Browsing by Subject "Long-acting pain blocker"

Now showing items 1-3 of 3

    • First evidence of neosaxitoxin as a long-acting pain blocker in bladder pain syndrome 
      Manríquez Galán, Valentín; Castro Caperan, Daniela; Guzmán Rojas, Rodrigo; Naser Nassar, Michel; Iglesias Álamos, Verónica; Lagos Wilson, Néstor (Springer, 2015)
      Introduction and hypothesis Neosaxitoxin is a phycotoxin whose molecular mechanism of action shows a reversible inhibition of voltage-gated sodium channels at the axonal level, impeding nerve impulse propagation. This ...
    • Gonyautoxins: First evidence in pain management in total knee arthroplasty 
      Hinzpeter Cohen, Jaime Rodrigo; Barrientos Mendoza, Cristian Nelson; Zamorano Cadenas, Álvaro Igor; Martínez, Álvaro; Palet Bonell, Miguel Jaime Luis; Wulf Ibáñez, Rodrigo Alfonso; Barahona Vásquez, Maximiliano Andrés; Sepúlveda, Joaquín M.; Guerra, Matías; Bustamante, Tamara; Del Campo, Miguel; Tapia, Eric; Lagos, Néstor (Pergamon-Elsevier Science Ltd., 2016)
      Improvements in pain management techniques in the last decade have had a major impact on the practice of total knee arthroplasty (TKA). Gonyautoxin are phycotoxins, whose molecular mechanism of action is a reversible block ...
    • Potentiation of local anesthetic activity of neosaxitoxin with bupivacaine or epinephrine: Development of ... 
      Rodriguez-Navarro, Alberto J.; Lagos, Marcelo; Figueroa, Cristian; Garcia, Carlos; Recabal, Pedro; Silva, Pamela; Iglesias, Veronica; Lagos, Nestor (2009)
      Local anesthetics effectively block and relieve pain, but with a relatively short duration of action, limiting its analgesic effectiveness. Therefore, a long-acting local anesthetic would improve the management of pain, ...