Browsing by Author "Uriarte, Eugenio"

Now showing items 1-6 of 6

    • Chemical and biological analysis of 4-acyloxy-3-nitrocoumarins as trypanocidal agents 
      Salgado, Francisco; Moncada Basualto, Mauricio Javier; Pozo Martínez, Josué Santiago; Liempi, Ana; Kemmerling Weis, Ulrike; Maya Arango, Juan Diego; Jaque Olmedo, Pablo César; Borges, Fernanda; Uriarte, Eugenio; Matos, María J.; Olea Azar, Claudio Alberto (Elsevier, 2021)
      Chagas disease is the most widespread contagious tropical disease in Latin America, being an important public health problem. Treatments against this disease are still very ineffective, presenting several side effects. ...
    • Facing Chagas' Disease: Trypanocidal Properties of New Coumarin-chalcone Scaffolds 
      Vázquez Rodríguez, Saleta; Guinez, Roberto; Matos, María; Olea Azar, Claudio; Maya Arango, Juan; Uriarte, Eugenio; Santana, Lourdes (Bentham Science, 2016)
      With the aim of finding new chemical entities based on coumarin and chalcone scaffolds, new hybrid compounds 2-5 were designed and synthesized. The trypanocidal activity of these compounds was tested against the epimastigote, ...
    • Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins 
      Matos, Maria João; Pérez Cruz, Fernanda; Vazquez Rodriguez, Saleta; Uriarte, Eugenio; Santana, Lourdes; Borges, Fernanda; Olea Azar, Claudio (Elsevier, 2013)
      In the present work we synthesized a series of hydroxy-3-arylcoumarins (compounds 1–9), some of them previously described as MAO-B selective inhibitors, with the aim of evaluating their antioxidant properties. Theoretical ...
    • Study of Coumarin-Resveratrol Hybrids as Potent Antioxidant Compounds 
      Matos, María; Mura Mardones, Francisco; Vázquez Rodríguez, Saleta; Borges, Fernanda; Santana, Lourdes; Uriarte, Eugenio; Olea Azar, Claudio (MDPI AG, 2015)
      In the present work we synthesized a selected series of hydroxylated 3-phenylcoumarins 5–8, with the aim of evaluating in detail their antioxidant properties. From an in depth study of the antioxidant capacity data ...
    • Synthesis and Electrochemical and Biological Studies of Novel Coumarin−Chalcone Hybrid Compounds 
      Pérez Cruz, Fernanda; Vazquez Rodriguez, Saleta; João Matos, Maria; Herrera Morales, Alejandra; Villamena, Frederick A.; Das, Amlan; Gopalakrishnan, Bhavani; Olea Azar, Claudio; Santana, Lourdes; Uriarte, Eugenio (American Chemical Society, 2013)
      A series of novel hydroxy-coumarin−chalcone hybrid compounds 2a−i has been synthesized by employing a simple and efficient methodology. An electrochemical characterization using cyclic voltammetry and ESR spectroscopy ...
    • Synthesis and study of the trypanocidal activity of catechol-containing 3-arylcoumarins, inclusion in ... 
      Pozo Martínez, Josué Santiago; Salgado Valdés, Francisco Javier; Liempi Manquel, Ana Isabel; Kemmerling Weis, Ulrike; Mera Adasme, Raúl; Olea Azar, Claudio Alberto; Moncada Basualto, Mauricio Javier; Borges, Fernanda; Uriarte, Eugenio; Matos, María Joao (Elsevier, 2022)
      American trypanosomiasis or Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and is considered a neglected disease, being an important problem for public health. Benznidazole (BZN) is the drug used to ...