Now showing items 1-5 of 5

    • Araya Maturana, Ramiro; Saitz Barría, Claudio; Pessoa Mahana, Hernán; Pessoa, D. (Bentham Science Publishers, 2003)
      The present review discusses the synthetic strategies of new ligands exhibiting mainly 5-HT1A binding affinities. Specifically we focused our attention in the synthesis of compounds structurally related to arylpiperazine, ...
    • Rojas, P. S.; Neira, D.; Muñoz, Mauricio; Lavandero González, Sergio; Fiedler Temer, Jenny (Wiley, 2014)
      Serotonin (5-HT) production and expression of 5-HT receptors (5-HTRs) occur early during prenatal development. Recent evidence suggests that, in addition to its classical role as a neurotransmitter, 5-HT regulates neuronal ...
    • Pessoa Mahana, Hernán; Kosche Cárcamo, Johann; Ron Higuera, Nadia; Recabarren Gajardo, Gonzalo; Saitz Barría, Claudio; Araya Maturana, Ramiro; Pessoa Mahana, Carlos (2008)
      A novel series of 2-benzothiophenealkylpiperazine derivatives 11 (a-d) with potential affinity at 5-HT1A serotonin receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene ...
    • Pessoa Mahana, Hernán; Araya Maturana, Ramiro; Saitz Barría, Claudio; Pessoa, D. (Bentham Science Publishers, Ltd, 2003)
      The present review discusses the synthetic strategies of new ligands exhibiting mainly 5-HT1A binding affinities. Specifically we focused our attention in the synthesis of compounds structurally telated to arylpiperazine, ...
    • Rojas Domínguez, Paulina; Fiedler Temer, Jenny (Frontiers Media, 2016)
      Serotonin (5-HT) is a neurotransmitter that plays an important role in neuronal plasticity. Variations in the levels of 5-HT at the synaptic cleft, expression or dysfunction of 5-HT receptors may alter brain development ...