Browsing by Author "Gillette, Thomas G."
Now showing items 1-5 of 5
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Pedrozo Cibils, Zully; Torrealba, Natalia; Fernández, Carolina; Gatica, Damián; Toro, Barbra; Quiroga, Clara; Rodríguez, Andrea E.; Sánchez, Gina; Gillette, Thomas G.; Hill, Joseph A.; Donoso Laurent, Paulina; Lavandero González, Sergio (the European Society of Cardiology, 2013)Aims Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of soluble cytosolic proteins bearing the sequence KFERQ. These proteins are targeted by chaperones and delivered to lysosomes where ...
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Luo, Yuxuan; Jiang, Nan; May, Herman I.; Luo, Xiang; Ferdous, Anwerul; Schiattarella, Gabriele G.; Chen, Guihao; Li, Qinfeng; Li, Chao; Rothermel, Beverly A.; Jiang, Dingsheng; Lavandero González, Sergio Alejandro; Gillette, Thomas G.; Hill, Joseph A. (Lippincott Williams & Wilkins, 2021)Background: Cardiac hypertrophy is an independent risk factor for heart failure, a leading cause of morbidity and mortality globally. The calcineurin/NFAT (nuclear factor of activated T cells) pathway and the MAPK ...
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Morales, Cyndi R.; Li, Dan L.; Pedrozo Cibils, Zully; May, Herman I.; Jiang, Nan; Kyrychenko, Viktoriia; Cho, Geoffrey; Kim, Soo Young; Wang, Zhao V.; Rotter, David; Rothermel, Beverly A.; Schneider, Jay W.; Lavandero González, Sergio; Gillette, Thomas G.; Hill, Joseph A. (Amer Assoc Advancement Science, 2016)Altering chromatin structure through histone posttranslational modifications has emerged as a key driver of transcriptional responses in cells. Modulation of these transcriptional responses by pharmacological inhibition ...
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Battiprolu, Pavan K.; Hojayev, Berdymammet; Jiang, Nan; Wang, Zhao V.; Luo, Xiang; Iglewski, Myriam; Shelton, John M.; Gerard, Robert D.; Rothermel, Beverly A.; Gillette, Thomas G.; Lavandero González, Sergio; Hill, Joseph A. (AMER SOC CLINICAL INVESTIGATION INC, 2012-03)The leading cause of death in diabetic patients is cardiovascular disease; diabetic cardiomyopathy is typified by alterations in cardiac morphology and function, independent of hypertension or coronary disease. However, ...
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Wang, Zhao V.; Deng, Yingfeng; Gao, Ningguo; Pedrozo Cibils, Zully; Li, Dan L.; Morales, Cyndi R.; Criollo Céspedes, Alfredo; Luo, Xiang; Tan, Wei; Jiang, Nan; Lehrman, Mark A.; Rothermel, Beverly A.; Lee, Ann Hwee; Lavandero González, Sergio; Mammen, Pradeep P .A.; Ferdous, Anwarul; Gillette, Thomas G.; Scherer, Philipp E.; Hill, Joseph A. (Elsevier, 2014-03-13)The hexosamine biosynthetic pathway (HBP) generates uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) for glycan synthesis and O-linked GlcNAc (O-GlcNAc) protein modifications. Despite the established role of the ...