Browsing by Author "Quest, Andrew F. G."

Now showing items 1-20 of 47

    • A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion 
      Díaz, Jorge; Mendoza, Pablo; Silva, Patricio; Quest, Andrew F. G.; Torres, Vicente A. (Landes Bioscience, 2014)
      © Jorge Díaz, Pablo endoza, Patricio Silva, Andrew FG Quest, and Vicente A Torres. The small GTPase Rab5 has been frequently studied in the context of intracellular trafficking, but evidence obtained more recently has ...
    • Age-dependent increases in apoptosis/necrosis ratios in human lymphocytes exposed to oxidative stress 
      Behrens Pellegrino, María Isabel; Silva, Monica; Schmied, Astrid; Salech Morales, Felipe; Manzur, Hachi; Rebolledo, Rolando; Bull Simpfendorfer, Ricardo; Torres, Vicente; Henríquez, Mauricio; Quest, Andrew F. G. (2011)
      Unlike apoptosis, mechanisms leading to necrosis are less well understood. Moreover, changes in necrosis as a function of age have not been studied in human lymphocytes. H 2O 2-induced death of peripheral lymphocytes (56 ...
    • Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and ... 
      Lagos, Carolina; Carvajal, Patricia; Castro, Isabel; Jara, Daniela; González, Sergio; Aguilera, Sergio; Barrera, María José; Quest, Andrew F. G.; Bahamondes, Verónica; Molina, Claudio; Urzúa, Ulises; Hermoso Ramello, Marcela; Leyton, Cecilia; González Burgos, María Julieta (Academic Press Inc., 2018)
      © 2018 Elsevier Inc.Here, we determined the 5-hydroxymethylcytosine (5hmC), 5-methylcytosine (5mC), Ten Eleven Translocation (TETs), and DNA methyltransferases (DNMTs) levels in epithelial and inflammatory cells of labial ...
    • Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite ... 
      Maldonado, H.; Calderon, C.; Burgos Bravo, Francesca; Kobler, Oliver; Zuschratter, W.; Ramirez, O.; Härtel, S.; Schneider, P.; Quest, Andrew F. G.; Herrera-Molina, R.; Leyton, L. (Elsevier B.V., 2017)
      © 2016 Elsevier B.V. Two key proteins for cellular communication between astrocytes and neurons are αvβ3 integrin and the receptor Thy-1. Binding of these molecules in the same (cis) or on adjacent (trans) cellular membranes ...
    • Astrocytic α vβ 3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by ... 
      Herrera Molina, Rodrigo; Frischknecht, Renato; Maldonado, Horacio; Seidenbecher, Constanze I.; Gundelfinger, Eckart D.; Hetz Flores, Claudio; Aylwin Ostale, María de la Luz; Schneider, Pascal; Quest, Andrew F. G.; Leyton Campos, Lisette (2012)
      Thy-1 is a membrane glycoprotein suggested to stabilize or inhibit growth of neuronal processes. However, its precise function has remained obscure, because its endogenous ligand is unknown. We previously showed that Thy-1 ...
    • ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation 
      Henríquez, Mauricio; Herrera Molina, Rodrigo; Valdivia, Alejandra; Alvarez, Alvaro; Kong, Milene; Muñoz, Nicolás; Eisner, Verónica; Jaimovich Pérez, Enrique; Schneider, Pascal; Quest, Andrew F. G.; Leyton Campos, Lisette (2011)
      Thy-1, an abundant mammalian glycoprotein, interacts with avβ3 integrin and syndecan-4 in astrocytes and thus triggers signaling events that involve RhoA and its effector p160ROCK, thereby increasing astrocyte adhesion to ...
    • Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state? 
      Peña Oyarzún, Daniel; Bravo Sagua, Roberto; Díaz Vega, Alexis; Aleman, Larissa; Chiong Lay, Mario; García Nannig, Lorena; Bambs, Claudia; Troncoso, Rodrigo; Cifuentes, Mariana; Morselli, Eugenia; Ferreccio, Catterina; Quest, Andrew F. G.; Criollo Céspedes, Alfredo; Lavandero González, Sergio (Elsevier Inc., 2018)
      © 2018 Elsevier Inc. Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; ...
    • Casein kinase 2 (CK2) increases survivin expression via enhanced β-catenin-T cell factor/lymphoid enhancer ... 
      Tapia,; Torres,; Rodriguez,; Leyton,; Quest, Andrew F. G. (2006)
      Increased expression of casein kinase 2 (CK2) is associated with hyperproliferation and suppression of apoptosis in cancer. Mutations in the tumor suppressor APC (adenomatous polyposis coli) are frequent in colon cancer ...
    • Caveolae and caveolae-like membrane domains in cellular signaling and disease: Identification of downstream ... 
      Bender, Florent; Montoya, Margarita; Monardes, Virginia; Leyton Campos, Lisette; Quest, Andrew F. G. (Society of Biology of Chile, 2002)
      Caveolae are small, flask-shaped invaginations of the plasma membrane present on a large number of mammalian cells. Recent results obtained with knock-out mice for the gene caveolin-1 demonstrate that expression of caveolin-1 ...
    • Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast ... 
      Campos, America; Salomon, Carlos; Bustos, Rocio; Díaz, Jorge; Martínez, Samuel; Silva, Veronica; Reyes, Constanza; Díaz Valdivia, Natalia; Varas Godoy, Manuel; Lobos González, Lorena; Quest, Andrew F. G. (Future Medicine Ltd., 2018)
      © 2018 2018 Future Medicine Ltd. Breast cancer is one of the most frequently diagnosed cancers and the leading cause of cancer-related deaths in women worldwide, whereby mortality is largely attributable to the development ...
    • Caveolin-1-mediated post-traditional regulation of inducible nitric oxide synthase in human colon carcinoma cells 
      Felley-Bosco, Emanuela; Bender, Florent; Quest, Andrew F. G. (2002)
      Reactive oxygen species are now widely recognized as important players contributing both to cell homeostasis and the development of disease. In this respect nitric oxide (NO) is no exception. The discussion here will center ...
    • Caveolin-1: An ambiguous partner in cell signalling and cancer 
      Quest, Andrew F. G.; Gutiérrez Pajares, Jorge L.; Torres, Vicente A. (2008)
      Caveolae are small plasma membrane invaginations that have been implicated in a variety of functions including transcytosis, potocytosis and cholesterol transport and signal transduction. The major protein component of ...
    • Cellular signaling 
      Leyton Campos, Lisette; Quest, Andrew F. G. (Society of Biology of Chile, 2002)
      Cellular signaling is an area of intense research that transcends all fields of experimental biology. As such, progress in this domain will continue to have an ever-increasing impact on society in general and health-related ...
    • Changes in Rab3D expression and distribution in the acini of Sjögren's syndrome patients are associated ... 
      Bahamondes, Verónica; Albornoz, Amelina; Aguilera, Sergio; Alliende, Cecilia; Molina, Claudio; Castro, Isabel; Urzúa, Ulises; Quest, Andrew F. G.; Barrera, María José; González, Sergio; Sánchez, Marianela; Härtel, Steffen; Hermoso Ramello, Marcela; Leyton, Cecilia; González, Ma (2011)
      Objective Oral and ocular dryness are frequent and serious symptoms of Sjögren's syndrome (SS) that reflect problems in secretion due to glandular dysfunction. Exocytosis, an important process in the secretory pathway, ...
    • Decreased phosphorylation of Y14caveolin-1 in endometrial tissue of polycystic ovary syndrome patients may ... 
      Ormazábal Leiva, Paulina Fernanda; Romero Osses, Carmen; Gabler Neale, Fernando; Quest, Andrew F. G.; Vega Blanco, María Margarita (2013)
      Endometrial tissue of patients with polycystic ovary syndrome (PCOS) shows an impaired expression of insulin signaling molecules. Tyrosine phosphorylation of the insulin receptor (IR) by insulin promotes glucose uptake by ...
    • Disruption of tight junction structure in salivary glands from Sjögren's syndrome patients is linked to ... 
      Ewert, Patricia; Aguilera, Sergio; Alliende, Cecilia; Kwon, Yoon Jeoung; Albornoz, Amelina; Molina, Claudio; Urzúa, Ulises; Quest, Andrew F. G.; Olea, Nancy; Pérez, Paola; Castro, Isabel; Barrera, María José; Romo, Rafael; Hermoso Ramello, Marcela; Leyton, Cecilia; González, Mar (2010)
      Objective. Disorganization of acinar cell apical microvilli and the presence of stromal collagen in the acinar lumen suggest that the labial salivary gland (LSG) barrier function is impaired in patients with Sjögren's ...
    • ER-to-mitochondria miscommunication and metabolic diseases 
      López Crisosto, Camila; Bravo Sagua, Roberto; Rodríguez Peña, Marcelo; Mera, Claudia; Castro, Pablo F.; Quest, Andrew F. G.; Rothermel, Beverly A.; Cifuentes, Mariana; Lavandero González, Sergio (Elsevier, 2015)
      © 2015 Elsevier B.V.. Eukaryotic cells contain a variety of subcellular organelles, each of which performs unique tasks. Thus follows that in order to coordinate these different intracellular functions, a highly dynamic ...
    • Erratum: Decreased phosphorylation of Y14Caveolin-1 in endometrial tissue of polycystic ovary syndrome ... 
      Ormazábal, Paulina; Romero Osses, Carmen; Gabler Neale, Fernando; Quest, Andrew F. G.; Vega Blanco, María Margarita (2013)
    • Helicobacter pylori -induced inflammation and epigenetic changes during gastric carcinogenesis 
      Valenzuela, Manuel A.; Canales, Jimena; Corvalán, Alejandro H.; Quest, Andrew F. G. (WJG Press, 2015)
      © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. The sequence of events associated with the development of gastric cancer has been described as "the gastric precancerous cascade". ...
    • Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects 
      Bravo, Denisse; Hoare, Anilei; Soto, Cristopher; Valenzuela, Manuel A.; Quest, Andrew F. G. (Baishideng Publishing Group Co., Limited, 2018)
      © The Author(s) 2018. Helicobacter pylori (H. pylori ) is present in roughly 50% of the human population worldwide and infection levels reach over 70% in developing countries. The infection has classically been associated ...