Browsing by Subject "Clinical trial"

Now showing items 1-20 of 23

    • A comparison of the effects of the selective peripheral α1-blocker terazosin with the selective β1-blocker ... 
      Ligueros, M.; Unwin, R.; Wilkins, M. R.; Humphreys, J.; Coles, S. J.; Cleland, J. (Springer-Verlag, 1992)
      The effects of six weeks of treatment with the selective peripheral α1-adrenoceptor blocker terazosin, or the selective β1-adrenoceptor blocker atenolol on blood pressure, exercise performance and blood lipid profile were ...
    • A first in human trial implanting microalgae shows safety of photosynthetic therapy for the effective ... 
      Obaid Bobadilla, Miguel Luis; Camacho, Juan Pablo; Brenet, Marianne; Corrales Orovio, Rocío; Carvajal, Felipe; Martorell, Ximena; Werner, Consuelo; Simón, Valeska; Varas, Juan; Calderón Ortega, Wilfredo Luis; Guzmán, Christian Dani; Bono Merino, María Rosa; San Martín, Sebastián; Eblen Zajjur, Antonio; Egana, José Tomas (Frontiers Media, 2021)
      Insufficient oxygen supply represents a relevant issue in several fields of human physiology and medicine. It has been suggested that the implantation of photosynthetic cells can provide oxygen to tissues in the absence ...
    • Cardiac pharmacological preconditioning associated with omega 3 supplementation: Potential clinical applications 
      Castillo, Rodrigo L. (Nova Science Publishers, Inc., 2017)
      © 2017 Nova Science Publishers, Inc. Hypoxia is a pathophysiological condition associated with several responses at the cardiovascular, pulmonary and vascular levels, which may develop into chronic diseases. This is relevant ...
    • Clinical prediction algorithm (BRAIN) to determine risk of hematoma growth in acute intracerebral hemorrhage 
      Wang, Xia; Arima, Hisatomi; Al-Shahi Salman, Rustam; Woodward, Mark; Heeley, Emma; Stapf, Christian; Lavados Germain, Pablo Manuel; Robinson, Thompson; Huang, Yining; Wang, Jiguang; Delcourt, Candice; Anderson, Craig S. (Lippincott Williams and Wilkins, 2015)
      Background and Purpose—We developed and validated a simple algorithm to predict the risk of hematoma growth in acute spontaneous intracerebral hemorrhage (ICH) to better inform clinicians and researchers in their efforts ...
    • Core outcome measures for trials in people with coronavirus disease 2019: respiratory failure, multiorgan ... 
      Tong, Allison; Baumgart, Amanda; Evangelidis, Nicole; Viecelli, Andrea K.; Carter, Simón A.; Azevedo, Luciano Cesar; Cooper, Tess; Bersten, Andrew; Cervantes, Lilia; Chew, Derek P.; Crowe, Sally; Douglas, Ivor S.; Flemyng, Ella; Elliott, Julián H.; Hannan, Elyssa; Horby, Peter; Howell, Martín; Ju, Angela; Lee, Jaehee; Lorca Herrera, Eduardo Ignacio; Lynch, Deena; Manera, Karine E.; Marshall, John C.; Matus González, Andrea; McKenzie, Anne; Mehta, Sangeeta; Mer, Mervyn; Conway Morris, Andrew; Needham, Dale M.; Nseir, Saad; Povoa, Pedro; Reid, Mark; Sakr, Yasser; Shen, Ning; Smyth, Alan R.; Simpson, A. John; Snelling, Tom; Strippoli, Giovanni F. M.; Teixeira Pinto, Armando; Torres, Antoni; Turner, Tari; Webb, Steve; Williamson, Paula R.; Woc Colburn, Laila; Zhang, Junhua; Craig, Jonathan C. (Lippincott Williams & Wilkins, 2021)
      OBJECTIVES: Respiratory failure, multiple organ failure, shortness of breath, recovery, and mortality have been identified as critically important core outcomes by more than 9300 patients, health professionals, and ...
    • Core outcomes set for trials in people with coronavirus disease 2019 
      Tong, Allison; Elliott, Julián H.; Azevedo, Luciano César; Baumgart, Amanda; Bersten, Andrew; Cervantes, Lilia; Chew, Derek P.; Cho, Yeoungjee; Cooper, Tess; Crowe, Sally; Douglas, Ivor S.; Evangelidis, Nicole; Flemyng, Ella; Hannan, Elyssa; Horby, Peter; Howel, Martin; Lee, Jaehee; Liu, Emma; Lorca, Eduardo; Lynch, Deena; Marshall, John C.; Matus González, Andrea; McKenzie, Anne; Manera, Karine E.; McLeod, Charlie; Mehta, Sangeeta; Mer, Mervyn; Morris, Andrew Conway; Nseir, Saad; Povoa, Pedro; Reid, Mark; Sakr, Yasser; Shen, Ning; Smyth, Alan R.; Snelling, Tom; Strippoli, Giovanni F. M.; Teixeira Pinto, Armando; Torres, Antoni; Turner, Tari; Viecelli, Andrea K.; Webb, Steve; Williamson, Paula R.; Woc-Colburn, Laila; Zhang, Junhua; Craig, Jonathan C. (Lippincott Williams & Wilkins, 2020)
      Objectives: The outcomes reported in trials in coronavirus disease 2019 are extremely heterogeneous and of uncertain patient relevance, limiting their applicability for clinical decision-making. The aim of this workshop ...
    • Demographic and HIV-specific characteristics of participants enrolled in the INSIGHT Strategic Timing of ... 
      Sharma, S.; Babiker, A.G.; Emery, S.; Gordin, F.M.; Lundgren, J.D.; Neaton, J.N.; Bakowska, E.; Schechter, M.; Wiselka, M.J.; Wolff Reyes, Marcelo (British HIV Association, 2015)
      Objectives The risks and benefits of initiating antiretroviral treatment (ART) at high CD4 cell counts have not been reliably quantified. The Strategic Timing of AntiRetroviral Treatment (START) study is a randomized ...
    • Effects of an avocado-based mediterranean diet on serum lipids for secondary prevention after ischemic ... 
      Olivarría, Verónica V.; Campodónico, Paola; Vollrath, Valeska; Von Geldern, Paula; Velásquez, Carolina; Pavez, Patricia; Valente, Bárbara; Donoso, Pamela; Ginesta Frings, Carmen Alexandra; Cavada, Gabriel; Mazzon, Enrico; Navia, Víctor; Guzmán, Matías; Brinck, Pablo; Lavados, Pablo M. (Lippincott Williams & Wilkins, 2021)
      Background: A poor or unhealthy diet is responsible for an important fraction of ischemic stroke risk. Adherence to dietary patterns, such as the Mediterranean diet, rich in monounsaturated fatty acids mainly from olive ...
    • Implementation tells us more beyond pooled estimates: Secondary analysis of a multicountry mhealth trial ... 
      Carrillo-Larco, Rodrigo M.; Jiwani, Safia S.; Diez-Canseco, Francisco; Kanter, Rebecca; Beratarrechea, Andrea; Irazola, Vilma; Ramirez-Zea, Manuel; Rubinstein, Adolfo; Martinez, Homero; Miranda, J. Jaime (Journal of Medical Internet Research, 2018)
      ©Rodrigo M Carrillo-Larco, Safia S Jiwani, Francisco Diez-Canseco, Rebecca Kanter, Andrea Beratarrechea, Vilma Irazola, Manuel Ramirez-Zea, Adolfo Rubinstein, Homero Martinez, J Jaime Miranda, GISMAL Group. Background: The ...
    • International survey to establish prioritized outcomes for trials in people with Coronavirus disease 2019 
      Evangelidis, Nicole; Tong, Allison; Howell, Martín; Teixeira Pinto, Armando; Elliott, Julián H.; Azevedo, Luciano César; Bersten, Andrew; Cervantes, Lilia; Chew, Derek P.; Crowe, Sally; Douglas, Ivor S.; Flemyng, Ella; Horby, Peter; Lee, Jaehee; Lorca, Eduardo; Lynch, Deena; Marshall, John C.; McKenzie, Anne; Mehta, Sangeeta; Mer, Mervyn; Morris, Andrew Conway; Nseir, Saad; Povoa, Pedro; Reid, Mark; Sakr, Yasser; Shen, Ning; Smyth, Alan R.; Snelling, Tom; Strippoli, Giovanni F. M.; Torres, Antoni; Turner, Tari; Webb, Steve; Williamson, Paula R.; Woc-Colburn, Laila; Zhang, Junhua; Baumgart, Amanda; Cabrera, Sebastián; Cho, Yeoungjee; Cooper, Tess; Guha, Chandana; Liu, Emma; Matus González, Andrea; McLeod, Charlie; Natale, Patrizia; Saglimbene, Valeria; Viecelli, Andrea K.; Craig, Jonathan C. (Lippincott Williams & Wilkins, 2020)
      Objectives: There are over 4,000 trials conducted in people with coronavirus disease 2019. However, the variability of outcomes and the omission of patient-centered outcomes may diminish the impact of these trials on ...
    • Magnetic surgery: results from first prospective clinical trial in 50 patients 
      Rivas, Homero; Robles, Ignacio; Riquelme, Francisco; Vivanco, Marcelo; Jimenez, Julio; Marinkovic Gómez, Boris; Uribe Maturana, Mario (Lippincott Williams & Wilkins, 2018)
      Objective:To evaluate a new magnetic surgical system during reduced-port laparoscopic cholecystectomy in a prospective, multicenter clinical trial.Background:Laparoscopic instrumentation coupled by magnetic fields may ...
    • Mannitol and Outcome in Intracerebral Hemorrhage Propensity Score and Multivariable Intensive Blood Pressure ... 
      Wang, Xia; Arima, Hisatomi; Yang, Jie; Zhang, Shihong; Wu, Guojun; Woodward, Mark; Muñoz Venturelli, Paula; Lavados Germain, Pablo Manuel; Stapf, Christian; Robinson, Thompson; Heeley, Emma; Delcourt, Candice; Lindley, Richard I.; Parsons, Mark; Chalmers, John; Anderson, Craig S. (Lippincott Williams & Wilkins, 2015)
      Background and Purpose Mannitol is often used to reduce cerebral edema in acute intracerebral hemorrhage but without strong supporting evidence of benefit. We aimed to determine the impact of mannitol on outcome among ...
    • Mannitol and outcome in intracerebral hemorrhage: Propensity score and multivariable intensive blood pressure ... 
      Wang, Xia; Arima, Hisatomi; Yang, Jie; Zhang, Shihong; Wu, Guojun; Woodward, Mark; Muñoz Venturelli, Paula; Lavados Germain, Pablo Manuel; Stapf, Christian; Robinson, Thompson; Heeley, Emma; Delcourt, Candice; Lindley, Richard I.; Parsons, Mark; Chalmers, John; Anderson, Craig S. (Lippincott Williams and Wilkins, 2015)
      © 2015 American Heart Association, Inc. Background and Purpose.Mannitol is often used to reduce cerebral edema in acute intracerebral hemorrhage but without strong supporting evidence of benefit. We aimed to determine the ...
    • Maternal transfer of anti HPV 6 and 11 antibodies upon immunization with the 9-valent HPV vaccine 
      Guevara, Ana María; Suárez Pacheco, Eugenio; Victoria, Alejandro; Ngan, Hextan Y.S.; Hirschberg, Angélica Lindén; Fedrizzi, Edison; Bautista, Oliver; Shields, Christine; Joshi, Amita; Luxembourg, Alain (Taylor and Francis, 2019)
      Background: This exploratory analysis was conducted to characterize the level of HPV types 6/11 antibodies in peripartum maternal blood and in cord blood of infants born to women who received 9-valent HPV (9vHPV) vaccine ...
    • Potentiation of local anesthetic activity of neosaxitoxin with bupivacaine or epinephrine: Development of ... 
      Rodriguez-Navarro, Alberto J.; Lagos, Marcelo; Figueroa, Cristian; Garcia, Carlos; Recabal, Pedro; Silva, Pamela; Iglesias, Veronica; Lagos, Nestor (2009)
      Local anesthetics effectively block and relieve pain, but with a relatively short duration of action, limiting its analgesic effectiveness. Therefore, a long-acting local anesthetic would improve the management of pain, ...
    • Practice patterns for neurosurgical utilization and outcome in acute intracerebral hemorrhage: intensive ... 
      Guo, Rui; Blacker, David J.; Wang, Xia; Arima, Hisatomi; Lavados Germain, Pablo Manuel; Lindley, Richard I.; Chalmers, John; Anderson, Craig S.; Robinson, Thompson (Oxford university press, 2017)
      BACKGROUND: The prognosis in acute spontaneous intracerebral hemorrhage (ICH) is related to hematoma volume, where >30 mL is commonly used to define large ICH as a threshold for neurosurgical decompression but without clear ...
    • Prognostic Significance of Hyperglycemia in Acute Intracerebral Hemorrhage The INTERACT2 Study 
      Saxena, Anuhhav; Anderson, Craig S.; Wang, Xia; Sato, Shoichiro; Arima, Hisatomi; Chan, Edward; Muñoz Venturelli, Paula; Delcourt, Candice; Robinson, Thompson; Stapf, Christian; Lavados Germain, Pablo Manuel; Wang, Jiguang; Neal, Bruce; Chalmers, John; Heeley, Emma (LIPPINCOTT WILLIAMS & WILKINS, 2016)
      Background and Purpose- We aimed to determine associations of baseline blood glucose and diabetes mellitus with clinical outcomes in participants of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial ...
    • Prognostic Significance of Hyperglycemia in Acute Intracerebral Hemorrhage: The INTERACT2 Study 
      Saxena, Anubhav; Anderson, Craig S.; Wang, Xia; Sato, Shoichiro; Arima, Hisatomi; Chan, Edward; Munoz-Venturelli, Paula; Delcourt, Candice; Robinson, Thompson; Stapf, Christian; Lavados Germain, Pablo Manuel; Wang, Jiguang; Neal, Bruce; Chalmers, John; Heeley, Emma (Lippincott Williams and Wilkins, 2016)
      © 2016 American Heart Association, Inc. We aimed to determine associations of baseline blood glucose and diabetes mellitus with clinical outcomes in participants of the Intensive Blood Pressure Reduction in Acute Cerebral ...
    • Prophylactic heparin in acute intracerebral hemorrhage: a propensity score-matched analysis of the INTERACT2 study 
      Muñoz Venturelli, Paula; Wang, Xia; Lavados Germain, Pablo Manuel; Stapf, Christian; Robinson, Thompson; Lindley, Richard; Heeley, Emma; Delcourt, Candice; Chalmers, John; Anderson, Craig S. (SAGE, 2016)
      Background: Indication and timing of pharmacological venous thromboembolism prophylaxis in intracerebral hemorrhage patients is controversial. Aims: To determine whether use of subcutaneous heparin during the first 7 ...
    • Rapid Blood Pressure Lowering According to Recovery at Different Time Intervals after Acute Intracerebral ... 
      Wang, Xia; Arima, Hisatomi; Al-Shahi Salman, Rustam; Woodward, Mark; Heeley, Emma; Stapf, Christian; Lavados Germain, Pablo Manuel; Robinson, Thompson; Huang, Yining; Wang, Jiguang; Delcourt, Candice; Anderson, Craig S. (Karger, 2015)
      Background and Purpose: Early intensive blood pressure (BP) lowering has been shown to improve functional outcome in acute intracerebral hemorrhage (ICH), but the treatment effect is modest and without a clearly defined ...