Browsing by Subject "Calreticulin"

Now showing items 1-11 of 11

    • Comparative in vivo antiangiogenic effects of calreticulin from Trypanosoma cruzi and Homo sapiens sapiens 
      Toledo, Víctor; Ramírez, Galia; Valck, Carolina; López, Nandy; Ribeiro, Carolina H.; Maldonado, Ismael; Aguilar, Lorena; Lemus, David; Ferreira, Arturo (Society of Biology of Chile, 2010)
      Angiogenesis is a complex multi-step process of neovascularization arising from preexisting blood vessels whose generation is regulated by pro- and anti-angiogenic factors. Both Trypanosoma cruzi calreticulin (TcCRT) and ...
    • Does native Trypanosoma cruzi calreticulin mediate growth inhibition of a mammary tumor during infection? 
      Abello Cáceres, Paula; Pizarro Bauerle, Javier; Rosas Chuñil, Carlos Alberto; Maldonado, Ismael; Aguilar Guzmán, Lorena Andrea; González Guevara, Carlos Mauricio; Ramírez Toloza, Galia Andrea; Ferreira Parker, Jorge; Ferreira Vigouroux, Luis Arturo (2016)
      Background: For several decades now an antagonism between Trypanosoma cruzi infection and tumor development has been detected. The molecular basis of this phenomenon remained basically unknown until our proposal that T. ...
    • Exogenous Calreticulin, incorporated onto non-infective Trypanosoma cruzi epimastigotes, promotes their ... 
      Sosoniuk Roche, Eduardo Rodrigo; Vallejos, Gerardo; Aguilar Guzmán, Lorena Andrea; Pizarro Bauerle, Javier; Weinberger, Katherine; Rosas, Carlos; Valck Calderón, Carolina Eliana; Michalak, Marek; Ferreira, Arturo (Elsevier GmbH, 2017)
      © 2016 Elsevier GmbH Chagas disease is an endemic pathology in Latin America, now emerging in developed countries, caused by the intracellular protozoan Trypanosoma cruzi, whose life cycle involves three stages: amastigotes, ...
    • Exogenous calreticulin, incorporated onto non-infective Trypanosoma cruzi epimastigotes, promotes their ... 
      Sosoniuk Roche, Eduardo Rodrigo; Vallejos, G.; Aguilar Guzmán, Lorena Andrea; Pizarro Bauerle, Javier; Weinberger, K.; Rosas Chuñil, Carlos; Valck Calderón, Carolina Eliana; Michalak, Marek (2016)
      Chagas disease is an endemic pathology in Latin America, now emerging in developed countries, causedby the intracellular protozoan Trypanosoma cruzi, whose life cycle involves three stages: amastigotes,epimastigotes, and ...
    • F(ab')2 antibody fragments against Trypanosoma cruzi calreticulin inhibit its interaction with the first ... 
      Aguilar, Lorena; Ramírez, Galia; Valck, Carolina; Molina, María C.; Rojas, Álvaro; Schwaeble, Wilhelm; Ferreira, Viviana; Ferreira, Arturo (Society of Biology of Chile, 2005)
      Trypanosoma cruzi calreticulin (TcCRT), described in our laboratory, retains several important functional features from its vertebrate homologues. We have shown that recombinant TcCRT inhibits the human complement system ...
    • In vitro Treatment of a Murine Mammary Adenocarcinoma Cell Line with Recombinant Trypanosoma cruzi Calreticulin ... 
      Sosoniuk Roche, Eduardo Rodrigo; Cruz, Pamela; Maldonado, Ismael; Duaso, Leonora; Pesce Reyes, Bárbara; Michalak, Marek; Valck Calderón, Carolina Eliana; Ferreira Vigouroux, Arturo (Elsevier, 2020)
      American Trypanosomiasis, a parasitic disease produced by Trypanosoma cruzi (T. cruzi), endemic in Latin America, infects about 6 million people. During the chronic stage of the infection, approximately 30% of infected ...
    • Structures of parasite calreticulins provide insights into their flexibility and dual carbohydrate/peptide-binding ... 
      Moreau, Christophe; Cioci, Gianluca; Iannello, Marina; Laffly, Emmanuelle; Chouquet, Anne; Ferreira, Arturo; Thielens, Nicole M.; Gaboriaud, Christine (Int Union Crystallography, 2016)
      Calreticulin (CRT) is a multifaceted protein, initially discovered as an endoplasmic reticulum (ER) chaperone protein, that is essential in calcium metabolism. Various implications in cancer, early development and immunology ...
    • The nerve growth factor alters calreticulin translocation from the endoplasmic reticulum to the cell surface ... 
      Vera, Carolina Andrea; Oróstica Arévalo, María Lorena; Gabler Neale, Fernando; Ferreira, Arturo; Selman,; Vega Blanco, María Margarita; Romero Osses, Carmen (Spandidos Publications, 2017)
      Ovarian cancer is the seventh most common cancer among women worldwide, causing approximately 120,000 deaths every year. Immunotherapy, designed to boost the body's natural defenses against cancer, appears to be a promising ...
    • Trypanosoma cruzi calreticulin: A possible role in Chagas' disease autoimmunity 
      Ribeiro, Carolina Hager; López, Nandy C.; Ramírez, Galia A.; Valck, Carolina E.; Molina, María Carmen; Aguilar, Lorena; Rodríguez, Margarita; Maldonado, Ismael; Martínez, Ramón; González, Carlos; Troncoso, Rodrigo; Lavandero González, Sergio; Gingras, Alexandre R.; Schwaeble, Wilhelm (2009)
      Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas' disease, an endemic and chronic illness that affects 18 million people in Latin America. The mechanisms underlying its pathogenesis are controversial. There ...
    • Trypanosoma cruzi calreticulin: In vitro modulation of key immunogenic markers of both canine tumors and ... 
      Cruz, P.; Sosoniuk Roche, E.; Maldonado, I.; Torres Mendoza, Cristián G.; Ferreira, A. (Elsevier, 2020)
      Recombinant calreticulin from Trypanosoma cruzi (rTcCalr), the parasite responsible for Chagas' disease, binds to Canine Transmissible Venereal Tumor (CTVT) cells from primary cultures and to a canine mammary carcinoma ...
    • Trypanosoma cruzi carrying a monoallelic deletion of the calreticulin (TcCRT) gene are susceptible to ... 
      Sánchez Valdéz, Fernando J.; Pérez Brandán, Cecilia; Zago, M. Paola; Labriola, Carlos; Ferreira, Arturo; Basombrío, Miguel Ángel (2013-03)
      Trypanosoma cruzi calreticulin (TcCRT) can hijack complement C1, mannan-binding lectin and ficolins from serum thus inhibiting the classical and lectin complement pathway activation respectively. To understand the in ...