Browsing by Author "Perie, J."
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Bollo Dragnic, Soledad; Núñez Vergara, Luis; Bontá, M.; Chauviere, G.; Perie, J.; Squella Serrano, Juan (ELSEVIER SCIENCE, 2001-09-21)Megazol (2-amino-5-(1-methyl-5-nitro-2-imdazolyl)-1,3,4-thiadiazol, CAS 19622-55-0) and related nitroimidazole compounds are being tested as antichagasic drugs. Little is known on the mode of action of megazol. However, ...
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Bontá, M.; Chauviere, G.; Perie, J.; Núñez Vergara, Luis; Squella Serrano, Juan (PERGAMON-ELSEVIER SCIENCE, 2002-09-25)We have studied the electrochemical reduction of some nitroimidazoles such as megazol(2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazol, CAS 19622-55-0) and two related derivatives in aprotic media (100% DMF, 0.1 ...
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Bollo Dragnic, Soledad; Núñez Vergara, Luis; Bontá, M.; Chauviere, G.; Perie, J.; Squella Serrano, Juan (WILEY-V C H VERLAG GMBH, 2001-07)Megazol (2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazol, CAS 19622-55-0), a highly active compound used against several of Trypanosoma cruzi, the causative agent of Chagas disease, is electrochemically studied ...
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Maya Arango, Juan; Bollo Dragnic, Soledad; Núñez Vergara, Luis; Squella Serrano, Juan; Repetto Scaramelli, Yolanda; Morello Casté, Antonio; Perie, J.; Chauviere, G. (PERGAMON-ELSEVIER SCIENCE, 2003-03-15)With the aim of determining the actual target(s) of nitro-group bearing compounds considered as possible leads for the development of drugs against Chagas' disease, we studied in parallel nitrofurans and nitroimidazoles. ...
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Bollo Dragnic, Soledad; Núñez Vergara, Luis; Martínez, C.; Chauviere, G.; Perie, J.; Squella Serrano, Juan (WILEY-V C H VERLAG GMBH, 2003-01)The electrochemical behavior of 2-(5-amino- 1,3,4-oxadiazolyl)-5-nitrofuran (NF359) and its comparison with well known drugs such as nifurtimox (NFX) and nitrofurazone (NFZ) in protic, mixed and aprotic media by cyclic ...