Browsing by Subject "Neuromelanin"
Now showing items 1-10 of 10
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(Impact Journals LLC, 2017)
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Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures (Elsevier, 2018-05)Recent evidence shows that aminochrome induces glial activation related to neuroinflammation. This dopamine derived molecule induces formation and stabilization of alpha-synuclein oligomers, mitochondria dysfunction, ...
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(Elsevier, 2016)Astrocytes are exposed to aminochrome via the oxidation of dopamine that is taken up from the synaptic cleft after its release from dopaminergic neurons. Glutathione transferase M2-2 (GSTM2) has been shown to protect ...
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(Medknow Publications & Media Pvt, 2017)For 50 years ago was introduced L-3,4-dihydroxyphenylalanine (L-dopa) in Parkinson's disease treatment and during this significant advances has been done but what trigger the degeneration of the nigrostriatal system remain ...
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(2012)We tested the hypothesis that both VMAT-2 and DT-diaphorase are an important cellular defense against aminochrome-dependent neurotoxicity during dopamine oxidation. A cell line with VMAT-2 and DT-diaphorase over-expressed ...
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(2007)Multiple lines of evidence have implicated oxidative stress and free radical damage to the pathogenesis and etiology of Alzheimer's disease (AD). Amyloid-beta peptide contributes to oxidative damage in AD by inducing lipid ...
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(Birkhauser Verlag AG, 2016)