Browsing by Subject "Liver steatosis"

Now showing items 1-9 of 9

    • Dose-dependent study of the effects of acute lindane administration on rat liver superoxide anion production, ... 
      Junqueira, Virginia; Simizu, Kiyoko; Videla Cabrera, Luis; Silvia, Silvia B. (1986)
      The administration of single i.p. doses of lindane (20, 40, 60 and 80 mg/kg) to rats produced a progressive increase in the liver microsomal content of cytochrome P-450 and in the rate of superoxide anion generation, as ...
    • Enhancement in liver SREBP-1c/PPAR-α ratio and steatosis in obese patients: Correlations with insulin ... 
      Pettinelli, Paulina; Del Pozo, Talía; Araya, Julia; Rodrigo Salinas, Ramón; Araya, A. Verónica; Smok Sahid, Gladys; Csendes Juhasz, Attila; Gutierrez, Luis; Vargas Rojas, Jorge Antonio; Korn Bruzzone, Owen; Maluenda, Fernando; Diaz, Juan C.; Rencoret, Guillermo; Braghetto Miranda, Italo; Castillo, Jaime; Poniachik Teller, Jaime; (2009)
      Sterol receptor element-binding protein-1c (SREBP-1c) and peroxisome proliferator-activated receptor-α (PPAR-α) mRNA expression was assessed in liver as signaling mechanisms associated with steatosis in obese patients. ...
    • Iron-induced derangement in hepatic Δ-5 and Δ-6 desaturation capacity and fatty acid profile leading to ... 
      Barrera Ramírez, Cynthia; Valenzuela Báez, Rodrigo; Rincón Cervera, Miguel Ángel; Espinosa, Alejandra; López Arana, Sandra; González Mañan, Daniel; Romero Palacios, Nalda; Vargas, Romina; Videla Cabrera, Luis (Elsevier, 2020)
      The administration of iron induces liver oxidative stress and depletion of long-chain polyunsaturated fatty acids (LCPUFAs), n-6/n-3 LCPUFA ratio enhancement and fat accumulation, which may be prevented by antioxidant-rich ...
    • Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil ... 
      Barrera, Cynthia; Valenzuela, Rodrigo; Rincón, Miguel Ángel; Espinosa, Alejandra; Echeverria, Francisca; Romero, Nalda; Gonzalez-Mañan, Daniel; Videla Cabrera, Luis (Elsevier Inc., 2018)
      © 2018 Elsevier Inc. Enhanced iron levels in liver are associated with oxidative stress development and damage with increased fat accumulation. The aim of this work was to assess the hypothesis that antioxidant-rich extra ...
    • N-3 long-chain PUFA supplementation prevents high fat diet induced mouse liver steatosis and inflammation ... 
      Tapia Opazo, Gladys; Valenzuela, Rodrigo; Espinosa, Alejandra; Romanque, Pamela; Dossi, Camila; González Mañán, Daniel Alonso; Videla Cabrera, Luis; D'Espessailles Tapia, Amanda (Wiley-VCH Verlag, 2014)
      Scope: Dietary n-3 long-chain PUFAs (n-3 LCPUFAs) supplementation was studied in an HFD-induced (HFD is high-fat diet) steatosis and inflammation in relation to peroxisome proliferator-activated receptor alpha (PPAR-α) and ...
    • Reduction in the desaturation capacity of the liver in mice subjected to high fat diet: Relation to LCPUFA ... 
      Valenzuela Báez, Rodrigo; Barrera Ramírez, Cynthia; Espinosa, Alejandra; Llanos Vidal, Paola; Orellana, Paula; Videla Cabrera, Luis (Elsevier, 2015)
      alpha-Linolenic (ALA) and linoleic (LA) acids are precursors of long chain polyunsaturated fatty acids (LCPUFAs), FAs with important biochemical and physiological functions. In this process, desaturation reactions catalyzed ...
    • Reduction of high-fat diet-induced liver proinflammatory state by eicosapentaenoic acid plus hydroxytyrosol ... 
      Echeverría, F.; Valenzuela, R.; Espinosa, A.; Bustamante, A.; Álvarez, D.; González Mañan, Daniel; Ortiz, M.; Soto Alarcón, Sandra A.; Videla Cabrera, Luis (Elsevier Inc., 2019)
      © 2018 Elsevier Inc. High-fat diet (HFD)-fed mice show obesity with development of liver steatosis and a proinflammatory state without establishing an inflammatory reaction. The aim of this work was to assess the hypothesis ...
    • Suppression of high-fat diet-induced obesity-associated liver mitochondrial dysfunction by docosahexaenoic ... 
      Ortiz, Macarena; Soto Alarcón, Sandra; Orellana Manríquez, Paula; Espinosa Escalona, Alejandra; Campos, Cristian; López Arana, Sandra; Rincón Cervera, Miguel Ángel; Illesca, Paola; Valenzuela Báez, Rodrigo; Videla Cabrera, Luis (Elsevier, 2020)
      Objective: Obesity-induced by high-fat diet (HFD) is associated with liver steatosis, oxidative stress and mitochondrial dysfunction, which can be eluded by the co-administration of the lipid metabolism modulator docosahexaenoic ...
    • Targeting n-3 Polyunsaturated Fatty Acids in Non-alcoholic Fatty Liver Disease 
      Valenzuela, Rodrigo; Ortiz, Macarena; Hernández-Rodas, María Catalina; Echeverría, Francisca; Videla, Luis A. (Bentham Science, 2020)
      Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is characterized by abnormal hepatic accumulation of triacylglycerides in the absence of alcohol consumption, in association with Oxidative Stress (OS), a pro-inflammatory ...