Now showing items 601-620 of 2801

    • Nassif, Melissa; Valenzuela, Vicente; Rojas Rivera, Diego; Vidal, René; Matus, Soledad; Castillo, Karen; Fuentealba, Yerko; Kroemer, Guido; Levine, Beth; Hetz Flores, Claudio (Taylor and Francis Inc., 2014)
      Pharmacological activation of autophagy is becoming an attractive strategy to induce the selective degradation of aggregate-prone proteins. Recent evidence also suggests that autophagy impairment may underlie the pathogenesis ...
    • Jara, José A.; Castro Castillo, Vicente; Saavedra-Olavarría, Jorge; Peredo, Liliana; Pavanni, Mario; Jaña, Fabián; Letelier, María Eugenia; Parra, Eduardo; Becker, María Inés; Morello Casté, Antonio; Kemmerling Weis, Ulrike; Maya Arango, Juan; Ferreira, Jorge (American Chemical Society, 2014)
      Tumor cells principally exhibit increased mitochondrial transmembrane potential (Δψm) and altered metabolic pathways. The therapeutic targeting and delivery of anticancer drugs to the mitochondria might improve treatment ...
    • Morales, Pablo E.; Torres, Gloria; Sotomayor Flores, Cristian Alejandro; Peña Oyarzún, Daniel; Rivera Mejías, Pablo; Paredes, Felipe; Chiong Lay, Mario (Academic Press Inc., 2014)
      Incretin GLP-1 has important metabolic effects on several tissues, mainly through the regulation of glucose uptake and usage. One mechanism for increasing cell metabolism is modulating endoplasmic reticulum (ER)-mitochondria ...
    • Pardo Jiménez, Viviana Gladys; Barrientos, C.; Pérez Cruz, Karina Angélica; Navarrete Encina, Patricio; Olea Azar, Claudio; Núñez Vergara, Luis; Squella Serrano, Juan (2014)
      In this paper, a series of six dihydropyridine-fused coumarins were synthesized and electrochemically characterized in dimethylformamide (DMF). Dihydropyridine ring oxidation on glassy carbon electrode (GCE) for condensed ...
    • Parada, Mirtha; Valenzuela Barra, Gabriela; Delporte, Carla; Lara Peñaloza, Hernán (Universidad de Santiago de Chile, 2014)
      The estrous cycle disruptor effect of an ethanolic extract (EMATst) from Buddleja globosa leaves and standardized in its main component (verbascoside) was determined in rats after the subcutaneous administration of EMATst. ...
    • Hassan, Natalia; Oyarzún Ampuero, Felipe; Muñoz Lara, Pablo; Guerrero, Simón; Cabuil, Valérie; Abou-Hassan, Ali; Kogan Bocian, Marcelo (Bentham Science Publishers B.V., 2014)
      In this article we review the flow chemistry methodologies for the controlled synthesis of different kind of nano and microparticles for biomedical applications. Injection mechanism has emerged as new alternative for the ...
    • Ocaranza, Maria Paz; Moya, Jackeline; Barrientos, Victor; Alzamora, Rodrigo; Hevia, Daniel; Morales, Cristobal; Pinto, Melissa; Escudero, Nicolás; García Nannig, Lorena; Novoa, Ulises; Ayala, Pedro; Díaz Araya, Guillermo; Godoy, Ivan; Chiong Lay, Mario; Lavandero González, Sergio; Jalil Milad, Jorge (Lippincott Williams and Wilkins, 2014)
      BACKGROUND:: Little is known about the biological effects of angiotensin-(1-9), but available evidence shows that angiotensin-(1-9) has beneficial effects in preventing/ameliorating cardiovascular remodeling. OBJECTIVE:: ...
    • Acuña Rougier, C.; Jullian,; Olea Azar, Claudio (2012)
      Complexes formed by (±)-4′-hydroxyflavanone (OHFL) and the cyclodextrins β-cyclodextrin and (2-hydroxypropyl)-β-CD were obtained using the racemic mixture of the OHFL. These complexes were able to be studied due to their ...
    • Pedreschi, Franco; Bunger Timmermann, Andrea; Skurtys, Olivier; Allen, Paula; Rojas, Ximena (2012)
      Potato chips were classified in quality categories according to their color after frying at oil temperatures (120, 140, 160, and 180 ± 1 °C) and undergoing some pre-treatments (control or unblanching, blanching, and blanching ...
    • Gamboa, J.; Cornejo, L.; Acarapi, J.; Squella Serrano, Juan (Sociedad Chilena de Quimica, 2013)
      As (III) was determined by differential pulse polarography (DPP) in 1 mol L-1 HCl as supporting electrolyte. For quantification, the -0.35 V peak (versus Ag/AgCl) was chosen. The obtained detection and quantification limits ...
    • Mena, Juan F.; Neira Carrillo, Andrónico; Yazdani-Pedram Zobeiri, Mehrdad; Kogan Bocian, Marcelo (American Scientific Publishers, 2013)
      With the purpose of obtaining stable and non-toxic nanocomposites with potential biomedical applications we coated gold nanoparticles (AuNP) with chitosan (CHI) and CHI grafted with poly(Nisopropilacrylamide) (PNIPAAm) and ...
    • Pérez, M. De Los A.Arada; Yazdani-Pedram Zobeiri, Mehrdad (2013)
      ABSTRACT Chloride selective polymeric liquid membrane electrode has been developed by using Bis-(2-ethylhexyl) Sebacate (DOS) as plasticizer and 2-[5-(4-nitrophenyl) furyl]-4,5-diphenyl imidazole (FFDFIN) as ionophore. ...
    • Riveros, Ana; Dadlani, Komal; Salas, Edison; Caballero, Leonardo; Melo, Francisco; Kogan Bocian, Marcelo (American Scientific Publishers, 2013)
      There has been an increase in the research towards the use of nanoparticles as a promising tool for nanomedicine, from imagenology, drug and gene delivery, to phototherapy. Little is known regarding the interaction between ...
    • Folch Cano, Christian; Guerrero, Juan; Speisky Cosoy, Hernán; Jullian Matthaei, Carolina; Olea Azar, Claudio (2014)
      The present study is focused on the characterization of the interaction between (-)-epigallocatechingallate (EGCG) and cyclodextrins like β-cyclodextrin (βCD), heptakis(2,6 di-O-methyl)-β-cyclodextrin (DMβCD), and ...
    • Barreto, Antônio C.H.; Santiago, Vivian R.; Freire, Rafael M.; Mazzetto, Selma E.; Denardin, Juliano C.; Mele, Giuseppe; Cavalcante, Igor M.; Ribeiro, Maria E.N.P.; Ricardo, Nágila M.P.S.; Gonçalves, Tamara; Carbone, Luigi; Lemos, Telma L.G.; Pessoa, Otília D.L.; Fech (2013)
      This paper describes the investigation and development of a novel magnetic drug delivery nanosystem (labeled as MO-20) for cancer therapy. The drug employed was oncocalyxone A (onco A), which was isolated from Auxemma ...
    • Giordano, A.; Richter Duk, Pablo; Leiva, K.; Ascar, L. (Sociedad Chilena de Quimica, 2013)
      Silicone rod extraction (SR) is a siloxane-based methodology for the extraction of organic pollutants from aqueous samples with similar principle extraction as the stir bar sorptive extraction (SBSE). In this study the SR ...
    • Miranda, P.; Sepúlveda, A.; Morales, J.; Rodriguez, T.; Burgos, E.; Fernández, H. (2014)
      The stopping power of palladium for protons has been measured using the transmission method with an overall uncertainty of around 5% over the energy range Ep=(0.300-3.100) MeV. These stopping power data are then compared ...
    • Basualto, C.; Valenzuela, F. J.; Molina, L.; Munoz, J. P.; Fuentesand, E.; Sapag, J. (Sociedad Chilena de Quimica, 2013)
      In recent years there has been a great demand for rare earth metals because of their unique physical and chemical properties as new constituents for electronic, optical and magnetic devices. Because of their extremely ...
    • Jara Ulloa, Paola Andrea; Salgado Figueroa, Paola; Yañez,; Núñez Vergara, Luis; Squella Serrano, Juan (2012)
      We report the adsorptive voltammetric determination of nifedipine on multiwalled carbon nanotubes (MWCNT)-modified glassy carbon electrode (GCE). Nifedipine was adsorbed on the MWCNT and then reduced using linear sweep and ...
    • Garrido Reyes, Tatiana; Mendoza Crisosto, Jorge; Velásquez Vergara, Yaris (2013)
      O objetivo deste estudo foi utilizar a técnica de difusão em filmes finos por gradiente de concentração (DGT) para a avaliação da disponibilidade de cobre em solos com elevados níveis do metal, que foi alterado com ...