Browsing by Subject "Dopamine"
Now showing items 21-40 of 41
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DT-diaphorase protects against autophagy induced by aminochrome dependent alpha synuclein oligomers (Springer, 2017)Alpha-synuclein (SNCA) oligomers have been reported to inhibit autophagy. Aminochrome-induced SNCA oligomers are neurotoxic, but the flavoenzyme DT-diaphorase prevents both their formation and their neurotoxicity. However, ...
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(Elsevier, 2016)Astrocytes are exposed to aminochrome via the oxidation of dopamine that is taken up from the synaptic cleft after its release from dopaminergic neurons. Glutathione transferase M2-2 (GSTM2) has been shown to protect ...
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(1981)The interaction of dopamine and angiotensln II (AH) on blood pressure and heart rate was studied in rats. The influence of reserpine pretreatment and ragotomy was also studied. Inbred rats anesthetized with urethane received ...
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(Taylor and Francis Inc., 2014)U373MG cells constitutively express glutathione S-transferase mu 2 (GSTM2) and exhibit 3H-dopamine uptake, which is inhibited by 2 μM of nomifensine and 15 μM of estradiol. We generated a stable cell line (U373MGsiGST6) ...
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(1983)The influence of luteinizing hormone releasing hormone (LHRH) on the behavioral effects induced by several doses of D-amphetamine (0.25, 0.5, 1.0 and 2.0 mg/kg IP) was studied. A dose response relation was previously ...
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(2002)Intracerebral manganese administration together with the DT-diaphorase inhibitor dicoumarol (Mn3+ 40 nmol+-dicoumarol 2 nmol; in 4 μl) into the left medial forebrain bundle (MFB) produced a behavioural pattern characterised ...
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(Elsevier, 2017)There are several interrelated mechanisms involving iron, dopamine, and neuromelanin in neurons. Neuromelanin accumulates during aging and is the catecholamine-derived pigment of the dopamine neurons of the substantia ...
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(Springer New York LLC, 2018)© 2018, Springer Science+Business Media, LLC, part of Springer Nature.Translational medicine is one of the major concerns in this century. While significant advances have been made with scientific knowledge, the translation ...
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(2003)Asphyxia during birth can cause gross brain damage, but also subtle perturbations expressed as biochemical or motor deficits with late onset in life. Thus, it has been shown that brain dopamine levels can be increased or ...
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Novel Alpha-Synuclein Oligomers Formed with the Aminochrome-Glutathione Conjugate Are Not Neurotoxic (Springer New York LLC, 2019)© 2018, Springer Science+Business Media, LLC, part of Springer Nature.Aminochrome induces neurotoxic alpha-synuclein oligomer formation relevant to the etiology of Parkinson’s disease. Oxidative stress produces aminochrome ...
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(Amer Physiological Soc, 2015)In a rest period immediately after a task, neurons in the hippocampus, neocortex, and striatum exhibit spatiotemporal correlation patterns resembling those observed during the task. This reactivation has been proposed as ...
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(Springer, 2017)Dopamine oxidation in the pathway leading to neuromelanin formation generates the ortho-quinone aminochrome, which is potentially neurotoxic but normally rapidly converted by DT-diaphorase to nontoxic leukoaminochrome. ...
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(Medknow Publications & Media Pvt, 2017)For 50 years ago was introduced L-3,4-dihydroxyphenylalanine (L-dopa) in Parkinson's disease treatment and during this significant advances has been done but what trigger the degeneration of the nigrostriatal system remain ...
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One-electron reduction of 6-hydroxydopamine quinone is essential in 6-hydroxydopamine neurotoxicity (2013)6-Hydroxydamine has widely been used as neurotoxin in preclinical studies related on the neurodegenerative process of dopaminergic neurons in Parkinson's disease based on its ability to be neurotoxic as a consequence of ...
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(2012)We tested the hypothesis that both VMAT-2 and DT-diaphorase are an important cellular defense against aminochrome-dependent neurotoxicity during dopamine oxidation. A cell line with VMAT-2 and DT-diaphorase over-expressed ...
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(1998)We studied the effects of the nitric oxide (NO) synthase inhibitor, Nω- nitro-L-arginine methyl ester (L-NAME), and the NO donor, sodium nitroprusside (SNP) on cat chemosensory responses to intravenous injections of NaCN ...
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(Elsevier, 1983)The influence of both reserpine-induced depletion of catecolamines and chlorpromazine-induced blockade of dopamine receptors on integrative properties of rats prefrontal pyramidal cells was studied by evocating threshold ...
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(Springer, 2020)Flavonoids have been suggested to protect dopaminergic neurons in Parkinson’s disease based on studies that used exogenous neurotoxins. In this study, we tested the protective ability of agathisflavone in SH-SY5Y cells ...
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(American Chemical Society, 2017)Aminochrome, an orthoquinone formed during the dopamine oxidation of neuromelanin, is neurotoxic because it induces mitochondria dysfunction, protein degradation dysfunction (both autophagy and proteasomal systems), ...