Browsing by Subject "Chronic hypoxia"

Now showing items 1-8 of 8

    • Effects of melatonin on the passive mechanical response of arteries in chronic hypoxic newborn lambs 
      Rivera, Eugenio; García Herrera, Claudio; González Candia, Alejandro; Celentano, Diego J.; Herrera Vídela, Emilio (Elsevier, 2020)
      Chronic hypoxia is a condition that increases the cardiovascular complications of newborns gestated and born at high altitude (HA), over 2500 m above sea level (masl). A particularly complex pathology is pulmonary arterial ...
    • Enhanced vasoconstriction mediated by alpha(1)-adrenergic mechanisms in small femoral arteries in newborn ... 
      Moraga, Fernando A.; Reyes Catalán, Roberto; Ebensperger Darrouy, Germán; López, Vasthi; Llanos Mansilla, Jorge Aníbal (Frontiers Media, 2021)
      The authors previously demonstrated that newborn llama (NBLL) express high levels of α1 adrenergic receptors, which provide a potent vasoconstriction response when compared with newborn sheep (NBSH) gestated at sea level. ...
    • High altitude pregnancies and vascular dysfunction: observations From Latin American studies 
      González Candia, Alejandro Antonio; Herrera Videla, Emilio Augusto (Frontiers Media, 2021)
      An estimated human population of 170 million inhabit at high-altitude (HA, above 2,500 m). The potential pathological effects of HA hypobaric hypoxia during gestation have been the focus of several researchers around the ...
    • Induction of controlled hypoxic pregnancy in large mammalian species 
      Brain, Kirsty L.; Allison, Beth J.; Niu, Youguo; Cross, Christine M.; Itani, Nozomi; Kane, Andrew D.; Herrera, Emilio A.; Giussani, Dino A. (American Physiological Society, 2015)
      © 2015 The Authors. Progress in the study of pregnancy complicated by chronic hypoxia in large mammals has been held back by the inability to measure long-term significant reductions in fetal oxygenation at values similar ...
    • Maternal chronic hypoxia increases expression of genes regulating lung liquid movement and surfactant ... 
      McGillick, Erin V.; Orgeig, Sandra; Allison, Beth J.; Brain, Kirsty L.; Niu, Youguo; Itani, Nozomi; Skeffington, Katie L.; Kane, Andrew D.; Herrera Videla, Emilio; Giussani, Dino A.; Morrison, Janna L. (Wiley, 2017)
      Chronic fetal hypoxaemia is a common pregnancy complication that may arise from maternal, placental and/or fetal factors. Respiratory outcome of the infant at birth likely depends on the duration, timing and severity of ...
    • Melatonin decreases pulmonary vascular remodeling and oxygen sensitivity in pulmonary hypertensive newborn lambs 
      Astorga, Cristian R.; González Candia, Alejandro; Figueroa, Esteban G.; Cañas, Daniel; Ebensperger Darrouy, Germán; Reyes Catalán, Víctor; Llanos Mansilla, Jorge; Herrera Videla, Emilio; Candia, Alejandro A. (Frontiers media SA, 2018)
      Background: Chronic hypoxia and oxidative stress during gestation lead to pulmonary hypertension of the neonate (PHN), a condition characterized by abnormal pulmonary arterial reactivity and remodeling. Melatonin has strong ...
    • Melatonin long-lasting beneficial effects on pulmonary vascular reactivity and redox balance in chronic ... 
      González Candia, Alejandro; Candia, Alejandro A.; Figueroa, Esteban G.; Feixes, Elisenda; González Candia, Cristopher; Aguilar, Simón A.; Ebensperger, Germán; Reyes, Roberto V.; Llanos, Aníbal J.; Herrera, Emilio A. (Wiley, 2020)
      Pulmonary arterial hypertension of the neonate (PAHN) is a pathophysiological condition characterized by maladaptive pulmonary vascular remodeling and abnormal contractile reactivity. This is a multifactorial syndrome ...
    • Study of the Effect of Treatment With Atrial Natriuretic Peptide (ANP) and Cinaciguat in Chronic Hypoxic ... 
      Navarrete, Álvaro; Chen, Zhuoming; Aranda, Pedro; Poblete, Daniel; Utrera, Andrés; García Herrera, Claudio; González Candia, Alejandro; Beñaldo, Felipe A.; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Herrera Videla, Emilio; Llanos, Aníbal J. (Frontiers Media, 2020)
      In this study, we assessed the effects of Atrial Natriuretic Peptide (ANP) and Cinaciguat, as experimental medicines to treat neonatal lambs exposed to chronic hypoxic conditions. To compare the different treatments, the ...