Browsing by Subject "UNFOLDED PROTEIN RESPONSE"

Now showing items 1-3 of 3

    • Functional Contribution of the Transcription Factor ATF4 to the Pathogenesis of Amyotrophic Lateral Sclerosis 
      Matus, Soledad; López, Estefanía; Valenzuela, Vicente; Nassif, Melissa; Hetz Flores, Claudio (PUBLIC LIBRARY SCIENCE, 2013-07-18)
      Endoplasmic reticulum (ER) stress represents an early pathological event in amyotrophic lateral sclerosis (ALS). ATF4 is a key ER stress transcription factor that plays a role in both adaptation to stress and the activation ...
    • Perturbation of endoplasmic reticulum homeostasis facilitates prion replication 
      Hetz Flores, Claudio; Castilla, Joaquín; Soto, Claudio (2007)
      Prion diseases are fatal and infectious neurodegenerative disorders characterized by the accumulation of an abnormally folded form of the prion protein ( PrP), termed PrPSc. Prion replication triggers endoplasmic reticulum ...
    • Regulation of Memory Formation by the Transcription Factor XBP1 
      Martínez, Gabriela; Vidal, Rene; Mardones, Pablo; Serrano, Felipe; Ardiles, Alvaro; Wirth, Craig; Valdés, Pamela; Thielen, Peter; Schneider, Bernard; Kerr, Bredford; Valdés Guerrero, José; Palacios, Adrián; Inestrosa, Nibaldo; Glimcher, Laurie; Hetz Flores, Claudio (CELL PRESS, 2016)
      Contextual memory formation relies on the induction of new genes in the hippocampus. A polymorphism in the promoter of the transcription factor XBP1 was identified as a risk factor for Alzheimer's disease and bipolar ...