Browsing by Author "Walter, Robin Ann"

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    • Defect in ERK2 and p54JNK activation in aging mouse splenocytes 
      Li, Min; Torres, Claudio; Acuña Castillo, Claudio; Walter, Robin Ann; Gardner, Elizabeth M.; Murasko, Donna M.; Sierra, Felipe (2002)
      We have previously reported on a defect in both extracellular signal-regulated protein kinase (ERK) and c-jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) activation in splenocytes obtained from old rats. ...
    • T-kininogen can either induce or inhibit proliferation in Balb/c 3T3 fibroblasts, depending on the route ... 
      Aravena, Mauricio; Pérez, C.; Pérez, V.; Acuña Castillo, Claudio; Gómez, Christian; Leiva Salcedo, Elías; Nishimura, Sumiyo; Sabaj, B.; Walter, Robin Ann (ELSEVIER SCI IRELAND LTD, 2005-03)
      T-kininogen (T-KG) is a precursor of T-kinin, the most abundant kinin in rat serum, and also acts as a strong and specific cysteine proteinase inhibitor. Its expression is strongly induced during aging in rats, and expression ...
    • T-kininogen inhibits kinin-mediated activation of ERK in endothelial cells 
      Leiva-Salcedo, Elias; Perez, Viviana; Acuña Castillo, Claudio; Walter, Robin Ann; Sierra, Felipe (Society of Biology of Chile, 2002)
      Serum levels of T-kininogen increase dramatically as rats approach the end of their lifespan. Stable expression of the protein in Balb/c 3T3 fibroblasts leads to a dramatic inhibition of cell proliferation, as well as ...
    • T-kininogen: A biomarker of aging in fisher 344 rats with possible implications for the immune response 
      Acuña Castillo, Claudio; Leiva-Salcedo, Elias; Gómez, Christian R.; Pérez, Viviana; Li, Min; Torres, Claudio; Walter, Robin Ann; Murasko, Donna M.; Sierra, Felipe (Gerontological Society of America, 2006)
      T-kininogen (T-KG) is a reliable biomarker of aging in male Sprague-Dawley rats. Here we confirm, in a longitudinal study, a similar behavior in Fisher 344 rats of both sexes. In males, the increase in serum levels of T-KG ...