Browsing by Subject "Cisplatin"

Now showing items 1-5 of 5

    • Can pharmacogenetics explain efficacy and safety of cisplatin pharmacotherapy? 
      Roco, ángela; Cayún, Juan; Contreras, Stephania; Stojanova, Jana; Quiñones, Luis (Frontiers Media S.A., 2014)
      © 2014 Roco, Cayún, Contreras, Stojanova and Quiñones.Several recent pharmacogenetic studies have investigated the variability in both outcome and toxicity in cisplatin-based therapies. These studies have focused on the ...
    • Efficacy and Safety of Pembrolizumab or Pembrolizumab Plus Chemotherapy vs Chemotherapy Alone for Patients ... 
      Shitara, Kohei; Van Cutsem, Eric; Bang, Yung Jue; Fuchs, Charles; Wyrwicz, Lucjan; Lee, Keun-Wook; Kudaba, Iveta; Garrido, Marcelo; Chung, Hyun Cheol; Lee, Jeeyun; Castro, Hugo Raul; Mansoor, Wasat; Braghiroli, Maria Ignez; Karaseva, Nina; Caglevic, Christian; Villanueva Olivares, Luis; Goekkurt, Eray; Satake, Hironaga; Enzinger, Peter; Alsina, Maria; Benson, Al; Chao, Joseph; Ko, Andrew H.; Wainberg, Zev A.; Kher, Uma; Shah, Sukrut; Kang, S. Peter; Tabernero, Josep (Amer Medical Assoc, 2020)
      IMPORTANCE Safe and effective therapies for untreated, advanced gastric/gastroesophageal junction (G/GEJ) cancer remain an unmet need. OBJECTIVE To evaluate the antitumor activity of pembrolizumab, pembrolizumab plus ...
    • Inhibition of basal JNK activity by small interfering RNAs enhances cisplatin sensitivity and decreases DNA ... 
      Parra, Eduardo; Gutiérrez, Luis; Ferreira, Jorge (Spandidos Publications, 2015)
      Inhibition of basal Jun kinase (JNK) activity by small interfering RNAs (siRNAs) enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells. Although the JNK pathway has been extensively studied in ...
    • Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA 
      Parra, Eduardo; Ferreira, Jorge (2013)
      Cisplatin is one of the most effective and widely used chemotherapeutic agents against several types of human cancers. However, the underlying mechanisms of action are not fully understood. We aimed to investigate the ...
    • Potential use of n-3 PUFAs to prevent oxidative stress-derived ototoxicity caused by platinum-based chemotherapy 
      Cortés Fuentes, Ignacio A.; Burotto, Mauricio; Retamal, Mauricio A.; Frelinghuysen, Michael; Caglevic, Christian; Gormaz, Juan G. (Elsevier, 2020)
      Platinum-based compounds are widely used for the treatment of different malignancies due to their high effectiveness. Unfortunately, platinum-based treatment may lead to ototoxicity, an often-irreversible side effect without ...