervaso, Eduardo A.; Davies, Michael; Silva, Eduardo (2013)Chemical and structural alterations to lysozyme (LYSO), glucose 6-phosphate dehydrogenase (G6PD), and bovine eye lens proteins (BLP) promoted by peroxyl radicals generated by the thermal decomposition of 2,2′-azobis(2 ...
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Speisky Cosoy, Hernán; Gómez, Maritza; Carrasco Pozo, Catalina; Pastene, Edgar; López Alarcón, Camilo; Olea Azar, Claudio (2008)Cu(2+) ions and and GSH molecules interact swiftly to form the complex Cu(I)–glutathione. We investigated the potential capacity of such complex to reduce molecular oxygen. The addition of SOD to a solution containing ...
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López Alarcón, Camilo; Squella Serrano, Juan; Núñez Vergara, Luis; Báez Guerrero, Hernán; Camargo Grandón, Rodrigo (JOHN WILEY, 2002)A gas chromatography/mass spectrometry (GC/MS) method for the qualitative and quantitative determination of the calcium-channel antagonists C-4-substituted 1,4-dihydropyridines, and their corresponding N-ethyl derivatives, ...
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Speisky Cosoy, Hernán; Gómez, Maritza; Burgos Bravo, Francesca; López Alarcón, Camilo; Jullian Matthaei, Carolina; Olea Azar, Claudio; Aliaga, Margarita E. (PERGAMON-ELSEVIER SCIENCE LTD, 2009-03-01)The interaction between Cu2+ ions and GSH molecules leads to the swift formation of the physiologically occurring Cu(I)-[GSH](2) complex. Recently, we reported that this complex is able to reduce molecular oxygen into ...
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López Alarcón, Camilo; Lissi, E.; Hoffmann, P.; Mella, J.; Pessoa Mahana, Carlos David; Speisky Cosoy, Hernán; Möller, M.; Ferrer-Sueta, G.; Denicola, A. (2011)The reaction of 5-aminosalicylic acid (5-ASA) with nitrous acid has been studied at low pH under conditions that simulate a gastric environment. The course of the reaction was followed by UV-visible and fluorescence ...
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Letelier Muñoz, María Eugenia; Entrala Alrruiz, Paz Andrea; López Alarcón, Camilo; González Lira, Víctor; Molina Berríos, Alfredo Enrique; Cortés Troncoso, Juan; Jara Sandoval, José; Santander, P.; Núñez Vergara, Luis (PERGAMON-ELSEVIER SCIENCE, 2007-12)1,4-Dihydropyridines (DHPs) used in the treatment of cardiovascular diseases, are calcium channel antagonists and also antioxidant agents. These drugs are metabolized through cytochrome P-450 oxidative system, majority ...
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Faúndez, M.; Rojas, M.; Bohle, P.; Reyes, C.; Letelier, M. E.; Aliaga, M. E.; Speisky Cosoy, Hernán; Lissi Gervaso, Eduardo A.; López Alarcón, Camilo (2011)The bleaching of the pyrogallol red (PGR) dye mediated by superoxide anion radicals (O2-) generated from the xanthine/xanthine oxidase system (X/XO) was studied by UV-visible spectrophotometry. The absorption band (at 540 ...
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López Alarcón, Camilo; Rocco Klein, Claudio Alberto; Lissi Gervaso, Eduardo A.; Carrasco, C.; Squella Serrano, Juan; Núñez Vergara, Luis; Speisky Cosoy, Hernán (SPRINGER/PLENUM PUBLISHERS, 2005-10)Purpose. The aims of the study are to analyze the interaction between 5-aminosalicylic acid (5-ASA) and peroxyl radicals and to evaluate the effect of some endogenous compounds such as ascorbic acid and amino acids on the ...
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López Alarcón, Camilo; Navarrete Encina, Patricio; Camargo Grandón, Rodrigo; Squella Serrano, Juan; Núñez Vergara, Luis (AMER CHEMICAL SOC, 2003-02)A series of C4-substituted 1,4-dihydropyridines (DHP) with either secondary or tertiary nitrogen in the dihydropyridine ring were synthesized. All of these compounds together with some commercial DHP derivatives were tested ...
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López Alarcón, Camilo; Speisky Cosoy, Hernán; Squella Serrano, Juan; Olea Azar, Claudio; Camargo Grandón, Rodrigo; Núñez Vergara, Luis (KLUWER ACADEMIC/PLENUM PUBL, 2004-10)Purpose. To study the reactivity of C4-substituted 1,4-dihydropyridines (1,4-DHP), with either secondary or tertiary nitrogen in the dihydropyridine ring, toward SIN-1-derived peroxynitrite in aqueous media at pH 7.4. Methods. ...
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Aliaga, Margarita E.; López Alarcón, Camilo; Barriga, Germán; Olea Azar, Claudio; Speisky Cosoy, Hernán (2010)Prompted by the recently reported capacity of the physiologically occurring Cu(I)-[glutathione]2 complex (Cu(I)-[GSH)]2) to reduce oxygen, the effect of various GSH-binding metals (Co2+, Cd2+, Zn2+, Pb2+, Al3+, Hg2+ and ...
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Aliaga, Margarita E.; López Alarcón, Camilo; García Río, Luis; Martín-Pastor, Manuel; Speisky Cosoy, Hernán (2012)The intracellularly-occurring Cu(I)-glutathione complex (Cu(I)-[GSH] 2) has the ability to reduce molecular oxygen into superoxide. Removal of such radicals leads to the irreversible conversion of Cu(I)-[GSH] 2 into the ...
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Speisky Cosoy, Hernán; López Alarcón, Camilo; Olea Azar, Claudio; Sandoval-Acua, Cristian; Aliaga, Margarita E. (2011)The physiologically occurring copper-glutathione complex, [Cu(I)-[GSH]2], has the ability to react continually with oxygen, generating superoxide anions (O 2 -). We addressed here the effects that superoxide removal has ...
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López Alarcón, Camilo; Squella Serrano, Juan; Miranda, Dante; Núñez Vergara, Luis (WILEY-V C H VERLAG GMBH, 2004-04)Spectroelectrochemical and HPLC characterization of the electrochemical oxidation in aqueous medium of a series of six N-1 and C-4 substituted 1,4-dihydropyridines is presented. Based on the analysis of spectra obtained ...