Browsing by Author "Hetz Flores, Claudio"

Now showing items 1-4 of 4

    • Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons 
      Klein, Andres; Maldonado, Carola; Vargas, Lina M.; Gonzalez, Marcela; Robledo, Fermín; Perez de Arce, Karen; Muñoz, Francisco J.; Hetz Flores, Claudio; Alvarez, Alejandra R.; Zanlungo, Silvana (2011)
      Niemann-Pick type C (NPC) is a neurodegenerative disease characterized by the intralysosomal accumulation of cholesterol leading to neuronal apoptosis. We have previously reported the activation of the c-Abl/p73 proapoptotic ...
    • Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis 
      Nassif, Melissa; Valenzuela, Vicente; Rojas Rivera, Diego; Vidal, René; Matus, Soledad; Castillo, Karen; Fuentealba, Yerko; Kroemer, Guido; Levine, Beth; Hetz Flores, Claudio (Taylor and Francis Inc., 2014)
      Pharmacological activation of autophagy is becoming an attractive strategy to induce the selective degradation of aggregate-prone proteins. Recent evidence also suggests that autophagy impairment may underlie the pathogenesis ...
    • Stressing out the ER: A role of the unfolded protein response in prion-related disorders 
      Hetz Flores, Claudio; Soto, Claudio (2006)
      Transmissible Spongiform Encephalopathies are fatal and infectious neurodegenerative diseases characterized by extensive neuronal apoptosis and the accumulation of an abnormally folded form of the cellular prion protein ...
    • Targeting autophagy in neurodegenerative diseases 
      Vidal, René L.; Matus, Soledad; Bargsted, Leslie; Hetz Flores, Claudio (Elsevier Ltd, 2014)
      © 2014 Elsevier B.V. All rights reserved. The most prevalent neurodegenerative disorders involve protein misfolding and the aggregation of specific proteins. Autophagy is becoming an attractive target to treat neurodegenerative ...