Browsing by Subject "Integrin"

Now showing items 1-4 of 4

    • An outside-in switch in integrin signaling caused by chemical and mechanical signals in reactive astrocytes 
      Pérez González, Leonardo; Rashid, Aysha; Combs, J. Dale; Schneider, Pascal; Rodríguez, Andrés; Salaita, Khalid; Leyton Campos, Lisette (Frontiers Media, 2021)
      Astrocyte reactivity is associated with poor repair capacity after injury to the brain, where chemical and physical changes occur in the damaged zone. Astrocyte surface proteins, such as integrins, are upregulated, and the ...
    • Extracellular matrix signals as drivers of mitochondrial bioenergetics and metabolic plasticity of cancer ... 
      Urra Faúndez, Félix Ariel; Fuentes Retamal, Sebastián Andrés; Palominos, Charlotte; Rodríguez Lucart, Yarcely A.; López Torres, Camila Alejandra; Araya Maturana, Ramiro Juan (Frontiers Media SA, 2021)
      The role of metabolism in tumor growth and chemoresistance has received considerable attention, however, the contribution of mitochondrial bioenergetics in migration, invasion, and metastasis is recently being understood. ...
    • Thy-1-integrin interactions in cis and trans mediate distinctive signaling 
      Ping, Hu; Leyton Campos, Lisette; Hagood, James S.; Barker, Thomas H. (Frontiers Media, 2022)
      Thy-1 is a cell surface glycosylphosphatidylinositol (GPI)-anchored glycoprotein that bears a broad mosaic of biological roles across various cell types. Thy-1 displays strong physiological and pathological implications ...
    • Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4 
      Kong, Milene; Muñoz, Nicolás; Valdivia, Alejandra; Alvarez, Alvaro; Herrera Molina, Rodrigo; Cárdenas, Areli; Schneider, Pascal; Burridge, Keith; Quest, Andrew F. G.; Leyton Campos, Lisette (2013)
      Cell adhesion to the extracellular matrix proteins occurs through interactions with integrins that bind to Arg-Gly-Asp (RGD) tripeptides, and syndecan-4, which recognizes the heparin-binding domain of other proteins. Both ...