Browsing by Author "Maccioni Baraona, Ricardo"
Now showing items 1-20 of 33
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Vial, Clarisa; Armas Portela, Rosario; Avila, Jesús; González, Mauricio; Maccioni Baraona, Ricardo (Kluwer Academic Publishers, 1995)Microtubule-associated proteins (MAPs) interact with tubulin in vitro and in vivo. Despite that there is a large amount of information on the roles of these proteins in neurons, the data on non-neuronal MAPs or MAPs-related ...
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Moraga, Daniel M.; Nuñez, Patricio; Garrido, Jorge; Maccioni Baraona, Ricardo (1993)Abstract: Much indirect evidence suggests that the interconnections of actin microfilaments with the microtubule system are mediated by microtubule‐associated proteins (MAPs). In this study we provide new data to support ...
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Núñez Millacura, Claudia; Tapia, Victoria; Muñoz, Patricia; Maccioni Baraona, Ricardo; Núñez González, Marco (2002)Intracellular reactive iron is a source of free radicals and a possible cause of cell damage. In this study, we analyzed the changes in iron homeostasis generated by iron accumulation in neuroblastoma (N2A) cells and ...
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Maccioni Baraona, Ricardo; Lavados Montes, Manuel; Guillón, Marta; Mujica, Cristina; Bosch, Rubén; Farías, Gustavo; Fuentes, Patricio (2006)Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence of extracellular amyloid deposits, consisting largely of Aβ peptide and the presence of intraneuronal aggregates of neurofibillary ...
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Sáez, Estefanía T.; Pehar, Mariana; Vargas, Marcelo; Barbeito, Luis; Maccioni Baraona, Ricardo (2004)Production of nitric oxide (NO) by glial cells has been proposed to mediate cytotoxic effects on neighboring neurons. Although extensive genetic data implicate the beta amyloid peptide (Aβ) in the neurodegenerative cascade ...
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Mendoza Naranjo, Ariadna; González Billault, Christian; Maccioni Baraona, Ricardo (2007)A number of psychiatric and neurodegenerative disorders, such as Alzheimer's disease, are characterized by abnormalities in the neuronal cytoskeleton. Here, we find that the enhancement in actin polymerization induced by ...
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Carrasco-Gallardo, Carlos; Farías, Gonzalo A.; Fuentes, Patricio; Crespo, Fernando; Maccioni Baraona, Ricardo (2012)Alzheimer's disease (AD) is a brain disorder displaying a prevalence and impact in constant expansion. This expansive and epidemic behavior is concerning medical and public opinion while focusing efforts on its prevention ...
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Cross, Daniel; Farías, Gustavo; Domínguez, Jorge; Avila, Jesús; Maccioni Baraona, Ricardo (Kluwer Academic Publishers, 1994)After the finding of the involvement of the C-terminal moieties of tubulin subunits in the interaction of MAPs, different studies have focused on the substructure of the binding domains for the different MAPs. Current ...
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Muñoz, Juan P.; Huichalaf, Claudia H.; Orellana, Daniel; Maccioni Baraona, Ricardo (2007)The cdk5/p35 complex has been implicated in a variety of functions related to brain development, including axonal outgrown and neuronal migration. In this study, by co-immunoprecipitation and pull-down experiments, we have ...
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Cognitive impairment and Alzheimer's disease: Links with oxidative stress and cholesterol metabolism Sekler, Maria Alejandra; Jiménez, José M.; Rojo, Leonel; Pastene, Edgard; Fuentes, Patricio; Slachevsky Chonchol, Andrea; Maccioni Baraona, Ricardo (2008)Oxidative stress has been implicated in the progression of a number of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease and amyotrophic lateral sclerosis. We carried out an in-depth study ...
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Cambiazo Ayala, Verónica; González, Mauricio; Maccioni Baraona, Ricardo (1995)Abstract: Microtubule‐associated proteins (MAPs) play major regulatory roles in the organization and integrity of the cytoskeletal network. Our main interest in this study was the identification and the analysis of structural ...
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Guzmán Martínez, Leonardo; Farías, Gonzalo A.; Maccioni Baraona, Ricardo (2012)Alzheimer's disease (AD) diagnosis still depends on the triad of clinical, imaging and neuropsychological testing. The development of accurate, easy to use and inexpensive biological markers for AD is a long-standing ...
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Morales, Inelia; Guzmán Martínez, Leonardo; Cerda Troncoso, Cristóbal; Farías, Gonzalo A.; Maccioni Baraona, Ricardo (Frontiers Research Foundation, 2014)Alzheimer disease (AD) is the most common cause of dementia in people over 60 years old. The molecular and cellular alterations that trigger this disease are still diffuse, one of the reasons for the delay in finding an ...
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Neuroinflammation: Implications for the Pathogenesis and Molecular Diagnosis of Alzheimer's Disease Rojo, Leonel E.; Fernández, Jorge A.; Maccioni, Andrea A.; Jiménez, José M.; Maccioni Baraona, Ricardo (2008)During the past few years, an increasing set of evidence has supported the major role of deregulation of the interaction patterns between glial cells and neurons in the pathway toward neuronal degeneration. Neurons and ...
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Maccioni Baraona, Ricardo (2002)
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Maccioni Baraona, Ricardo; Tapia, José Pablo; Guzmán Martínez, Leonardo (Elsevier Inc., 2018)
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Sáez, Estefanía T.; Pehar, Mariana; Vargas, Marcelo R.; Barbeito, Luis; Maccioni Baraona, Ricardo (2006)Reactive astrocytes surround amyloid depositions and degenerating neurons in Alzheimer's disease (AD). It has been previously shown that β-amyloid peptide induces inflammatory-like responses in astrocytes, leading to ...
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Guzmán, Leda; Bustos, Rodrigo; Maccioni Baraona, Ricardo (Kluwer Academic Publishers, 1994)The changes in the levels of microtubule-associated proteins (MAPs) during advanced embryonic stages, neonatal and adult organisms reflect the importance of these cytoskeletal proteins in relation to the morphogenesis of ...
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Muñoz, Juan P.; Sánchez, Jaime R.; Maccioni Baraona, Ricardo (2003)Neuronal differentiation implies morphological and biochemical changes to generate a specialized neuron. N2A neuroblastoma cells can be promoted to undergo differentiation associated to neurites outgrowth, a process linked ...
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Orellana, Daniel I.; Quintanilla, Rodrigo A.; González Billault, Christian; Maccioni Baraona, Ricardo (Springer New York LLC, 2005)Recent studies show that inflammation has an active role in the onset of neurodegenerative diseases. It is known that in response to extracellular insults microglia and/or astrocytes produce inflammatory agents. These ...