Browsing by Author "Kalergis, Alexis M."

Now showing items 1-10 of 10

    • Aldosterone Promotes Autoimmune Damage by Enhancing Th17-Mediated Immunity 
      Herrada, Andrés A.; Contreras, Francisco J.; Marini, Natacha P.; Amador, Cristian A.; González, Pablo A.; Cortés, Claudia M.; Riedel, Claudia A.; Carvajal, Cristián A.; Figueroa, Fernando; Michea Acevedo, Luis; Fardella, Carlos E.; Kalergis, Alexis M. (American Association of Immunologists, 2010)
      Excessive production of aldosterone leads to the development of hypertension and cardiovascular disease by generating an inflammatory state that can be promoted by T cell immunity. Because nature and intensity of T cell ...
    • Allergens of the urushiol family promote mitochondrial dysfunction by inhibiting the electron transport at ... 
      Pacheco, Rodrigo; Quezada, Sergio A.; Kalergis, Alexis M.; Becker, María Inés; Ferreira, Jorge; Ioannes, Alfredo E. de (Sociedad de Biología de Chile, 2021)
      Background: Urushiols are pro-electrophilic haptens that cause severe contact dermatitis mediated by CD8+ efector T-cells and downregulated by CD4+ T-cells. However, the molecular mechanism by which urushiols stimulate innate ...
    • B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcγRIIb, ... 
      Catalán Martina, Diego; Aravena, Octavio; Sabugo, Francisca; Wurmann, Pamela; Soto, Lilian; Kalergis, Alexis M.; Cuchacovich Turteltaub, Miguel; Aguillón Gutiérrez, Juan Carlos (2010)
      Introduction: Several molecules help preserve peripheral B cell tolerance, but when altered, they may predispose to autoimmunity. This work studied the expression of the costimulatory molecule CD86 and the inhibitory ...
    • The capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells ... 
      Bueno, Susan; González, Pablo A.; Carreño Márquez, Leandro; Tobar, Jaime A.; Mora, Guido C.; Pereda, Cristián; Salazar Onfray, Flavio; Kalergis, Alexis M. (BLACKWELL, 2008-08)
      Infection with Salmonella enterica serovar Typhimurium (S. Typhimurium) causes a severe and lethal systemic disease in mice, characterized by poor activation of the adaptive immune response against Salmonella-derived ...
    • Characterization of the anti-inflammatory capacity of IL-10-producing neutrophils in response to Streptococcus ... 
      González, Liliana A.; Melo González, Felipe; Sebastián, Valentina P.; Vallejos, Omar P.; Noguera, Loreani P.; Suazo, Isidora D.; Schultz Lombardic, Barbara Melinka; Manosalva, Andrés H.; Peñaloza, Hernán F.; Soto, Jorge A.; Parker, Dane; Riedel, Claudia A.; González, Pablo A.; Kalergis, Alexis M.; Bueno, Susan M. (Frontiers Media, 2021)
      Neutrophils are immune cells classically defined as pro-inflammatory effector cells. However, current accumulated evidence indicates that neutrophils have more versatile immune-modulating properties. During acute lung ...
    • Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by ... 
      Arriagada, Alejandro A.; Albornoz, Eduardo; Opazo, María Cecilia; Becerra, Álvaro; Vidal, Gonzalo; Fardella, Carlos; Michea Acevedo, Luis; Carrasco, Nancy; Simón, Felipe; Elorza, Álvaro A.; Bueno, Susan M.; Kalergis, Alexis M.; Riedel, Claudia A. (Endocrine Society, 2015)
      Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated ...
    • Maternal Hypothyroxinemia impairs Spatial Learning and Synaptic nature and function in the Offspring 
      Opazo, M. C.; Gianini, A.; Pancetti, F.; Azkcona, G.; Alarcón, L.; Lizana, R.; Noches, V.; Gonzalez, P. A.; Porto, M.; Mora Gutiérrez, Sergio; Rosenthal, D.; Eugenin, E.; Naranjo, D.; Kalergis, Alexis M.; Riedel, Claudia A. (Endocrine Society, 2008-10)
      Neurological deficits in the offspring caused by human maternal hypothyroxinemia are thought to be irreversible. To understand the mechanism responsible for these neurological alterations, we induced maternal hypothyroxinemia ...
    • Modulation of endosome function, vesicle trafficking and autophagy by human herpesviruses 
      Tognarelli, Eduardo; Reyes, Antonia; Corrales, Nicolás; Carreño Marquez, Leandro Javier; Bueno, Susan; Kalergis, Alexis M.; González, Pablo A. (MDPI, 2021)
      Human herpesviruses are a ubiquitous family of viruses that infect individuals of all ages and are present at a high prevalence worldwide. Herpesviruses are responsible for a broad spectrum of diseases, ranging from skin ...
    • Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases 
      Mackern-Oberti, Juan Pablo; Llanos, Carolina; Vega, Fabián; Salazar Onfray, Flavio; Riedel, Claudia A.; Bueno, Susan M.; Kalergis, Alexis M. (Elsevier, 2015)
      Dendritic cells (DCs) play a key role in the activation of the immune response against pathogens, as well as in the modulation of peripheral tolerance to self-antigens (Ags). Furthermore, an imbalance in the activating/inhibitory ...
    • Short-term lipopolysaccharide stimulation indeces differentiation of murine bone marrow-derived dentritic ... 
      Salazar, Lorena; Aravena, Octavio; Contreras Levicoy, Juan; Pesce Reyes, Bárbara; Catalán Martina, Diego; Zúñiga, Roberto; Iruretagoyena, Mirentxu; Kalergis, Alexis M.; Aguillón Gutiérrez, Juan Carlos (2007)
      Dendritic cells (DCs) are professional, antigen-presenting cells, which induce and regulate T cell reactivity. DCs are crucial in innate and adaptive immune responses, and are also involved in central and peripheral tolerance ...