Browsing by Author "Faúndez, Mario"

Now showing items 1-6 of 6

    • Copper modifies liver microsomal UDP-glucuronyltransferase activity through different and opposite mechanisms 
      Letelier Muñoz, María Eugenia; Lagos, Fernando; Faúndez, Mario; Miranda, Dante; Montoya, Margarita; Aracena Parks, Paula; González Lira, Víctor (ELSEVIER IRELAND LTD, 2007-04)
      Treatment of hepatic microsomes with Fe3+/ascorbate activates UDP-glucuronyltransferase (UGT), a phenomenon totally prevented and reversed by reducing agents. At #2;M concentrations, iron and copper ions catalyze the ...
    • Evaluation of the antioxidant properties and effects on the biotransformation of commercial herbal preparations ... 
      Letelier, María Eugenia; Cortes, Juan; Lepe, Ana; Jara, José; Molina Berríos, Alfredo; Rodriguez, Carmen; Iturra-Montecinos, Pablo; Faúndez, Mario (2009)
      The antioxidant herbal ingredients are xenobiotics for animals, many of them must be biotransformed to be eliminated, especially lipophilic compounds. Biotransformation of such xenobiotics- occurs mainly in the hepatic ...
    • Inhibition of cytosolic glutathione S-transferase activity from rat liver by copper 
      Letelier Muñoz, María Eugenia; Martínez, M.; González Lira, Víctor; Faúndez, Mario; Aracena Parks, Paula (ELSEVIER, 2006-12-01)
      H2O2 inactivation of particular GST isoforms has been reported, with no information regarding the overall effect of other ROS on cytosolic GST activity. The present work describes the inactivation of total cytosolic GST ...
    • New pyridone-based derivatives as cannabinoid receptor type 2 agonists 
      Faúndez Parraguez, Manuel; Alarcón Miranda, Carlos; Cho, Young Hwa; Pessoa Mahana, Hernan Armando; Gallardo Garrido, Carlos; Chung, Hery; Faúndez, Mario; Pessoa Mahana, David (MDPI, 2021)
      The activation of the human cannabinoid receptor type II (CB2R) is known to mediate analgesic and anti-inflammatory processes without the central adverse effects related to cannabinoid receptor type I (CB1R). In this work ...
    • Possible mechanisms underlying copper-induced damage in biological membranes leading to cellular toxicity 
      Letelier Muñoz, María Eugenia; Lepe, Ana María; Faúndez, Mario; Salazar, Julia; Marín Catalán, Rigoberto; Aracena Parks, Paula; Speisky Cosoy, Hernán (ELSEVIER SCI IRELAND, 2005-01-15)
      It is generally accepted that copper toxicity is a consequence of the generation of reactive oxygen species (ROS) by copper ions via Fenton or Haber-Weiss reactions. Copper ions display high affinity for thiol and amino ...
    • Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core 
      Méndez-Rojas, Claudio; Quiroz, Gabriel; Faúndez, Mario; Gallardo Garrido, Carlos Andrés; Pessoa Mahana, Carlos David; Chung, Hery; Gallardo Toledo, Eduardo; Saitz Barría, Claudio; Araya Maturana, Ramiro; Kogan Bocian, Marcelo; Zúñiga López, María C.; Iturriaga-Vásquez, Patricio; (Wiley-VCH Verlag, 2018)
      © 2018 Deutsche Pharmazeutische Gesellschaft With the purpose of expanding the structural variety of chemical compounds available as pharmacological tools for the treatment of Alzheimer's disease, we synthesized and evaluated ...