Browsing by Title Artículos de revistas

Now showing items 10257-10276 of 11553

    • Targeting hepatic glutaminase activity to ameliorate hyperglycemia 
      Miller, Russell A.; Shi, Yuji; Lu, Wenyun; Pirman, David A.; Jatkar, Aditi; Blatnik, Matthew; Wu, Hong; Cárdenas Matus, Julio; Wan, Min; Foskett, J. Kevin; Park, Junyoung O.; Zhang, Yiyi; Holland, William L.; Rabinowitz, Joshua D.; Birnbaum, Morris J. (Nature Publishing Group, 2018)
      Glucagon levels increase under homeostatic, fasting conditions, promoting the release of glucose from the liver by accelerating the breakdown of glycogen (also known as glycogenolysis). Glucagon also enhances gluconeogenic ...
    • Targeting HIV-1 integrase with aptamers selected against the purified RNase H domain of HIV-1 RT 
      Métifiot, Mathieu; León Decap, Oscar; Tarrago-Litvak, Laura; Litvak, Simon; Andréola, Marie-Line (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2005-10)
      Several in vitro strategies have been developed to selectively screen for nucleic acid sequences that bind to specific proteins. We previously used the SELEX procedure to search for aptamers against HIV-1 RNase H activity ...
    • Targeting innate immune cells for immunotherapy 
      Carreño, Leandro J.; Prados Rosales, Rafael; López, Mercedes; Baena, Andrés; González, Pablo A. (Hindawi Limited, 2017)
    • Targeting kupffer cells with antisense oligonucleotides 
      Ponnappa, Biddanda C.; Israel Jacard, Yedy (Frontiers in Bioscience, 2002)
      © 2002 Frontiers in Bioscience. All rights reserved.During proinflammatory reactions such as endotoxemia, ischemia-reperfusion and immune reactions, excessive amounts of cytokines and prostanoids are released resulting in ...
    • Targeting n-3 Polyunsaturated Fatty Acids in Non-alcoholic Fatty Liver Disease 
      Valenzuela, Rodrigo; Ortiz, Macarena; Hernández-Rodas, María Catalina; Echeverría, Francisca; Videla, Luis A. (Bentham Science, 2020)
      Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is characterized by abnormal hepatic accumulation of triacylglycerides in the absence of alcohol consumption, in association with Oxidative Stress (OS), a pro-inflammatory ...
    • Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of ... 
      Mercado, Gabriela; Castillo, Valentina; Soto, Paulina; López, Nélida; Axten, Jeffrey M.; Sardi, Sergio P.; Hoozemans, Jeroen J.M.; Hetz Flores, Claudio (Academic Press Inc., 2018)
      © 2018 Elsevier Inc. Parkinson's disease (PD) is the second most common neurodegenerative disorder, leading to the progressive decline of motor control due to the loss of dopaminergic neurons in the substantia nigra pars ...
    • Targeting resolvins in cholestatic liver injury 
      Videla, Luis A.; Valenzuela Baez, Rodrigo Wladimir (Ame Publ Co, 2021)
    • Targeting sphingosine-1-phosphate signaling in immune-mediated diseases: beyond multiple sclerosis 
      Pérez Jeldres, Tamara; Álvarez Lobos, Manuel; Rivera Nieves, Jesús (Adis, 2021)
      Sphingosine-1-phosphate (S1P) is a bioactive lipid metabolite that exerts its actions by engaging 5 G-protein-coupled receptors (S1PR1-S1PR5). S1P receptors are involved in several cellular and physiological events, ...
    • Targeting the Transient Receptor Potential Vanilloid Type 1 (TRPV1) Assembly Domain Attenuates Inflammation-induced ... 
      Flynn, Robyn; Chapman, Kevin; Iftinca, Mircea; Aboushousha, Reem; Varela Lekanda, Diego; Altier, Christophe (The American Society for Biochemistry and Molecular Biology, 2014)
      The transient receptor potential channel vanilloid type 1 (TRPV1) is a non-selective cation channel expressed in sensory neurons of the dorsal root and trigeminal ganglia. TRPV1 is a polymodal channel activated by noxious ...
    • Targeting the unfolded protein response for disease intervention 
      Rivas, Alexis; Vidal, René; Hetz Flores, Claudio (Taylor & Francis, 2015)
      Introduction: The accumulation of misfolded proteins in the endoplasmic reticulum (ER) generates a stress condition that engages the unfolded protein response (UPR). The UPR is an adaptive reaction that aims to reestablish ...
    • Targeting the unfolded protein response in disease 
      Hetz Flores, Claudio; Chevet, Eric; Harding, Heather P. (Macmillan, 2013)
      Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER) is a feature of specialized secretory cells and is also observed in many diseases, including cancer, diabetes, autoimmune conditions, ...
    • Targeting wistar rat as a model for studying benign, premalignant and malignant lesions of the prostate 
      Campolina Silva, Gabriel; Werneck Gomes, Hipacia; Bruna T., María; Barata, María C.; Torres, María José; Contreras Muñoz, Héctor; Mahecha, Germana; Oliveira, Cleida (Elsevier, 2020)
      Aims: The purpose of this study was to describe a suitable experimental model for studying aging-related prostate disorders including cancer. Materials and methods: 12-month old Wistar rats were kept in control conditions ...
    • Task-related gamma-band dynamics from an intracerebral perspective: Review and implications for surface EEG and MEG 
      Jerbi, Karim; Ossandón, Tomás; Hamamé, Carlos M.; Senova, S.; Dalal, Sarang S.; Jung, Julien; Minotti, Lorella; Bertrand, Olivier; Berthoz, Alain; Kahane, Philippe; Lachaux, Jean Philippe (2009)
      Although non-invasive techniques provide functional activation maps at ever-growing spatiotemporal precision, invasive recordings offer a unique opportunity for direct investigations of the fine-scale properties of neural ...
    • Taste thresholds for phenylthiourea among Chileans 
      Saldanha, P. H.; Nacrur, J. (1963)
    • Tau oligomers and fibrils induce activation of microglial cells 
      Morales, Inelia; Jiménez, José M.; Mancilla, Marcela; Maccioni Baraona, Ricardo (IOS Press, 2013)
      Neuroinflammation is a process related to the onset of several neurodegenerative disorders, including Alzheimer's disease (AD). Increasing sets of evidence support the major role of deregulation of the interaction patterns ...
    • Tau platelets correlate with regional brain atrophy in patients with Alzheimer's disease 
      Slachevsky Chonchol, Andrea; Guzman Martínez, Leonardo; Delgado Derio, Carolina; Reyes Sánchez, Pablo; Farías Gontupil, Gonzalo; Muñoz Neira, Carlos; Bravo, Eduardo; Farías, Mauricio; Flores Rodríguez, Patricia; Garrido Inostroza, Cristian; Becker, James; López, Oscar; Maccioni Baraona, Ricardo (IOS Press, 2017)
      Background: Intracellular neurofibrillary tangles are part of the core pathology of Alzheimer's disease (AD), which are mainly composed of hyperphosphorylated tau protein. Objectives: The purpose of this study is to ...
    • Teaching experience in Psychiatric Consultant-laison in Primary Care Settings Experiencia Docente en ... 
      Acuña, Julia; Roizblatt Scherzer, Arturo; Fullerton, Claudio; Botto Valle, Alberto (2007)
      Authors describe an initial program for training residents as consultants in Primary Care Settings. This program was developed and applied by the Department of Psychiatry and Mental Health of the Faculty of Medicine of the ...
    • Teaching neurology to undergraduates: A proposal Enseñanza de la neurología en el pregrado: Propuesta de ... 
      Eurolo, Juan; Álvarez, Gonzalo (2004)
      According to the authors neurology in this country is perceived as difficult and intractable, by non-neurologists. This distant attitude is observable in other countries as well. The teaching of neurology to undergraduates ...
    • Teaching of clinical reasoning to medical students using prototypical clinical cases Aprendizaje del ... 
      Montaldo Lorca, Gustavo; Herskovic L, Pedro (2013)
      Background: Clinical reasoning is the most important competence in the training process of a physician. Aim: To develop a method for teaching clinical reasoning based on prototypes of clinical cases. Material and Methods: ...
    • Teaching of psychiatry for undergraduates Sobre la enseñanza psiquiátrica de pre-grado. 
      Davanzo, (1992)
      This paper postulates that Psychiatry does not fit in the group of the so called medical specialties. It should rather be recognized as a 5th basic clinical discipline if the graduating general practitioner is to cope ...