Browsing by Subject "Neuroinflammation"

Now showing items 1-19 of 19

    • Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures 
      Araujo, Fillipe M. de; Ferreir, Rafael S.; Souza, Cleide S.; Santos, Cleonice Creusa dos; Rodrigues, Tácio L. R. S.; Silva, Juliana Helena C. E.; Gasparotto, Juciano; Gelain, Daniel Pens; El-Bachá, Ramón S.; Costa, María de Fátima D.; Fonseca, José Claudio M.; Segura Aguilar, Juan; Costa, Silvia L.; Silva, Víctor Diógenes A. (Elsevier, 2018-05)
      Recent evidence shows that aminochrome induces glial activation related to neuroinflammation. This dopamine derived molecule induces formation and stabilization of alpha-synuclein oligomers, mitochondria dysfunction, ...
    • Aminochrome induces microglia and astrocyte activation 
      Santos, Cleonice C.; Araújo, Fillipe M.; Ferreira, Rafael S.; Silva, Vanessa B.; Silva, Juliana H.C.; Grangeiro, Maria S.; Soares, Érica N.; Pereira, Érica Patricia L.; Souza, Cleide S.; Costa, Silvia L.; Segura Aguilar, Juan; Silva, Victor Diogenes (Elsevier, 2017)
      Aminochrome has been suggested as a more physiological preclinical model capable of inducing five of the six mechanisms of Parkinson's Disease (PD). Until now, there is no evidence that aminochrome induces glial activation ...
    • Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study 
      Durrenberger, Pascal F.; Fernando, Francesca S.; Kashefi, Samira N.; Bonnert, Tim P.; Seilhean, Danielle; Nait-Oumesmar, Brahim; Schmitt, Andrea; Gebicke Haerter, Peter J.; Falkai, Peter; Grünblatt, Edna; Palkovits, Miklos; Arzberger, Thomas; Kretzschmar, Hans; Dexter, David T.; Reynolds, Richard (Springer, 2015)
      Neurodegenerative diseases of the central nervous system are characterized by pathogenetic cellular and molecular changes in specific areas of the brain that lead to the dysfunction and/or loss of explicit neuronal ...
    • Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar-Derived UChB Rats: Inhibition by ... 
      Quintanilla González, María Elena; Morales, Paola; Ezquer, Fernando; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Blackwell Publishing Ltd, 2018)
      © 2018 by the Research Society on Alcoholism Background: Life expectancy is greatly reduced in individuals presenting alcohol use disorders and chronic smoking. Literature studies suggest that common mechanisms may apply ...
    • Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, ... 
      Farfán, Nancy; Carril, Jaime; Redel, Martina; Zamorano, Marta; Araya, Maureen; Monzón, Estephania; Alvarado, Raúl; Contreras, Norton; Tapia Bustos, Andrea; Quintanilla González, María; Ezquer, Fernando; Valdés, José Luis; Israel Jacard, Yedy; Herrera Marschitz, Mario; Morales Retamales, Eugenia (2020)
      Perinatal Asphyxia (PA) is a leading cause of motor and neuropsychiatric disability associated with sustained oxidative stress, neuroinflammation, and cell death, affecting brain development. Based on a rat model of global ...
    • The need of a new and more physiological preclinical model for Parkinson’s disease 
      Segura Aguilar, Juan; Paris Pizarro, Irmgard; Muñoz, Patricia (Springer, 2016)
    • Neonatal mesenchymal stem cell treatment improves myelination impaired by global perinatal asphyxia in rats 
      Tapia Bustos, Andrea Constanza; Lespay Rebolledo, Carolyne; Vío Grossi, María Valentina; Pérez Lobos, Ronald; Casanova Ortiz, Emmanuel Alberto; Ezquer, Fernando; Herrera-Marschitz Muller, Mario Guillermo Gustavo; Morales Retamales, Eugenia Paola (MDPI, 2020)
      The effect of perinatal asphyxia (PA) on oligodendrocyte (OL), neuroinflammation, and cell viability was evaluated in telencephalon of rats at postnatal day (P)1, 7, and 14, a period characterized by a spur of neuronal ...
    • Neuroinflammation in the pathogenesis of Alzheimer's disease. A rational framework for the search of novel ... 
      Morales, Inelia; Guzmán Martínez, Leonardo; Cerda Troncoso, Cristóbal; Farías, Gonzalo A.; Maccioni Baraona, Ricardo (Frontiers Research Foundation, 2014)
      Alzheimer disease (AD) is the most common cause of dementia in people over 60 years old. The molecular and cellular alterations that trigger this disease are still diffuse, one of the reasons for the delay in finding an ...
    • Opposing roles of interferon-gamma on cells of the central nervous system in autoimmune neuroinflammation 
      Ottum, Payton A.; Arellano, Gabriel; Reyes, Lilian I.; Iruretagoyena, Mirentxu; Naves, Rodrigo (Frontiers Media, 2015)
      Multiple sclerosis (MS) is the principal cause of autoimmune neuroinflammation in humans, and its animal model, experimental autoimmune encephalomyelitis (EAE), is widely used to gain insight about their immunopathological ...
    • Outside in: Unraveling the role of neuroinflammation in the progression of Parkinson's disease 
      Troncoso-Escudero, Paulina; Parra, Alejandra; Nassif, Melissa; Vidal, Rene L. (Frontiers Media S.A., 2018)
      Copyright © 2018 Troncoso-Escudero, Parra, Nassif and Vidal. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other ...
    • Oxidative stress and neuroinflammation as a pivot in drug abuse. A focus on the therapeutic potential of ... 
      Berrios Cárcamo, Pablo; Quezada, Mauricio; Quintanilla González, María Elena; Morales, Paola; Ezquer, Marcelo; Herrera Marschitz, Mario; Israel Jacard, Yedy; Ezquer, Fernando (MDPI, 2020)
      Drug abuse is a major global health and economic problem. However, there are no pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse. Despite exerting different mechanisms of action, ...
    • Pathway to Tau Modifications and the Origins of Alzheimer's Disease 
      Maccioni Baraona, Ricardo; Tapia, José Pablo; Guzmán Martínez, Leonardo (Elsevier Inc., 2018)
    • Probiotics-based treatment as an integral approach for alcohol use disorder in alcoholic liver disease 
      Fuenzalida, Catalina; Dufeu Garfias, María Soledad; Poniachik Teller, Jaime Melchor; Roblero Cum, Juan Pablo; Valenzuela Pérez, Lucía Teresita; Beltrán Muñoz, Caroll Jenny (Frontiers Media, 2021)
      Alcoholic liver disease (ALD) is one of the leading causes of morbidity among adults with alcohol use disorder (AUD) worldwide. Its clinical course ranges from steatosis to alcoholic hepatitis, progressing to more severe ...
    • Psoriasis and mental health workshop report: exploring the links between psychosocial factors, psoriasis, ... 
      Kleyn, C. Elise; Talbot, Peter S.; Mehta, Nehal N.; Sampogna, Francesca; Bundy, Chris; Ashcroft, Darren M.; Kimball, Alexa B.; Van De Kerkhof, Peter; Griffiths, Christopher E. M.; Valenzuela Ahumada, Fernando; Van Der Walt, Joelle M.; Aberra, Tsion; Puig, Lluís (Acta Dermato-Venereologica, 2020)
      Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and/or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired ...
    • The sequenced rat brain transcriptome – its use in identifying networks predisposing alcohol consumption 
      Saba, Laura; Flink, Stephen; Vanderlinden, Lauren; Israel Jacard, Yedy; Tampier de Jong, Lutske; Colombo, Gancarlo; Kiianmaa, Kalervo; Bell, Richard; Printz, Morton; Flodman, Pamela; Koob, George; Richardson, Heather; Lombardo, Joseph; Hoffman, Paula; Tabakoff, Boris (Wiley-Blackwell, 2015)
      A quantitative genetic approach, which involves correlation of transcriptional networks with the phenotype in a recombinant inbred (RI) population and in selectively bred lines of rats, and determination of coinciding ...
    • Stage-specific role of interferon-gamma in experimental autoimmune encephalomyelitis and multiple sclerosis 
      Arellano, Gabriel; Ottum, Payton A.; Reyes, Lilian I.; Burgos, Paula; Naves, Rodrigo (Frontiers Media, 2015)
      The role of interferon (IFN)-gamma in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), has remained as an enigmatic paradox for more than 30 years. Several studies attribute ...
    • The long-lived Octodon degus as a rodent drug discovery model for Alzheimer's and other age-related diseases 
      Hurley, Michael J.; Deacon, Robert M.J.; Beyer, Katrin; Ioannou, Elena; Ibáñez, Agustin; Teeling, Jessica L.; Cogram, Patricia (Elsevier Inc., 2018)
      © 2018 Elsevier Inc. Alzheimer's disease (AD) is a multifactorial progressive neurodegenerative disease. Despite decades of research, no disease modifying therapy is available and a change of research objectives and/or ...
    • The need of a new and more physiological preclinical model for Parkinson's disease 
      Segura Aguilar, Juan; Paris Pizarro, Irmgard; Muñoz, Patricia (Birkhauser Verlag AG, 2016)
    • The Unfolded protein response in immune cells as an emerging regulator of neuroinflammation 
      Fernández Quezada, Dominique; Geisse Anguita, Antonia; Bernales Schnettler, José Ignacio; Lira, Alonso; Osorio Olivares, Fabiola (Frontiers Media, 2021)
      Immune surveillance is an essential process that safeguards the homeostasis of a healthy brain. Among the increasing diversity of immune cells present in the central nervous system (CNS), microglia have emerged as a prominent ...