Browsing by Subject "Cannabinoids"

Now showing items 1-2 of 2

    • New pyridone-based derivatives as cannabinoid receptor type 2 agonists 
      Faúndez Parraguez, Manuel; Alarcón Miranda, Carlos; Cho, Young Hwa; Pessoa Mahana, Hernan Armando; Gallardo Garrido, Carlos; Chung, Hery; Faúndez, Mario; Pessoa Mahana, David (MDPI, 2021)
      The activation of the human cannabinoid receptor type II (CB2R) is known to mediate analgesic and anti-inflammatory processes without the central adverse effects related to cannabinoid receptor type I (CB1R). In this work ...
    • Synthesis, binding assays, cytotoxic activity and docking studies of benzimidazole and benzothiophene ... 
      Romero Parra, Javier; Mella Ralpán, Jaime; Palmieri, Vittoria; Allara, Marco; Torres, María José; Pessoa Mahana, Hernán; Iturriaga-Vásquez, Patricio; Escobar, Rossy; Faúndez, Mario; Di Marzo, Vincenzo; Pessoa Mahana, Carlos David (Elsevier, 2016)
      Herein we report the design, synthesis, bioinformatic and biological studies of benzimidazole and benzothiophene derivatives as new cannabinoid receptor ligands. To test the hypothesis that the lack of a hydrogen bond ...