Browsing by Subject "Neurodegenerative disease"
Now showing items 1-4 of 4
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(Elsevier, 2016)Proteins along the secretory pathway are co-translationally translocated into the lumen of the endoplasmic reticulum (ER) as unfolded polypeptide chains. Afterwards, they are usually modified with N-linked glycans, correctly ...
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(Frontiers Media S.A., 2018)Copyright © 2018 Troncoso-Escudero, Parra, Nassif and Vidal. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other ...
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(Elsevier Science, 2016-10-15)One of the salient features of most neurodegenerative diseases is the aggregation of specific proteins in the brain. This proteostasis imbalance is proposed as a key event triggering the neurodegenerative cascade. The ...
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(2008)The unfolded protein response (UPR) is a conserved adaptive reaction that increases cell survival under endoplasmic reticulum (ER) stress conditions. X-box-binding protein-1 (XBP-1) is a key transcriptional regulator of ...