Browsing by Author "Maccioni Baraona, Ricardo"

Now showing items 21-33 of 33

    • Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease 
      Rojo, Leonel E.; Sjoberg, Marcela; Hernández, Paula; Zambrano, Cristian; Maccioni Baraona, Ricardo (HINDAWI PUBLISHING CORPORATION, 2006)
      Alzheimer's disease is the principal cause of dementia throughout the world and the fourth cause of death in developed economies. This brain disorder is characterized by the formation of brain protein aggregates, namely, ...
    • Shilajit: A natural phytocomplex with potential procognitive activity 
      Carrasco Gallardo, Carlos; Guzmán, Leonardo; Maccioni Baraona, Ricardo (2012)
      Shilajit is a natural substance found mainly in the Himalayas, formed for centuries by the gradual decomposition of certain plants by the action of microorganisms. It is a potent and very safe dietary supplement, restoring ...
    • Specific macromolecular interactions between tau and the microtubule system 
      Farías, Gustavo A.; Vial, Clarisa; Maccioni Baraona, Ricardo (Kluwer Academic Publishers, 1992)
      The microtubule-associated protein Tau, a major component of brain microtubules, shares common repeated C-terminal sequences with the high molecular-weight protein MAP-2. It has been shown that tau peptides V187-G204 and ...
    • Subpopulations of tau interact with microtubules and actin filaments in various cell types 
      Henríquez, Juan P.; Cross, Daniel; Vial, Clarisa; Maccioni Baraona, Ricardo (1995)
      It has been demonstrated that microtubule‐associated proteins (MAPs) interact with tubulin in vitro and in vivo. However, there is no clear evidence on the possible roles of the interactions of MAPs in vivo with other ...
    • Tau oligomers and fibrils induce activation of microglial cells 
      Morales, Inelia; Jiménez, José M.; Mancilla, Marcela; Maccioni Baraona, Ricardo (IOS Press, 2013)
      Neuroinflammation is a process related to the onset of several neurodegenerative disorders, including Alzheimer's disease (AD). Increasing sets of evidence support the major role of deregulation of the interaction patterns ...
    • The antineoplasic agent estramustine and the derivative estramustine-phosphate inhibit secretion of ... 
      Martínez, Jorge; Santibáñez, Juan Francisco; Vial, Clarisa; Maccioni Baraona, Ricardo (Kluwer Academic Publishers, 1992)
      The antineoplasic drug estramustine is an adduct of estradiol and nor-nitrogen mustard. It has been shown that this drug interferes with microtubule assembly, an effect mediated by estramustine interaction with ...
    • The association of tau-like proteins with vimentin filaments in cultured cells 
      Capote, Carolina; Maccioni Baraona, Ricardo (Academic Press Inc., 1998)
      There is increasing evidence that the different polymers that constitute the cytoskeleton are interconnected to form a three-dimensional network. The macromolecular interaction patterns that stabilize this network and its ...
    • The compound 14-keto stypodiol diacetate from the algae Stypopodium flabelliforme inhibits microtubules and ... 
      Depix, María S.; Martínez, Jorge; Santibañez, Francisco; Rovirosa, Juana; San Martín Barrientos, Aurelio; Maccioni Baraona, Ricardo (1998)
      We investigated the effects of the drug 14-keto-stypodiol diacetate (SDA) extracted from the seaweed product Stypopodium flabelliforme, in inhibiting the cell growth and tumor invasive behavior of DU-145 human prostate ...
    • The damage signals hypothesis of Alzheimer's disease pathogenesis 
      Fernández, Jorge A.; Rojo, Leonel; Kuljis, Rodrigo O.; Maccioni Baraona, Ricardo (IOS Press, 2008)
      Virtually none of the hypotheses on Alzheimer's disease (AD) pathogenesis address the earliest events that trigger the molecular alterations that precede cerebral degeneration and account for the diversity of risk factors ...
    • The Revitalized Tau Hypothesis on Alzheimer's Disease 
      Maccioni Baraona, Ricardo; Farías, Gonzalo; Morales, Inelia; Navarrete, Leonardo (2010)
      Many hypotheses have been raised regarding the pathophysiology of Alzheimer's disease (AD). Because amyloid beta peptide (Aβ) deposition in senile plaques appears as a late, nonspecific event, recent evidence points to tau ...
    • The secretion of urokinase‐like plasminogen activator is inhibited by microtubule‐interacting drugs 
      Santibañez, Juan F.; Maccioni Baraona, Ricardo; Martínez, Jorge (1995)
      The secretion of proteinases into the extracellular matrix is one of the main features of tumour cells, as related to their invasive behaviour. Considering the role of the microtubule cytoskeleton, and particularly the ...
    • Tubulin domains for the interaction of microtubule associated protein DMAP-85 from Drosophila melanogaster 
      Henríquez, Juan P.; Cambiazo Ayala, Verónica; Maccioni Baraona, Ricardo (1996)
      The interaction of microtubule associated proteins (MAPs) with the microtubule system has been characterized in depth in neuronal cells from various mammalian species. These proteins interact with well-defined domains ...
    • Tubulin, actin, and tau protein interactions and the study of their macromolecular assemblies 
      Farías, Gustavo A.; Muñoz, Juan P.; Garrido, Jorge; Maccioni Baraona, Ricardo (2002)
      The intracellular polymerization of cytoskeletal proteins into their supramolecular assemblies raises many questions regarding the regulatory patterns that control this process. Binding experiments using the ELISA solid ...