Browsing by Subject "LC3"

Now showing items 1-3 of 3

    • BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism 
      Rodríguez, Andrea E.; López Crisosto, Camila; Peña Oyarzún, Daniel; Salas, Daniela; Parra A., Valentina; Quiroga, Clara; Morawe, Tobías; Chiong Lay, Mario; Behl, Christian; Lavandero González, Sergio (Taylor and Francis, 2016)
      Autophagy is mainly regulated by post-translational and lipid modifications of ATG proteins. In some scenarios, the induction of autophagy is accompanied by increased levels of certain ATG mRNAs such as MAP1LC3B/LC3B, ATG5 ...
    • Regulation of total LC3 levels by angiotensin II in vascular smooth muscle cells 
      Mondaca Ruff, David Gonzalo; Quiroga, Clara; Norambuena Soto, Ignacio Estebán; Riquelme Meléndez, Jaime Andrés; San Martin, Alejandra; Bustamante Parraguez, Mario Andrés; Lavandero González, Sergio Alejandro; Chiong Lay, Mario Martín (Wiley, 2022)
      Hypertension is associated with high circulating angiotensin II (Ang II). We have reported that autophagy regulates Ang II-induced vascular smooth muscle cell (VSMC) hypertrophy, but the mechanism mediating this effect is ...
    • The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content 
      Shaikh, S.; Troncoso Cotal, Rodrigo; Mondaca Ruff, David; Parra Ortíz, María Valentina; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio (Elsevier, 2018)
      Stromal-interaction molecule 1 (STIM1)-mediated store-operated Ca2+ entry (SOCE) plays a key role in mediating cardiomyocyte hypertrophy, both in vitro and in vivo. Moreover, there is growing support for the contribution ...