Browsing by Subject "JAK2"

Now showing items 1-2 of 2

    • Growth hormone signaling in fibroblasts from newborn boys and prepubertal boys 
      Ocaranza Osses, Paula; Morales, Fernanda; Matamala, Álvaro; Gaete, Ximena; Román, Rossana; Lammoglia, Juan Javier; Cassorla Goluboff, Fernando (Elsevier, 2016-04)
      Background/aim: Responsiveness to GH in target cells is mediated by its receptor, which activates the Janus kinase-2 (JAK2) and STAT5 (signal transducers and activators of transcription 5) leading to the expression of IGF-1 ...
    • Impaired phosphorylation of JAK2-STAT5b signaling in fibroblasts from uremic children 
      Ugarte, Francisca; Irarrázabal, Carlos; Oh, Jun; Dettmar, Anne; Ceballos, María L.; Rojo, Angélica; Ibacache, M. José; Suazo, Cristián; Lozano, Mauricio; Delgado B., Iris; Cavada Chacón, Gabriel; Azócar Pruyas, Marta; Delucchi Bicocchi, María Angela; Cano Schuffeneger, Francisco (Springer, 2016)
      Chronic kidney disease (CKD) in children is characterized by severe growth failure. The growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis in uremic animals shows a post-receptor impaired phosphorylation of Janus ...