Browsing by Subject "Breast cancer"

Now showing items 1-20 of 20

    • ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA ... 
      Sagredo, Eduardo A.; Sagredo, Alfredo I.; Blanco, Alejandro; Rojas De Santiago, Pamela; Rivas, Solange; Assar Cuevas, Rodrigo; Pérez, Paola; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo (Elsevier, 2020)
      RNA editing has emerged as a novel mechanism in cancer progression. The double stranded RNA-specific adenosine deaminase (ADAR) modifies the expression of an important proportion of genes involved in cell cycle control, ...
    • ADAR1-mediated RNA-editing of 3'UTRs in breast cancer 
      Sagredo, Eduardo A.; Blanco, Alejandro; Sagredo, Alfredo I.; Pérez, Paola; Sepúlveda-Hermosilla, Gonzalo; Morales, Fernanda; Müller, Bettina; Verdugo, Ricardo; Marcelain Cubillos, Katherine; Harismendy, Olivier; Armisén, Ricardo (NLM (Medline), 2018)
      RESULTS: We characterized A to G(I) mRNA editing in 81 breast cell lines, showing increased editing at 3'UTR and exonic regions in breast cancer cells compared to immortalized non-malignant cell lines. In addition, tumors ...
    • Alcohol, tobacco and breast cancer - Collaborative reanalysis of individual data from 53 epidemiological ... 
      Hamajima, N.; Hirose, K.; Tajima, K.; Rohan, T.; Calle, E. E.; Heath, C. W.; Coates, R. J.; Liff, J. M.; Talamini, R.; Chantarakul, N.; Koetsawang, S.; Rachawat, D.; Morabia, A.; Schuman, L.; Stewart, W.; Szklo, M.; Bain, C.; Schofield, F.; Siskind, V.; Band, P.; Coldm (Nature Publishing Group, 2002)
      Alcohol and tobacco consumption are closely correlated and published results on their association with breast cancer have not always allowed adequately for confounding between these exposures. Over 80% of the relevant ...
    • Association of genetic variants at TOX3, 2q35 and 8q24 with the risk of familial and early-onset breast ... 
      Elematore, Isabel; González Hormazábal, Patricio; Reyes, José M.; Blanco Castillo, Rafael; Bravo, Teresa; Peralta Musre, Octavio; Gómez, Fernando; Waugh, Enrique; Margarit, Sonia; Ibáñez, Gladys; Romero Osses, Carmen; Pakomio, Janara; Roizen, Rigia; Di Capua, Gabriella A.; Jara Sosa, Lilian (Springer, 2014)
      Recent Genome-Wide Association Studies have identified several single nucleotide polymorphisms (SNPs) associated with breast cancer (BC) among women of Asian, European, and African-American ancestry. Nevertheless, the ...
    • Determinants of volumetric breast density in Chilean premenopausal women 
      Pereira, Ana; Garmendia Miguel, María Luisa; Uauy Dagach-Imbarack, Ricardo; Neira, Paulina; López Arana, Sandra; Malkov, Serghei; Shepherd, John (Springer New York LLC, 2017)
      © 2017, Springer Science+Business Media New York. Purpose: High mammographic breast density (BD) is a strong risk factor of breast cancer; however, little is known in women under 40 years of age. Recently, dual-energy X-ray ...
    • Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and ... 
      Alvarez, Carolina; Aravena, Andrés; Tapia, Teresa; Rozenblum, Ester; Solís, Luisa; Corvalán, Alejandro; Camus, Mauricio; Acevedo Alvarez, Manuel; Munroe, David; Maass Sepúlveda, Alejandro; Carvallo, Pilar (BioMed Central Ltd., 2016)
      © 2016 Alvarez et al.Background: Array CGH analysis of breast tumors has contributed to the identification of different genomic profiles in these tumors. Loss of DNA repair by BRCA1 functional deficiency in breast cancer ...
    • Direct incorporation of the NKT-cell activator α-galactosylceramide into a recombinant Listeria monocytogenes ... 
      Singh, M.; Quispe-Tintaya, W.; Chandra, D.; Jahangir, A.; Venkataswamy, M. M.; Ng, T. W.; Sharma-Kharkwal, S.; Carreño, L. J.; Porcelli, S. A.; Gravekamp, C. (Nature, 2014)
      Background: Immune suppression in the tumour microenvironment remains a major limitation to successful immunotherapy of cancer. In the current study, we analysed whether the natural killer T cell-activating glycolipid ...
    • Factors that infuence the incidence of breast cancer in Arica, Chile (Review) 
      Calaf, Gloria M.; Caba, Fresia; Farias, Jorge; Rothhammer Engel, Francisco (2010)
      Breast cancer is a common disease estimated to occur in 1 in 9 women over their lifetime. Epidemiological research has identified a number of risk factors for breast cancer. Racial and ethnic differences in breast cancer ...
    • Genetic variants in FGFR2 and MAP3K1 are associated with the risk of familial and early-onset breast cancer ... 
      Jara Sosa, Lilian; González Hormazábal, Patricio; Cerceño, Kerube; Di Capua, Gabriella A.; Reyes, José M.; Blanco Castillo, Rafael; Bravo, Teresa; Peralta Musre, Octavio; Gómez, Fernando; Waugh, Enrique; Margarit, Sonia; Gladys, Ibáñez; Romero Osses, Carmen; Pakomio, Janara; Roizen, Gigia (SPRINGER, 2012-12-07)
      Genome-Wide Association Studies have identified several loci associated with breast cancer (BC) in populations of different ethnic origins. One of the strongest associations was found in the FGFR2 gene, and MAP3K1 has ...
    • Genetic variation in MicroRNA-423 promotes proliferation, migration, invasion, and chemoresistance in breast ... 
      Morales Pisón, Sebastián; Jara Sosa, Lilian Elena Jonasa; Carrasco, Valentina; Gutiérrez Vera, Cristian Alfonso; Reyes, José Miguel; González Hormazábal, Sebastián Patricio; Carreño Márquez, Leandro Javier; Tapia Pineda, Julio César; Contreras Muñoz, Héctor Ruberly (MDPI, 2022)
      MicroRNA-423 (miR-423) is highly expressed in breast cancer (BC). Previously, our group showed that the SNP rs6505162:C>A located in the pre-miR-423 was significantly associated with increased familial BC risk in patients ...
    • Impact of route of administration on genotoxic oestrogens concentrations using oral vs transdermal oestradiol ... 
      Mauras, Nelly; Torres Santiago, Lournaris; Santen, Richard J.; Mericq, Verónica; Ross, Judith L.; Colón Otero, Gerardo; Damaso, Ligeia; Hossain, Jobayer; Wang, Qingqing; Mesaros, Clementina; Blair, Ian A. (John Wiley & Sons, 2019)
      Objective: The established link between oestrogen and breast cancer occurs via both oestrogen receptor (ER)-mediated and non ER-mediated mechanisms. The term genotoxic estrogens describes mutagenic metabolites, including ...
    • Molecular aspects of breast cancer resistance to drugs (Review) 
      Calaf, Gloria M.; Zepeda, Andrea B.; Castillo Peñaloza, Rodrigo; Figueroa, Carolina A.; Arias, Consuelo; Figueroa, Elías; Farías, Jorge G. (Spandidos Publ, 2015)
      Despite continuous advances in the knowledge of breast cancer pathophysiology, this type of neoplasia remains a leading cause of cancer-related death in women worldwide. Carcinogenesis takes a progressive course from ...
    • Oncoplastic breast consortium recommendations for mastectomy and whole breast reconstruction in the setting ... 
      Weber, Walter Paul; Shaw, Jane; Pusic, Andrea; Wyld, Lynda; Morrow, Monica; King, Tari; Mátrai, Zoltán; Heil, Jörg; Fitzal, Florian; Potter, Shelley; Rubio, Isabel T.; Cardoso, María-Joao; Gentilini, Oreste Davide; Galimberti, Viviana; Sacchini, Virgilio; Rutgers, Emeil J. T.; Benson, John; Allweiss, Tanir M.; Haug, Martin; Paulinelli, Regis R.; Kovacs, Tibor; Harder, Yves; Gulluoglu, Bahadir M.; González, Eduardo; Faridi, Andree; Elder, Elisabeth; Dubsky, Peter; Blohmer, Jens-Uwe; Bjelic-Radisic, Vesna; Barry, Mitchel; Hay, Susanne Dieroff; Bowles, Kimberly; French, James; Reitsamer, Roland; Koller, Rupert; Schrenk, Peter; Kauer-Dorner, Daniela; Biazus, Jorge; Brenelli, Fabricio; Letzkus Berrios, Jaime; Saccilotto, Ramon; Joukainen, Sarianna; Kauhanen, Susanna; Karhunen-Enckell, Ulla; Hoffmann, Juergen; Kneser, Ulrich; Kühn, Thorsten; Kontos, Michalis; Tampaki, Ekaterini Christina; Carmon, Moshe; Hadar, Tai; Catanuto, Giuseppe; Garcia-Etienne, Carlos A.; Koppert, Linetta; Gouveia, Pedro F.; Lagergren, Jakob; Svensjö, Tor; Maggi, Maggi; Kappost, Elisabeth A.; Schwab, Fabienne D.; Castrezana, Liliana; Steffens, Daniel; Krol, Janna; Tausch, Christoph; Günthert, Andreas; Knauer, Michael; Katapodi, Maria C.; Bucher, Susanne; Hauser, Nik; Kurzeder, Christian; Mucklow, Rosine; Tsoutsou, Pelagia G.; Sezer, Atakan; Çakmak, Güldeniz Karadeniz; Karanlik, Hasan; Fairbrother, Patricia; Romics, Laszlo; Montagna, Giacomo; Urban, Cicero; Walker, Melanie; Formenti, Silvia C.; Gruber, Guenther; Zimmermann, Frank; Zwahlen, Daniel Rudolf; Kuemmel, Sherko; El-Tamerf, Mahmoud; Peeters, Marie Jeanne Vrancken; Kaidar-Person, Orit; Gnant, Michael; Poortmans, Philip; de Boniface, Jana (Elsevier, 2022)
      Aim: Demand for nipple-and skin-sparing mastectomy (NSM/SSM) with immediate breast reconstruction (BR) has increased at the same time as indications for post-mastectomy radiation therapy (PMRT) have broadened. The aim of ...
    • Oncoplastic mammaplasty with geometric compensation: Evolution of the technique, outcomes and follow-up in ... 
      Paulinelli, Regis Resende; de Oliveira, Vilmar Marques; Bagnoli, Fabio; Letzkus Berríos, Jaime; Chade, Milca Cezar; Bragatto Picoli, Larissa; Dias Santos, Thauana; Bastos de Carvalho, Ana Paula; Jubé Ribeiro, Luiz Fernando; Freitas Junior, Ruffo (Wiley, 2020)
      Background and Objectives To report on the outcomes and evolution of an oncoplastic mammaplasty referred to as geometric compensation mammaplasty. Methods Seventy-three patients with malignant tumours were operated on ...
    • Preliminary pharmacogenomic-based predictive models of tamoxifen response in hormone-dependent chilean ... 
      Miranda, Carla; Galleguillos, Macarena; Torres, Roberto; Tardon, Karla; Cáceres Lillo, Dante; Lee, Kuen-shiou; Redal, María A.; Varela, Nelson M.; Quiñones Sepúlveda, Luis Abel (Frontiers Media, 2021)
      Tamoxifen (TAM), a selective oestrogen receptor modulator, is one of the most used treatments in oestrogen receptor-positive (ER+) early and metastatic breast cancer (BC) patients. The response to TAM has a high degree of ...
    • Socioeconomic, clinical, and molecular features of breast cancer influence overall survival of Latin American women 
      Almeida, Liz María de; Cortés, Sandra; Vilensky, Marta; Valenzuela, Olivia; Cortés Sanabria, Laura; Souza, Mirian de; Barbeito, Rafael Alonso; Abdelhay, Eliana; Artagaveytia, Nora; Daneri Navarro, Adrian; Llera, Andrea S.; Müller, Bettina; Podhajcer, Osvaldo L.; Velázquez, Carlos; Alcoba, Elsa; Alonso, Isabel; Bravo, Alicia I.; Camejo, Natalia; Carraro, Dirce Maria; Castro, Mónica; Cataldi, Sandra; Cayota, Alfonso; Cerda Villablanca, Mauricio David; Colombo Flores, Alicia Angelina; Crocamo, Susanne; Toro Arreola, Alicia del; Delgadillo Cristerna, Raúl; Delgado, Lucia; Breitenbach, Marisa Dreyer; Fernández, Elmer; Fernández, Jorge; Fernández, Wanda; Franco Topete, Ramón A; Gaete, Fancy; Gómez, Jorge; González Ramírez, Leivy P.; Guerrero, Marisol; Gutiérrez Rubio, Susan A.; Jalfin, Beatriz; López Vázquez, Alejandra; Loria, Dora; Míguez, Silvia; Morán Mendoza, Andres de J.; Morgan Villela, Gilberto; Mussetti, Carina; Nagai, Maria Aparecida; Oceguera Villanueva, Antonio; Reis, Rui M.; Retamales, Javier; Rodríguez, Robinson; Rosales, Cristina; Salas González, Efraín; Segovia, Laura; Sendoya, Juan M.; Silva García, Aída A.; Viña, Stella; Zagame, Livia; Jones, Beth; Szklo, Moysés (Frontiers Media, 2022)
      Molecular profile of breast cancer in Latin-American women was studied in five countries: Argentina, Brazil, Chile, Mexico, and Uruguay. Data about socioeconomic characteristics, risk factors, prognostic factors, and ...
    • Spatial autocorrelation of breast cancer mortality in the Metropolitan Region, Chile: an ecological study 
      Durán Napolitano, Doris; Monsalves, María José (Medwave Estudios, 2020)
      Introduction Breast cancer is the most common malignancy in women worldwide and Chile, being the leading cause of female cancer death. A wide variation in mortality has been reported, with geographic clusters of higher ...
    • Spectrum of BRCA1/2 point mutations and genomic rearrangements in high-risk breast/ovarian cancer Chilean families 
      González Hormazábal, Patricio; Gutiérrez Enriquez, Sara; Gaete, Daniel; Reyes, José M.; Peralta Musre, Octavio; Waugh, Enrique; Gómez, Fernando; Margarit, Sonia; Bravo, Teresa; Blanco Castillo, Rafael; Diez, Orland; Jara Sosa, Lilian (SPRINGER, 2011-04)
      The distribution of BRCA1/2 germline mutations in breast/ovarian cancer (BC/OC) families varies among different populations. In the Chilean population, there are only two reports of mutation analysis of BRCA1/2, and these ...
    • The transcriptomic portrait of locally advanced breast cancer and its prognostic value in a multi-country ... 
      Llera, Andrea Sabina; Abdelhay, Eliana Saul Furquim Werneck; Artagaveytia, Nora; Daneri Navarro, Adrián; Müller, Bettina; Velázquez, Carlos; Alcoba, Elsa B.; Alonso, Isabel; Da Quinta, Daniela B. Alves; Binato, Renata; Bravo, Alicia Inés; Camejo, Natalia; Carraro, Dirce María; Castro, Mónica; Castro Cervantes, Juan M.; Cataldi, Sandra; Cayota, Alfonso; Cerda Villablanca, Mauricio; Colombo Flores, Alicia; Crocamo, Sussane; Toro Arreola, Alicia del; Delgadillo Cisterna, Raúl; Delgado, Lucía; Dreyer Breitenbach, Marisa; Fejerman, Laura; Fernández, Elmer A.; Fernández, Jorge; Fernández, Wanda; Franco Topete, Ramón; Gabay, Carolina; Gaete Verdejo, Fancy; Garibay Escobar, Adriana; Gómez, Jorge; Greif, Gonzalo; Gross, Thomas G.; Guerrero, Marisol; Henderson, Marianne K.; López Muñoz, Miguel E.; López Vázquez, Alejandra; Maldonado, Silvina; Morán Mendoza, Valentina; Nagai, Maria Aparecida; Oceguera Villanueva, Antonio; Ortiz Martínez, Miguel A.; Quintero, Jael; Quintero Ramos, Antonio; Reis, Rui M.; Retamales, Javier; Rivera Claisse, Ernesto; Rocha, Darío; Rodríguez, Robinson; Rosales, Cristina; Salas González, Efraín; Sanchotena, Verónica; Segovia Gonzalez, Laura Aida; Sendoya, Juan Martín; Silva García, Aída; Trinchero, Alejandra; Valenzuela, Olivia; Vedham, Vidya; Zagame, Livia; Podhajcer, Osvaldo L. (MDPI, 2022)
      PurposesMost molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular ...
    • TRP channels interactome as a novel therapeutic target in breast cancer 
      Saldías Maulén, María Paz; Maureira Fuentes, Diego Javier; Orellana Serradell, Octavio Andrés; Silva del Canto, Ian; Lavanderos Andrade, Boris Joan; Cruz, Pablo; Torres Paredes, Camila Esperanza; Cáceres Lluch, Mónica; Cerda Arancibia, Oscar Alejandro (MDPI, 2021)
      Breast cancer is one of the most frequent cancer types worldwide and the first cause of cancer-related deaths in women. Although significant therapeutic advances have been achieved with drugs such as tamoxifen and trastuzumab, ...