Browsing by Subject "p53"

Now showing items 1-5 of 5

    • Cancer imprints an increased PARP-1 and p53-Dependent resistance to oxidative stress on lymphocytes of ... 
      Salech Morales, Felipe; Ponce, Daniela P.; San Martín Rovirosa, Carol; Rogers Castillo, Nicole; Henríquez, Mauricio; Behrens Pellegrino, María Isabel (Frontiers Media, 2018)
      We have proposed that a common biological mechanism deregulated in opposite directions might explain the inverse epidemiological association observed between Alzheimer's disease (AD) and cancer. Accordingly, we showed that ...
    • Gonadotropin releasing hormone analogs induce apoptosis by extrinsic pathway involving p53 phosphorylation ... 
      Clementi, Marisa; Sánchez, Catherine; Benítez, Dixan A.; Contreras, Héctor R.; Huidobro, Christian; Cabezas, Juan; Acevedo, Cristian; Castellón, Enrique A. (Wiley, 2009)
      BACKGROUND. Gonadotropin-releasing-hormone (GnRH) analogs are widely used to block hypothalamic–pituitary–gonadal axis and inhibit blood androgen levels in patients with prostate cancer (PCa). In addition, GnRH analogs ...
    • Human papillomavirus infection in oral squamous cell carcinomas from Chilean patients 
      Reyes Rojas, Montserrat; Rojas Alcayaga, Gonzalo; Pennacchiotti Vidal, Gina; Carrillo, Diego; Muñoz, Juan P.; Peña, Nelson; Montes, Rodrigo; Lobos Jaimes-Freyre, Nelson; Aguayo, Francisco (Elsevier, 2015)
      Human papillomavirus (HPV) is the causal agent of cervical, anogenital and a subset of oropharyngeal carcinomas. In addition, the role of HPV in oral carcinogenesis has been suggested, although the findings are inconclusive. ...
    • PARP-1 and p53 regulate the increased susceptibility to oxidative death of lymphocytes from MCI and AD patients 
      Salech Morales, Felipe; Ponce, Daniela P.; San Martín Rovirosa, Carol; Rogers Castillo, Nicole; Chacón, Carlos; Henriquez Luna, Mauricio; Behrens Pellegrino, María Isabel (Frontiers media SA, 2017)
      Mild cognitive impairment (MCI) is a clinically detectable initial stage of cognitive deterioration with a high conversion rate to dementia. There is increasing evidence that some of the cerebral alterations present in ...
    • Senescence, apoptosis or autophagy? When a damaged cell must decide its path - A mini-review 
      Vicencio Bustamante, José Miguel; Galluzzi, Lorenzo; Tajeddine, Nicolas; Ortiz, Carla; Criollo Céspedes, Alfredo; Tasdemir, Ezgi; Morselli, Eugenia; Ben Younes, Amena; Maiuri, Maria Chiara; Lavandero González, Sergio; Kroemer, Guido (2008)
      Many features of aging result from the incapacity of cells to adapt to stress conditions. When damage accumulates irreversibly, mitotic cells from renewable tissues rely on either of two mechanisms to avoid replication. ...