Browsing by Subject "Familial breast cancer"

Now showing items 1-5 of 5

    • Association of PALB2 sequence variants with the risk of familial and early-onset breast cancer in a ... 
      Leyton, Yessica; González Hormazábal, Patricio; Blanco Castillo, Rafael; Bravo, Teresa; Fernández Ramires, Ricardo; Morales, Sebastián; Landeros, Natalia; Reyes, José M.; Peralta Musre, Octavio; Tapia, Julio C.; Gómez, Fernando; Waugh, Enrique; Ibáñez, Gladys; Pakomio, Janara; Grau, Gilberto; Jara Sosa, Lilian (BioMed Central, 2015)
      Background Germline mutations in PALB2 have been identified in approximately 1% of familial breast cancer (BC) in several populations. Nevertheless its contribution in the South-American population is unknown. The goal ...
    • Association of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR- 196a2, Pre-miR-423, miR-608 and ... 
      Morales, Sebastián; Gulppi, Felipe; González Hormazábal, Patricio; Fernández Ramires, Ricardo; Bravo, Teresa; Reyes, José; Poblete Gómez, Fernando Andrés; Waugh, Enrique; Jara Sosa, Lilian (BioMed Central, 2016)
      Background: MicroRNAs (miRNAs) are a novel class of endogenous, non-coding, single-stranded RNAs capable of regulating gene expression by suppressing translation or degrading mRNAs. Single nucleotide polymorphisms (SNP) ...
    • Genetic variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 are associated ... 
      Morales, Sebastián; De Mayo, Tomas; Gulppi, Felipe Andrés; González Hormazábal, Patricio; Carrasco, Valentina; Reyes, José Miguel; Gómez, Fernando; Waugh, Enrique; Jara, Lilian (MDPI AG, 2018)
      © 2018 by the authors. Licensee MDPI, Basel, Switzerland. Breast cancer (BC) is one of the most frequent tumors affecting women worldwide. microRNAs (miRNAs) single-nucleotide polymorphisms (SNPs) likely contribute to BC ...
    • Identification of a rare germline heterozygous deletion involving the polycistronic miR-17-92 cluster in ... 
      Mayo, Tomas de; Ziegler, Annemarie; Morales, Sebastián; Jara Sosa, Lilian (MDPI, 2018)
      Micro-RNAs (miRNAs) have emerged as novel gene expression regulators. Recent evidence strongly suggests a role for miRNAs in a large variety of cancer-related pathways. Different studies have shown that 18.7 to 37% of all ...
    • The BARD1 Cys557Ser variant and risk of familial breast cancer in a South-American population 
      González Hormazábal, Patricio; Reyes, Jose M.; Blanco, Rafael; Bravo, Teresa; Carrera, Ignacio; Peralta, Octavio; Gomez, Fernando; Waugh, Enrique; Margarit, Sonia; Ibañez, Gladys; Santos, José Luis; Jara, Lilian (2012)
      Since the discovery of the BRCA1 and BRCA2 genes, much work has been carried out to identify further breast cancer (BC) susceptibility genes. BARD1 (BRCA1-associated ring domain) was originally identified as a BRCA1-interacting ...