Browsing by Subject "UPR"

Now showing items 1-20 of 23

    • Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 1. An overview 
      Dufey, Estefanie; Sepúlveda, Denisse; Rojas Rivera, Diego; Hetz Flores, Claudio (American Physiological Society, 2014)
      © 2014 the American Physiological Society. Increased demand on the protein folding capacity of the endoplasmic reticulum (ER) engages an adaptive reaction known as the unfolded protein response (UPR). The UPR regulates ...
    • Crosstalk between RNA metabolism and cellular stress responses during Zika virus replication 
      Oyarzún Arrau, Aarón; Alonso-Palomares, Luis; Valiente Echeverría, Fernando; Osorio Olivares, Fabiola; Soto Rifo, Ricardo (MDPI, 2020)
      Zika virus (ZIKV) is a mosquito-borne virus associated with neurological disorders such as Guillain-Barré syndrome and microcephaly. In humans, ZIKV is able to replicate in cell types from di erent tissues including ...
    • Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer’s disease 
      Gerakis, Yannis; Hetz Flores, Claudio (Wiley, 2018)
      Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by synaptic dysfunction and accumulation of abnormal aggregates formed by amyloid- peptides or phosphorylated tau proteins. Accumulating ...
    • Endoplasmic Reticulum Stress and the Hallmarks of Cancer 
      Urra, Hery; Dufey, Estefanie; Avril, Tony; Chevet, Eric; Hetz Flores, Claudio (Cell Press, 2016)
      © 2016 Elsevier Inc. Tumor cells are often exposed to intrinsic and external factors that alter protein homeostasis, thus producing endoplasmic reticulum (ER) stress. To cope with this, cells evoke an adaptive mechanism ...
    • Endoplasmic reticulum stress in autoimmune diseases: Can altered protein quality control and/or unfolded ... 
      Barrera, María José; Aguilera, Sergio; Castro, Isabel; González, Sergio; Carvajal, Patricia; Molina, Claudio; Hermoso, Marcela A.; González, María Julieta (Elsevier B.V., 2018)
      © 2018 Elsevier B.V. For many years, researchers in the field of autoimmunity have focused on the role of the immune components in the etiopathogenesis of autoimmune diseases. However, some studies have demonstrated the ...
    • ER chaperones in neurodegenerative disease: Folding and beyond 
      García Huerta, Paula; Bargsted, Leslie; Rivas, Alexis; Matus, Soledad; Vidal, René L. (Elsevier, 2016)
      Proteins along the secretory pathway are co-translationally translocated into the lumen of the endoplasmic reticulum (ER) as unfolded polypeptide chains. Afterwards, they are usually modified with N-linked glycans, correctly ...
    • ER proteostasis addiction in cancer biology: Novel concepts 
      Dufey, Estefanie; Urra, Hery; Hetz Flores, Claudio (Academic Press, 2015)
      © 2015 Elsevier Ltd. Endoplasmic reticulum (ER) stress is generated by various physiological and pathological conditions that induce an accumulation of misfolded proteins in its lumen. ER stress activates the unfolded ...
    • ER stress sensing mechanism: Putting off the brake on UPR transducers 
      Rojas Rivera, Diego; Rodríguez, Diego A.; Sepúlveda, Denisse; Hetz Flores, Claudio (Impact Journals LLC, 2018)
    • Fine-tuning ER stress signal transducers to treat amyotrophic lateral sclerosis 
      Medinas Bilches, Danilo; González, José V.; Falcon, Paulina; Hetz Flores, Claudio (Frontiers Media SA, 2017)
      Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motoneurons and paralysis. The mechanisms underlying neuronal degeneration in ALS are starting to be elucidated, ...
    • Function in the development of neurodegenerative diseases 
      García González, Paulina; Cabral Miranda, Felipe; Hetz Flores, Claudio; Osorio Olivares, Fabiola (Frontiers Media S.A., 2018)
      Copyright © 2018 García-González, Cabral-Miranda, Hetz and Osorio. Emerging evidence suggests that the immune and nervous systems are in close interaction in health and disease conditions. Protein aggregation and proteostasis ...
    • Gene Therapy Strategies to Restore ER Proteostasis in Disease 
      Valenzuela, Vicente; Jackson, Kasey L.; Sardi, Sergio P.; Hetz Flores, Claudio (Cell Press, 2018)
      © 2018 The American Society of Gene and Cell Therapy Proteostasis alterations are proposed as a transversal hallmark of several pathological conditions, including metabolic disorders, mechanical injury, cardiac malfunction, ...
    • Getting intimate: lysosomes and ER rendezvous to control autophagy 
      Pihán, Philippe; Hetz Flores, Claudio (Elsevier, 2020)
      The endoplasmic reticulum (ER) is the source of lysosomal calcium. The finding that the protein TMBIM6 -a putative ER calcium channel and cell death regulator-promotes calcium transfer from the ER to lysosomes to induce ...
    • Herp depletion protects from protein aggregation by up-regulating autophagy 
      Quiroga, Clara; Gatica, Damián; Paredes, Felipe; Bravo, Roberto; Troncoso, Rodrigo; Pedrozo Cibils, Zully; Rodríguez, Andrea E.; Toro, Barbra; Chiong Lay, Mario; Vicencio Bustamante, José Manuel; Hetz Flores, Claudio; Lavandero González, Sergio (Elsevier, 2013)
      Herp is an endoplasmic reticulum (ER) stress inducible protein that participates in the ER-associated protein degradation (ERAD) pathway. However, the contribution of Herp to other protein degradation pathways like autophagy ...
    • Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases 
      González Quiroz, Matias; Urra, Hery; Limia, Celia María; Hetz Flores, Claudio (Elsevier, 2018-06)
      Cancer cells are exposed to adverse conditions within the tumor microenvironment that challenge cells to adapt and survive. Several of these homeostatic perturbations insults alter the normal function of the endoplasmic ...
    • Human cDC1s display constitutive activation of the UPRsensor IRE1 
      García González, Paulina; Fernández, Dominique; Gutiérrez Cabrera, Diane; Parra Cordero, Mauro; Osorio Olivares, Fabiola (Wiley, 2022)
      The intracellular mechanisms safeguarding DC function are of biomedical interest in several immune-related diseases. Type 1 conventional DCs (cDC1s) are prominent targets of immunotherapy typified by constitutive activation ...
    • IRE1 signaling exacerbates Alzheimer's disease pathogenesis 
      Durán Aniotz, Claudia; Cornejo, Victor Hugo; Espinoza, Sandra; Ardiles, Alvaro O.; Medinas Bilches, Danilo; Salazar, Claudia; Foley, Andrew; Gajardo, Ivana; Thielen, Peter; Iwawaki, Takao; Scheper, Wiep; Soto, Claudio; Palacios, Adrian G.; Hoozemans, Jeroen J. M.; Hetz Flores, Claudio (Springer, 2017)
      Altered proteostasis is a salient feature of Alzheimer's disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress and abnormal protein aggregation. ER stress triggers the activation of the unfolded ...
    • Pro-inflammatory cytokines enhance ERAD and ATF6 alpha pathway activity in salivary glands of Sjogren's ... 
      Barrera, María José; Aguilera, Sergio; Castro, Isabel; Cortés Araya, Juan Eliecer; Bahamondes Lorca, Verónica; Quest, Andrew F. G.; Molina, Claudio; González, Sergio; Hermoso Ramello, Marcela; Urzúa Tobar, Ulises; Leyton, Cecilia; González Burgos, María Julieta (Elsevier, 2016)
      Salivary gland (SG) acinar-cells are susceptible to endoplasmic reticulum (ER) stress related to their secretory activity and the complexity of synthesized secretory products. SGs of Sji5gren's syndrome patients (SS)-patients ...
    • Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of ... 
      Mercado, Gabriela; Castillo, Valentina; Soto, Paulina; López, Nélida; Axten, Jeffrey M.; Sardi, Sergio P.; Hoozemans, Jeroen J.M.; Hetz Flores, Claudio (Academic Press Inc., 2018)
      © 2018 Elsevier Inc. Parkinson's disease (PD) is the second most common neurodegenerative disorder, leading to the progressive decline of motor control due to the loss of dopaminergic neurons in the substantia nigra pars ...
    • The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases? 
      García Huerta, Paula; Troncoso Escudero, Paulina; Jerez, Carolina; Hetz Flores, Claudio; Vidal, René L. (Elsevier Science, 2016-10-15)
      One of the salient features of most neurodegenerative diseases is the aggregation of specific proteins in the brain. This proteostasis imbalance is proposed as a key event triggering the neurodegenerative cascade. The ...
    • The Unfolded protein response in immune cells as an emerging regulator of neuroinflammation 
      Fernández Quezada, Dominique; Geisse Anguita, Antonia; Bernales Schnettler, José Ignacio; Lira, Alonso; Osorio Olivares, Fabiola (Frontiers Media, 2021)
      Immune surveillance is an essential process that safeguards the homeostasis of a healthy brain. Among the increasing diversity of immune cells present in the central nervous system (CNS), microglia have emerged as a prominent ...