Browsing by Author "Paris Pizarro, Irmgard"

Now showing items 1-3 of 3

    • Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome ... 
      Paris Pizarro, Irmgard; Dagnino Subiabre, Alexies; Marcelain Cubillos, Katherine; Bennett, L. B.; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Olea Azar, Claudio; Segura Aguilar, Juan (BLACKWELL SCIENCE LTD, 2001-04)
      The mechanism of copper (Cu) neurotoxicity was studied in the RCSN-3 neuronal dopaminergic cell line, derived from substantia nigra of an adult rat. The formation of a Cu-dopamine complex was accompanied by oxidation of ...
    • Dopamine-dependent iron toxicity in cells derived from rat hypothalamus 
      Paris Pizarro, Irmgard; Martínez Alvarado, P.; Cárdenas, S.; Pérez Pastene, C.; Graumann, Rebecca; Fuentes, P.; Olea Azar, Claudio; Caviedes Fernández, Pablo; Segura Aguilar, Juan (AMER CHEMICAL SOC, 2005-03)
      We report a new and specific mechanism for iron-mediated neurotoxicity using RCHT cells, which were derived from rat hypothalamus. RCHT cells exhibit immunofluorescent-positive markers for dopamine beta-hydroxylase and the ...
    • Possible role of salsolinol quinone methide in the decrease of RCSN-3 cell survival 
      Martínez Alvarado, P.; Dagnino Subiabre, Alexies; Paris Pizarro, Irmgard; Metodiewa, D.; Welch, C. J.; Olea Azar, Claudio; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Segura Aguilar, Juan (ACADEMIC PRESS INC, 2001-05-25)
      The endogenous dopamine-derived neurotoxin salsolinol was found to decrease survival in the dopaminergic neuronal cell line RCSN-3, derived from adult rat substantia nigra in a concentration-dependent manner (208 muM ...