Now showing items 6108-6127 of 11551

    • Casas, Mariana; Figueroa, Reinaldo; Jorquera, Gonzalo; Escobar, Matías; Molgó, Jordi; Jaimovich Pérez, Enrique (2010)
      Tetanic electrical stimulation induces two separate calcium signals in rat skeletal myotubes, a fast one, dependent on Cav 1.1 or dihydropyridine receptors (DHPRs) and ryanodine receptors and related to contraction, and a ...
    • Trautmann, Agnes; Vivarelli, Marina; Samuel, Susan; Gipson, Debbie; Sinha, Aditi; Schaefer, Franz; Hui, Ng Kar; Boyer, Olivia; Saleem, Moin A.; Feltran, Luciana; Müller-Deile, Janina; Becker, Jan Ulrich; Cano Schuffeneger, Francisco; Xu, Hong; Lim, Yam Ngo; Smoyer, William; Anochie, Ifeoma; Nakanishi, Koichi; Hodson, Elisabeth; Haffner, Dieter (Springer, 2020)
      Idiopathic nephrotic syndrome newly affects 1-3 per 100,000 children per year. Approximately 85% of cases show complete remission of proteinuria following glucocorticoid treatment. Patients who do not achieve complete ...
    • Urra, Hery; Henríquez, Daniel R.; Cánovas, José; Villarroel Campos, David; Carreras Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Álvarez Rojas, Sebastián; Figueroa, Ricardo; Vidal, René L.; Rodríguez, Diego A.; Rivera, Claudia A.; Court, Felipe A.; Couve Correa, Andrés; Qi, Ling; Chevet, Eric; Akai, Ryoko; Iwawaki, Takao; Concha, Miguel L.; Glavic Maurer, Álvaro; González Billault, Christian; Hetz Flores, Claudio (Nature, 2018)
      Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer ...
    • Durán Aniotz, Claudia; Cornejo, Victor Hugo; Espinoza, Sandra; Ardiles, Alvaro O.; Medinas Bilches, Danilo; Salazar, Claudia; Foley, Andrew; Gajardo, Ivana; Thielen, Peter; Iwawaki, Takao; Scheper, Wiep; Soto, Claudio; Palacios, Adrian G.; Hoozemans, Jeroen J. M.; Hetz Flores, Claudio (Springer, 2017)
      Altered proteostasis is a salient feature of Alzheimer's disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress and abnormal protein aggregation. ER stress triggers the activation of the unfolded ...
    • Paya González, Ernesto (Soc Chilena Infectología, 2016)
    • Ruz, Manuel; Carrasco, Fernando; Arenas Rojas, Pamela; Codoceo, Juana; Inostroza, Jorge; Rebolledo, Annabella; Basfi-fer Obregón, Karen; Csendes Juhasz, Attila; Papapietro Vallejo, Karin; Pizarro Aguirre, Fernando; Olivares, Manuel; Sian, Lei; Westcott, Jamie L.; Hambidge, K. Michael; Krebs, Nancy F. (2009)
      Background: Iron deficiency and iron deficiency anemia are common in patients who undergo gastric bypass. The magnitude of change in iron absorption is not well known. Objective: The objective was to evaluate the effects ...
    • Hertrampf,; Olivares,; Pizarro Pizarro, Daniel Iván (1980)
    • Aguirre, Pabla; Mena, Natalia P.; Carrasco, Carlos M.; Muñoz, Yorka; Pérez Henríquez, Patricio; Morales, Rodrigo A.; Cassels Niven, Bruce; Méndez Gálvez, Carolina; García Beltrán, Olimpo; González Billault, Christian; Núñez González, Marco (Public Library of Science, 2015)
      © 2015 Aguirre et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in anymedium, provided the original ...
    • Serrano, Carolina; Villagr án, Andrea; Toledo Araya, Héctor; Crabtree, Jean; Harris, Paul (Wiley, 2016)
      Helicobacter pylori infection has been associated with an imbalance of iron homeostasis. IL-1b has been related with iron absorption disturbances through a variety of mechanisms. The aim of this study was to evaluate ...
    • Serrano, Carolina A.; Villagrán, Andrea; Toledo, Héctor; Crabtree, Jean E.; Harris, Paul R. (Blackwell Publishing Ltd, 2016)
      © 2016 John Wiley & Sons Ltd.Background: Helicobacter pylori infection has been associated with an imbalance of iron homeostasis. IL-1β has been related with iron absorption disturbances through a variety of mechanisms. ...
    • Peirano, Patricio D.; Algarín, Cecilia R.; Garrido, Marcelo I.; Lozoff, Betsy (2007)
      The highest prevalence of iron deficiency anemia (IDA) in infancy coincides with a time of rapid changes in sleep organization. Since IDA in infancy is associated with long-lasting neurofunctional effects despite iron ...
    • Muñoz, Pablo; Humeres, Alexis (2012)
      Because of the intrinsic ability of iron to catalyze the formation of reactive oxygen species, it has been associated with oxidative stress and neurodegenerative diseases. However, iron deficiency (ID) also negatively ...
    • Osorio, Héctor; Martínez, Verónica; Veloso, Felipe A.; Pedroso, Inti; Valdés, Jorge; Jedlicki Corbeaux, Eugenia; Holmes, David S.; Quatrini, Raquel (Elsevier B.V., 2008-11)
      An understanding of the physiology and metabolic complexity of microbial consortia involved in metal solubilization is a prerequisite for the rational improvement of bioleaching technologies. Among the most challenging ...
    • Muñoz, Pablo; Humeres, Alexis; Elgueta, Claudio; Kirkwood, Alfredo; Hidalgo Tapia, María Cecilia; Núñez González, Marco (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2011-04-15)
      Iron deficiency hinders hippocampus-dependent learning processes and impairs cognitive performance, but current knowledge on the molecular mechanisms underlying the unique role of iron in neuronal function is sparse. Here, ...
    • Gómez, Francisco J.; Aguirre, Pabla; González Billault, Christian; Núñez González, Marco (2011)
      Studies in post-mortem tissues of patients with Parkinson's disease (PD) and in mice treated with 6-hydroxydopamine have shown a decrease in the length of axon and dendrites of striatal neurons. However, the etiology of ...
    • Hertrampf,; Olivares,; Letelier, Carolina; Castillo, Andrea (1994)
      The frequency of anemia and iron nutrition deficiency was assessed in 342 low socioeconomic level pregnant teenagers at entry to prenatal care in 5 outpatient clinics from a South Orient area of Santiago Chile. According ...
    • Alvarado Díaz, Carlos Patricio; Núñez González, Marco; Devoto, Luigi; González Ramos, Reinaldo (Elsevier, 2015)
      Objective: To evaluate the effect of iron overload on nuclear factor kappa-B (NF-kappa B) activation in human endometrial stromal cells (ESCs). Design: Experimental study. Setting: University hospital research ...
    • Walter, Tomás; Olivares, Manuel; Pizarro Aguirre, Fernando; Muñoz, Carlos (1997)
      The data on the relationship between iron deficiency and infection are conflicting. Some researchers conclude that mild iron deficiency is beneficial for immunity, whereas others contend that any deficit is not good for ...
    • Espinoza, Alejandra; Le Blanc, Solange; Olivares, Manuel; Pizarro Aguirre, Fernando; Ruz, Manuel; Arredondo, Miguel (2012)
      Iron (Fe), copper (Cu), and zinc (Zn) fulfill various essential biological functions and are vital for all living organisms. They play important roles in oxygen transport, cell growth and differentiation, neurotransmitter ...
    • Hertrampf,; Olivares,; Amoros, Walter; Pizarro Pizarro, Daniel Iván; Heresi,; Llaguno,; Vega,; Cayazzo,; Chadud, (1990)
      We evaluated the effect of iron-supplemented milk on 86 healthy infants who were followed from 3 to 12 months of age. Whole milk was supplemented with 15 mg elementary iron as ferrous sulphate and 100 mg ascorbic acid per ...